The Influence of Fasting and Energy Restricting Diets on Blood Pressure in Humans: A Systematic Review and Meta-Analysis



To the best of our knowledge, no comprehensive meta-analysis has been carried out to investigate the effect of different approaches of fasting and calorie restriction on blood pressure. 


Thus, the present systematic review and meta-analysis was designed to examine the effect of fasting and energy restricting diets on blood pressure in adult subjects.


We searched PubMed/Medline, Scopus, the Cochrane Library, and Google Scholar up to June 2019. The clinical trials that examined the effects of fasting and energy restricting diets on Blood Pressure was identified using MESH and non-MESH terms.


23 studies, including a total of 1397 participants, reported SBP and DBP as an outcome measure. Overall results from the random-effects model indicated that fasting and energy restricting administration elicited significant changes in SBP (weight mean difference (WMD): − 1.88 mmHg, 95% CI − 2.50, − 1.25) and DBP (WMD − 1.32 mmHg, 95% CI − 1.81, − 0.84, p = 0.000). Subgroup analyses displayed that intervention duration ≤ 12 weeks more effectively reduced SBP (WMD: -3.26 mmHg) and DBP (WMD − 1.32 mmHg). In addition, these analyses showed that fasting regimens (WMD − 3.26 mmHg) more effectively reduced SBP than energy restricting diets (WMD − 1.09 mmHg).


The principal finding of this study was that fasting and energy restricting diets elicited, overall, significant reductions in SBP and DBP. Subsequent subgroup analyses revealed that intervention duration ≤ 12 weeks and fasting regimens more effectively reduced SBP and DBP.

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The authors sincerely thank Shahid Beheshti University of Medical Sciences for all moral and material supports. This study was supported by grants from the Student Research Committee Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran (Grant’s ID: (19388) IR.SBMU.RETECH.REC.1398.665).

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Correspondence to Parvin Mirmiran.

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Kord-Varkaneh, H., Nazary-Vannani, A., Mokhtari, Z. et al. The Influence of Fasting and Energy Restricting Diets on Blood Pressure in Humans: A Systematic Review and Meta-Analysis. High Blood Press Cardiovasc Prev 27, 271–280 (2020).

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  • Meta-analysis
  • Blood pressure
  • Fasting
  • Energy restricting