Non-Alcoholic Fatty Liver Disease is Not Associated with Vitamin D Deficiency in Essential Hypertension

  • Cristiana Catena
  • Chiara Cosma
  • Valentina Camozzi
  • Mario Plebani
  • Mario Ermani
  • Leonardo A. Sechi
  • Francesco Fallo
Original Research Article

Abstract

An independent association between non-alcoholic fatty liver disease (NAFLD), a condition characterized by insulin-resistance, and low serum 25-hydroxyvitamin D [25(OH)D] levels has been reported. 25(OH)D concentrations are directly related with insulin sensitivity, whereas low [25(OH)D] predicts development of hypertension independent of glucose homeostasis alterations. We hypothesized that hypertensive patients with NAFLD have lower 25(OH)D than those without. Forty-four essential hypertensive (EH) patients with (n = 23) or without (n = 21) NAFLD were studied. No patient had diabetes mellitus, obesity, hyperlipidemia. The two hypertensive groups were compared with 24 healthy normotensive sex-, age-, body mass index (BMI)-matched subject, as controls. The two hypertensive groups had comparable age, sex, and blood pressure. BMI, glucose, insulin, homeostasis model assessment (HOMA) index and alanine aminotransferase were higher (P < 0.001 to <0.05) and plasma adiponectin was lower (P < 0.05) in EH patients with NAFLD than in those without NAFLD. Vitamin D deficiency, as defined by 25(OH)D levels <50 nmol/L, was similarly frequent in EH patients and controls (47.7 % vs. 45.8 %, P NS). Prevalence of hypovitaminosis D was not different in EH patients with and without NAFLD (37.5 % vs. 38.8 %, P NS). In patients with EH and no additional cardiometabolic risk factors NAFLD is not associated with vitamin D deficiency.

Keywords

Essential hypertension NAFLD Vitamin D 

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Copyright information

© Springer International Publishing Switzerland 2013

Authors and Affiliations

  • Cristiana Catena
    • 1
  • Chiara Cosma
    • 2
  • Valentina Camozzi
    • 2
  • Mario Plebani
    • 2
  • Mario Ermani
    • 3
  • Leonardo A. Sechi
    • 1
  • Francesco Fallo
    • 2
  1. 1.Department of Experimental and Clinical MedicineUniversity of UdineUdineItaly
  2. 2.Department of Medicine, Clinica Medica 3University of PadovaPadovaItaly
  3. 3.Department of NeurosciencesUniversity of PadovaPadovaItaly

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