MicroRNA-21 in Skin Fibrosis: Potential for Diagnosis and Treatment


Skin fibrosis is a common pathological process characterized by fibroblast proliferation and excessive deposition of extracellular matrix. However, the pathogenesis of the disease is still not clear. Previous studies have shown that microRNA-21 may play pivotal roles in the regulation of a variety of skin fibrosis, including keloid, scleroderma, and hypertrophic scar. In this review, we outline the structure, expression, and regulation of microRNA-21 and its role in fibrotic skin diseases. In future, it may be useful as a prognostic or diagnostic marker. However, there is a significant amount of work required to increase our current understanding of the role of microRNA-21 in skin fibrosis.

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The authors thank Li He and Hui Jiang for assistance with the editing and grammar of this manuscript.

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Correspondence to Lechun Lyu.

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The authors are supported by grants from the National Natural Science Foundation of China (Grant No. 81560502), the Science and Technology Leading Talent Project of Yunnan Province (Grant No. 2017HA010), the National Natural Science Foundation of Yunnan Province (Grant No. 2016FB044, 2014FB008), the Health Science and Technology Project of Yunnan Province (Grant No. 2016NS005), the Education Department Fund of Yunnan Province (Grant No. 2014Y165, 2015Z082), and the 100 Talents Program of Kunming Medical University.

Conflict of interest

Yan Li, Juan Zhang, Yuying Lei, Lechun Lyu, Ruiling Zuo, and Ting Chen have no competing financial interests.

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Li, Y., Zhang, J., Lei, Y. et al. MicroRNA-21 in Skin Fibrosis: Potential for Diagnosis and Treatment. Mol Diagn Ther 21, 633–642 (2017). https://doi.org/10.1007/s40291-017-0294-8

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