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Oncoapoptotic Markers in Oral Cancer: Prognostics and Therapeutic Perspective

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Abstract

Oral cancer is one of the most commonly found cancers in many South-Asian underdeveloped countries, especially among men in comparison to women. When considering the mortality rate among all types of existing cancers, in India oral cancer is the primary reason for death in men. Some of the major reasons contributing to the high mortality rate are late diagnosis, lack of treatment options and high prevalence of tobacco consumption. Oral cancer is often diagnosed at a stage when cancer cells have already become aggressive and become resistant to standard therapeutic options. Progression, apoptosis, angiogenesis, metastasis and invasion behold great capability to treat and detect cancer at the molecular level. Dysregulation of apoptosis is one of the most common molecular events known to be associated with the development of oral cancer. In this review, we discuss key apoptotic markers which can be used as prognostic and/or therapeutic targets in oral cancer.

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Acknowledgements and Disclosures

The authors are thankful to the Council of Scientific and Industrial Research (CSIR), New Delhi, for the award of Emeritus Scientist to Professor P.S. Bisen. No sources of funding were used to prepare this article. The authors have no conflicts of interest that are directly relevant to the content of this article.

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Authors and Affiliations

  1. Diagnostic R&D Division, RFCL Limited, New Delhi, India

    Anubhav Jain

  2. Department of Postgraduate Studies and Research in Biological Sciences, Rani Durgawati Vishwavidyalaya, Jabalpur, India

    Saurabh Bundela

  3. Rapid Diagnostic Group of Companies, New Delhi, India

    Ram P. Tiwari

  4. School of Studies in Biotechnology, Jiwaji University, Gwalior, 474 011, India

    Prakash S. Bisen

  5. Defense Research & Development Establishment, DRDO, Ministry of Defense, Government of India, Jhansi Road, Gwalior, 474 002, India

    Prakash S. Bisen

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  1. Anubhav Jain
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  2. Saurabh Bundela
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  3. Ram P. Tiwari
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  4. Prakash S. Bisen
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Correspondence to Prakash S. Bisen.

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Jain, A., Bundela, S., Tiwari, R.P. et al. Oncoapoptotic Markers in Oral Cancer: Prognostics and Therapeutic Perspective. Mol Diagn Ther 18, 483–494 (2014). https://doi.org/10.1007/s40291-014-0104-5

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