The Effect of Chronic Exercise Training on Leptin: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
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Leptin is a hormone associated with satiety, lipid oxidation, energy expenditure, and energy homeostasis. To date, the current body of research examining the effect of chronic exercise training on leptin has yielded inconsistent results.
The purpose of this meta-analysis was to provide a quantitative estimate of the magnitude of change in leptin levels following participation in exercise interventions lasting ≥ 2 weeks.
All studies included were peer-reviewed and published in English. To be included, studies randomized human participants to an exercise training group or non-exercise comparison group for an exercise training intervention. Leptin levels were measured at baseline, during, and/or after completion of the exercise training program. Random-effects models were used to aggregate a mean effect size (ES) and 95% confidence intervals (CIs), and identify potential moderators.
Seventy-two randomized controlled trials met the inclusion criteria and resulted in 107 effects (n = 3826). The mean ES of 0.24 (95% CI 0.16–0.32, p < 0.0001) indicated a decrease in leptin following an exercise training program. A decrease in %Fat (β = − 0.07, p < 0.01) was associated with a decrease in leptin after accounting for the type of control group (β = − 0.38, p < 0.0001) used in each study.
These results suggest that engaging in chronic exercise training (≥ 2 weeks) is associated with a decrease in leptin levels for individuals regardless of age and sex. However, a greater decrease in leptin occurred with a decreased percentage of body fat.
MVF conceptualized and designed the study, coded and analyzed effects, carried out the initial analysis, drafted the initial manuscript, and approved the final manuscript as submitted. EDH coded and analyzed effects, reviewed and revised the initial manuscript, and approved the final manuscript as submitted. CLW-R coded and analyzed effects, reviewed and revised the initial manuscript, and approved the final manuscript as submitted. TDW coded and analyzed effects, reviewed and revised the initial manuscript, and approved the final manuscript as submitted. WCD coded and analyzed effects, reviewed and revised the initial manuscript, and approved the final manuscript as submitted.
Compliance with Ethical Standards
Data Availability Statement
Data used for these analyses are available in a public repository through the University of Alabama, which does not issue datasets with DOIs (non-mandated deposition). The data can be downloaded directly from http://ir.ua.edu/handle/123456789/3480 in SPSS or Microsoft Excel file format.
No sources of funding were used to assist in the preparation of this article.
Conflict of interest
Michael V. Fedewa, Elizabeth D. Hathaway, Christie L. Ward-Ritacco, Tyler D. Williams, and Ward C. Dobbs declare that they have no conflicts of interest relevant to the content of this review.
- 2.Ogden CL, Carroll MD, Fryar CD, Flegal KM. Prevalence of obesity among adults and youth: United States, 2011–2014. NCHS Data Brief. 2015;219:1–8.Google Scholar
- 22.Shalitin S, Ashkenazi-Hoffnung L, Yackobovitch-Gavan M, Nagelberg N, Karni Y, Hershkovitz E, et al. Effects of a twelve-week randomized intervention of exercise and/or diet on weight loss and weight maintenance, and other metabolic parameters in obese preadolescent children. Horm Res. 2009;72(5):287–301.PubMedCrossRefGoogle Scholar
- 23.Lambert CP, Sullivan DH, Evans WJ. Effects of testosterone replacement and/or resistance training on interleukin-6, tumor necrosis factor alpha, and leptin in elderly men ingesting megestrol acetate: a randomized controlled trial. J Gerontol A Biol Sci Med Sci. 2003;58(2):165–70.PubMedCrossRefGoogle Scholar
- 38.Kim HJ, Lee S, Kim TW, Kim HH, Jeon TY, Yoon YS, et al. Effects of exercise-induced weight loss on acylated and unacylated ghrelin in overweight children. Clin Endocrinol. 2008;68(3):416–22.Google Scholar
- 44.Hedges L, Olkin I. Statistical methods for meta-analysis. 6th ed. San Diego: Academic Press; 1985. p. 79–201.Google Scholar
- 50.Hox J. Multilevel analysis: techniques and applications. 2nd ed. New York: Taylor & Francis; 2010. p. 205–32.Google Scholar
- 54.Sterne JAC, Sutton AJ, Ioannidis JPA, Terrin N, Jones DR, Lau J, et al. Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. 2011;343:1–8.Google Scholar
- 69.Donnelly JE, Blair SN, Jakicic JM, Manore MM, Rankin JW, Smith BK. American College of Sports Medicine Position Stand. Appropriate physical activity intervention strategies for weight loss and prevention of weight regain for adults. Med Sci Sports Exerc. 2009;41(2):459–71.PubMedCrossRefGoogle Scholar
- 71.Garber CE, Blissmer B, Deschenes MR, Franklin BA, Lamonte MJ, Lee IM, et al. American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc. 2011;43(7):1334–59.PubMedCrossRefGoogle Scholar
- 72.United States Department of Health and Human Services. 2008 physical activity guidelines for Americans. Washington, DC; 2008. http://www.health.gov/PAGuidelines. Accessed 12 Dec 2017.
- 75.Hopewell S, McDonald S, Clarke MJ, Egger M. Grey literature in meta-analyses of randomized trials of health care interventions. Cochrane Database Syst Rev. 2007;(2):MR000010.Google Scholar
- 85.Almenning I, Rieber-Mohn A, Lundgren KM, Løvvik TS, Garnæs KK, Moholdt T. Effects of high intensity interval training and strength training on metabolic, cardiovascular and hormonal outcomes in women with polycystic ovary syndrome: a pilot study. PLoS One. 2015;10(9):e0138793.PubMedPubMedCentralCrossRefGoogle Scholar
- 90.Balducci S, Zanuso S, Nicolucci A, Fernando F, Cavallo S, Cardelli P, et al. Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight loss. Nutr Metab Cardiovasc Dis. 2010;20(8):608–17.PubMedCrossRefGoogle Scholar
- 95.Colakoglu S, Colakoglu M, Taneli F, Cetinoz F, Turkmen M. Cumulative effects of conjugated linoleic acid and exercise on endurance development, body composition, serum leptin and insulin levels. J Sports Med Phys Fit. 2006;46(4):570–7.Google Scholar
- 96.Daryanoosh F, Mehrabani G, Shikhani H. The effect of aerobic and resistance exercises on hormonal changes in non-athlete students at Shiraz University, Southern Iran. Iran Red Crescent Med. 2010;12(2):127–32.Google Scholar
- 99.Dong-il SEO, Wi-Young SO, Dong Jun S. Changes in insulin resistance and adipokines in obese women following a 12-week programme of combined exercise training. S Afr J Res Sport Phys Educ Recreat. 2016;38(1):139–47.Google Scholar
- 100.Eftekhari E, Zafari A, Gholami M. Physical activity, lipid profiles and leptin. J Sports Med Phys Fit. 2016;56(4):465–9.Google Scholar
- 101.Fazelifar S, Ebrahim K, Sarkisian V. Effect of exercise training and detraining on serum leptin levels in obese young boys. Med Sport. 2013;66(3):325–37.Google Scholar
- 104.García-Unciti M, Izquierdo M, Idoate F, Gorostiaga E, Grijalba A, Ortega-Delgado F, et al. Weight-loss diet alone or combined with progressive resistance training induces changes in association between the cardiometabolic risk profile and abdominal fat depots. Ann Nutr Metab. 2012;61(4):296–304.PubMedCrossRefGoogle Scholar
- 108.Karim S, Afiq A. Does regular aerobic training affect basal leptin level (difference between male and female)? Afr J Microbiol Res. 2011;5(31):5591–5.Google Scholar
- 115.Ligibel JA, Giobbie-Hurder A, Olenczuk D, Campbell N, Salinardi T, Winer EP, et al. Impact of a mixed strength and endurance exercise intervention on levels of adiponectin, high molecular weight adiponectin and leptin in breast cancer survivors. Cancer Causes Control. 2009;20(8):1523–8.PubMedCrossRefGoogle Scholar
- 123.Pil-Byung C, Shin-Hwan Y, Il-Gyu K, Gwang-Suk H, Jae-Hyun Y, Han-Joon L, et al. Effects of exercise program on appetite-regulating hormones, inflammatory mediators, lipid profiles, and body composition in healthy men. J Sports Med Phys Fit. 2011;51(4):654–63.Google Scholar
- 127.Sardar MA, Hejazi SM, Abedini R. The effects of an eight-week aerobic exercise training program on serum leptin and cardiovascular risk factors among obese men with type II diabetes. Life Sci J. 2012;9(3):2518–23.Google Scholar
- 128.Shah K, Armamento-Villareal R, Parimi N, Chode S, Sinacore DR, Hilton TN, et al. Exercise training in obese older adults prevents increase in bone turnover and attenuates decrease in hip bone mineral density induced by weight loss despite decline in bone-active hormones. J Bone Miner Res. 2011;26(12):2851–9.PubMedPubMedCentralCrossRefGoogle Scholar
- 131.Suksom D, Phanpheng Y, Soogarun S, Sapwarobol S. Step aerobic combined with resistance training improves cutaneous microvascular reactivity in overweight women. J Sports Med Phys Fit. 2015;55(12):1547–54.Google Scholar
- 135.van Gemert WA, May AM, Schuit AJ, Oosterhof BY, Peeters PH, Monninkhof EM. Effect of weight loss with or without exercise on inflammatory markers and adipokines in postmenopausal women: the SHAPE-2 trial, a randomized controlled trial. Cancer Epidemiol Biomark Prev. 2016;25(5):799–806.CrossRefGoogle Scholar