Avela J, Kyrolainen H, Komi PV. Altered reflex sensitivity after repeated and prolonged passive muscle stretching. J Appl Physiol (1985). 1999;86(4):1283–91.
Cramer JT, Housh TJ, Weir JP, et al. The acute effects of static stretching on peak torque, mean power output, electromyography, and mechanomyography. Eur J Appl Physiol. 2005;93(5–6):530–9.
Fowles JR, Sale DG, MacDougall JD. Reduced strength after passive stretch of the human plantarflexors. J Appl Physiol (1985). 2000;89(3):1179–88.
Trajano GS, Nosaka K, Blazevich AJ. Neurophysiological mechanisms underpinning stretch-induced force loss. Sports Med. 2017;47(8):1531–41.
Ryan ED, Beck TW, Herda TJ, et al. Do practical durations of stretching alter muscle strength? A dose-response study. Med Sci Sports Exerc. 2008;40(8):1529–37.
Kay AD, Blazevich AJ. Moderate-duration static stretch reduces active and passive plantar flexor moment but not Achilles tendon stiffness or active muscle length. J Appl Physiol (1985). 2009;106(4):1249–56.
Mizuno T, Matsumoto M, Umemura Y. Viscoelasticity of the muscle-tendon unit is returned more rapidly than range of motion after stretching. Scand J Med Sci Sports. 2013;23(1):23–30.
Cramer JT, Beck TW, Housh TJ, et al. Acute effects of static stretching on characteristics of the isokinetic angle–torque relationship, surface electromyography, and mechanomyography. J Sports Sci. 2007;25(6):687–98.
Nelson AG, Kokkonen J. Elevated metabolic rate during passive stretching is not a sufficient aerobic warm-up. J Sport Health Sci. 2013;2(2):109–14.
Jette M, Sidney K, Blumchen G. Metabolic equivalents (METS) in exercise testing, exercise prescription, and evaluation of functional capacity. Clin Cardiol. 1990;13(8):555–65.
Wasserman K, Van Kessel AL, Burton GG. Interaction of physiological mechanisms during exercise. J Appl Physiol. 1967;22(1):71–85.
van Duijnhoven N, Hesse E, Janssen T, et al. Impact of exercise training on oxidative stress in individuals with a spinal cord injury. Eur J Appl Physiol. 2010;109(6):1059–66.
Hopman MT, Groothuis JT, Flendrie M, et al. Increased vascular resistance in paralyzed legs after spinal cord injury is reversible by training. J Appl Physiol (1985). 2002;93(6):1966–72.
Green DJ, O’Driscoll G, Blanksby BA, et al. Control of skeletal muscle blood flow during dynamic exercise: contribution of endothelium-derived nitric oxide. Sports Med. 1996;21(2):119–46.
Yamamoto K, Kawano H, Gando Y, et al. Poor trunk flexibility is associated with arterial stiffening. Am J Physiol Heart Circ Physiol. 2009;297(4):H1314–8.
Venturelli M, Ce E, Limonta E, et al. Central and peripheral responses to static and dynamic stretch of skeletal muscle: mechano- and metaboreflex implications. J Appl Phsyiol (1985). 2017;122(1):112–20.
Williams N, Coburn J, Gillum T. Static stretching vs. dynamic warm-ups: a comparison of their effects on torque and electromyography output of the quadriceps and hamstring muscles. J Sports Med Phys Fit. 2015;55(11):1310–7.
Kruse NT, Barr MW, Gilders RM, et al. Using a practical approach for determining the most effective stretching strategy in female college division I volleyball players. J Strength Cond Res. 2013;27(11):3060–7.
McMillian DJ, Moore JH, Hatler BS, et al. Dynamic vs. static-stretching warm up: the effect on power and agility performance. J Strength Cond Res. 2006;20(3):492–9.
Kallerud H, Gleeson N. Effects of stretching on performances involving stretch-shortening cycles. Sports Med. 2013;43(8):733–50.
Behm DG, Chaouachi A. A review of the acute effects of static and dynamic stretching on performance. Eur J Appl Physiol. 2011;111(11):2633–51.
Poole DC, Copp SW, Hirai DM, et al. Dynamics of muscle microcirculatory and blood-myocyte O(2) flux during contractions. Acta Physiol (Oxf). 2011;202(3):293–310.
Poole DC, Copp SW, Ferguson SK, et al. Skeletal muscle capillary function: contemporary observations and novel hypotheses. Exp Physiol. 2013;98(12):1645–58.
Poole DC, Mathieu-Costello O. Skeletal muscle capillary geometry: adaptation to chronic hypoxia. Respir Physiol. 1989;77(1):21–9.
Mathieu-Costello O, Hoppeler H, Weibel ER. Capillary tortuosity in skeletal muscles of mammals depends on muscle contraction. J Appl Physiol (1985). 1989;66(3):1436–42.
Nakao M, Segal SS. Muscle length alters geometry of arterioles and venules in hamster retractor. The Am J Physiol. 1995;268(1 Pt 2):H336–44.
Mathieu-Costello O. Capillary tortuosity and degree of contraction or extension of skeletal muscles. Microvasc Res. 1987;33(1):98–117.
Borg TK, Caulfield JB. Morphology of connective tissue in skeletal muscle. Tissue Cell. 1980;12(1):197–207.
Poole DC, Musch TI, Kindig CA. In vivo microvascular structural and functional consequences of muscle length changes. Am J Physiol. 1997;272(5 Pt 2):H2107–14.
Kindig CA, Poole DC. Sarcomere length-induced alterations of capillary hemodynamics in rat spinotrapezius muscle: vasoactive vs passive control. Microvasc Res. 2001;61(1):64–74.
Gladwell VF, Coote JH. Heart rate at the onset of muscle contraction and during passive muscle stretch in humans: a role for mechanoreceptors. J Physiol. 2002;540(Pt 3):1095–102.
Gladwell VF, Fletcher J, Patel N, et al. The influence of small fibre muscle mechanoreceptors on the cardiac vagus in humans. J Physiol. 2005;567(Pt 2):713–21.
Cui J, Blaha C, Moradkhan R, et al. Muscle sympathetic nerve activity responses to dynamic passive muscle stretch in humans. J Physiol. 2006;576(Pt 2):625–34.
Hayes SG, Kindig AE, Kaufman MP. Comparison between the effect of static contraction and tendon stretch on the discharge of group III and IV muscle afferents. J Appl Physiol (1985). 2005;99(5):1891–6.
Adreani CM, Hill JM, Kaufman MP. Responses of group III and IV muscle afferents to dynamic exercise. J Appl Physiol (1985). 1997;82(6):1811–7.
Drew RC, Bell MP, White MJ. Modulation of spontaneous baroreflex control of heart rate and indexes of vagal tone by passive calf muscle stretch during graded metaboreflex activation in humans. J Appl Physiol (1985). 2008;104(3):716–23.
McCloskey DI, Mitchell JH. Reflex cardiovascular and respiratory responses originating in exercising muscle. J Physiol. 1972;224(1):173–86.
Mitchell JH, Kaufman MP, Iwamoto GA. The exercise pressor reflex: its cardiovascular effects, afferent mechanisms, and central pathways. Annu Rev Physiol. 1983;45:229–42.
Kruse NT, Silette CR, Scheuermann BW. Influence of passive stretch on muscle blood flow, oxygenation and central cardiovascular responses in healthy young males. Am J Physiol Heart Circ Physiol. 2016;310(9):H1210–21.
Stebbins CL, Brown B, Levin D, et al. Reflex effect of skeletal muscle mechanoreceptor stimulation on the cardiovascular system. J Appl Physiol (1985). 1988;65(4):1539–47.
Wilson LB, Wall PT, Pawelczyk JA, et al. Cardiorespiratory and phrenic nerve responses to graded muscle stretch in anesthetized cats. Respir Physiol. 1994;98(3):251–66.
Fisher JP, Bell MP, White MJ. Cardiovascular responses to human calf muscle stretch during varying levels of muscle metaboreflex activation. Exp Physiol. 2005;90(5):773–81.
Herda TJ, Costa PB, Walter AA, et al. The time course of the effects of constant-angle and constant-torque stretching on the muscle-tendon unit. Scand J Med Sci Sports. 2014;24(1):62–7.
Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation. 1996;93(5):1043–65.
Shaffer F, McCraty R, Zerr CL. A healthy heart is not a metronome: an integrative review of the heart’s anatomy and heart rate variability. Front Psychol. 2014;5:1040.
McCraty R, Shaffer F. Heart rate variability: new perspectives on physiological mechanisms, assessment of self-regulatory capacity, and health risk. Glob Adv Health Med. 2015;4(1):46–61.
Mueck-Weymann M, Janshoff G, Mueck H. Stretching increases heart rate variability in healthy athletes complaining about limited muscular flexibility. Clin Auton Res. 2004;14(1):15–8.
Farinatti PT, Brandao C, Soares PP, et al. Acute effects of stretching exercise on the heart rate variability in subjects with low flexibility levels. J Strength Cond Res. 2011;25(6):1579–85.
Wong A, Figueroa A. Eight weeks of stretching training reduces aortic wave reflection magnitude and blood pressure in obese postmenopausal women. J Hum Hypertens. 2014;28(4):246–50.
Inami T, Shimizu T, Baba R, et al. Acute changes in autonomic nerve activity during passive static stretching. Am J Sport Sci Med. 2014;2(4):166–70.
Strait JB, Lakatta EG. Aging-associated cardiovascular changes and their relationship to heart failure. Heart Fail Clin. 2012;8(1):143–64.
Dinenno FA, Jones PP, Seals DR, et al. Limb blood flow and vascular conductance are reduced with age in healthy humans. Relation to elevations in sympathetic nerve activity and declines in oxygen demand. Circulation. 1999;100(2):164–70.
Nyberg M, Hellsten Y. Reduced blood flow to contracting skeletal muscle in ageing humans: is it all an effect of sand through the hourglass? J Physiol. 2016;594(8):2297–305.
Koch DW, Newcomer SC, Proctor DN. Blood flow to exercising limbs varies with age, gender, and training status. Can J Appl Physiol. 2005;30(5):554–75.
Joyner MJ, Casey DP. Regulation of increased blood flow (hyperemia) to muscles during exercise: a hierarchy of competing physiological needs. Physiol Rev. 2015;95(2):549–601.
Hughes AD, Martinez-Perez E, Jabbar AS, et al. Quantification of topological changes in retinal vascular architecture in essential and malignant hypertension. J Hypertens. 2006;24(5):889–94.
Bearden SE, Payne GW, Chisty A, et al. Arteriolar network architecture and vasomotor function with ageing in mouse gluteus maximus muscle. J Physiol. 2004;561(Pt 2):535–45.
Wenn CM, Newman DL. Arterial tortuosity. Australas Phys Eng Sci Med. 1990;13(2):67–70.
Vollmar B, Morgenthaler M, Amon M, et al. Skin microvascular adaptations during maturation and aging of hairless mice. Am J Physiol Heart Circ Physiol. 2000;279(4):H1591–9.
Sidik WA, Mazumdar JN. A mathematical study of turbulent blood flow through an arterial bifurcation. Australas Phys Eng Sci Med. 1994;17(1):1–13.
Paszkowiak JJ, Dardik A. Arterial wall shear stress: observations from the bench to the bedside. J Vasc Endovasc Surg. 2003;37(1):47–57.
McCully KK. The influence of passive stretch on muscle oxygen saturation. Adv Exp Med Biol. 2010;662:317–22.
Otsuki A, Fujita E, Ikegawa S, et al. Muscle oxygenation and fascicle length during passive muscle stretching in ballet-trained subjects. Int J Sports Med. 2011;32(7):496–502.
Trajano GS, Nosaka K, Seitz L, et al. Intermittent stretch reduces force and central drive more than continuous stretch. Med Sci Sports Exerc. 2014;46(5):902–10.
McCully KK, Hamaoka T. Near-infrared spectroscopy: what can it tell us about oxygen saturation in skeletal muscle? Exerc Sport Sci Rev. 2000;28(3):123–7.
Hamaoka T, McCully KK, Niwayama M, et al. The use of muscle near-infrared spectroscopy in sport, health and medical sciences: recent developments. Philos Trans A Math Phys Eng Sci. 1955;2011(369):4591–604.
Otsuki A, Muraoka Y, Fujita E, et al. Gender differences in muscle blood volume reduction in the tibialis anterior muscle during passive plantarflexion. Clin Physiol Funct Imaging. 2016;36(5):421–5.
Grimston SK, Nigg BM, Hanley DA, et al. Differences in ankle joint complex range of motion as a function of age. Foot Ankle. 1993;14(4):215–22.
Kellawan JM, Johansson RE, Harrell JW, et al. Exercise vasodilation is greater in women: contributions of nitric oxide synthase and cyclooxygenase. Eur J Appl Physiol. 2015;115(8):1735–46.
Kneale BJ, Chowienczyk PJ, Brett SE, et al. Gender differences in sensitivity to adrenergic agonists of forearm resistance vasculature. J Am Coll Cardiol. 2000;36(4):1233–8.
Parker BA, Smithmyer SL, Pelberg JA, et al. Sex differences in leg vasodilation during graded knee extensor exercise in young adults. J Appl Physiol (1985). 2007;103(5):1583–91.
Hart EC, Charkoudian N, Wallin BG, et al. Sex and ageing differences in resting arterial pressure regulation: the role of the beta-adrenergic receptors. J Physiol. 2011;589(Pt 21):5285–97.
Moreau KL, Donato AJ, Tanaka H, et al. Basal leg blood flow in healthy women is related to age and hormone replacement therapy status. J Physiol. 2003;547(Pt 1):309–16.
Sejersted OM, Hargens AR, Kardel KR, et al. Intramuscular fluid pressure during isometric contraction of human skeletal muscle. J Appl Physiol Respir Environ Exerc Physiol. 1984;56(2):287–95.
Sadamoto T, Bonde-Petersen F, Suzuki Y. Skeletal muscle tension, flow, pressure, and EMG during sustained isometric contractions in humans. Eur J Appl Physiol Occup Physiol. 1983;51(3):395–408.
Kruse NT, Scheuermann BW. Effect of self-administered stretching on NIRS-measured oxygenation dynamics. Clin Physiol Funct Imaging. 2016;36(2):126–33.
Ameredes BT, Provenzano MA. Regional intramuscular pressure development and fatigue in the canine gastrocnemius muscle in situ. J Appl Physiol (1985). 1997;83(6):1867–76.
Welsh DG, Segal SS. Muscle length directs sympathetic nerve activity and vasomotor tone in resistance vessels of hamster retractor. Circ Res. 1996;79(3):551–9.
Welsh DG, Segal SS. Coactivation of resistance vessels and muscle fibers with acetylcholine release from motor nerves. Am J Physiol. 1997;273(1 Pt 2):H156–63.
Armstrong RB, Duan C, Delp MD, et al. Elevations in rat soleus muscle [Ca2+] with passive stretch. J Appl Physiol (1985). 1993;74(6):2990–7.
Purslow PP. Strain-induced reorientation of an intramuscular connective tissue network: implications for passive muscle elasticity. J Biomech. 1989;22(1):21–31.
Soltow QA, Lira VA, Betters JL, et al. Nitric oxide regulates stretch-induced proliferation in C2C12 myoblasts. J Muscle Res Cell Motil. 2010;31(3):215–25.
Tatsumi R, Hattori A, Ikeuchi Y, et al. Release of hepatocyte growth factor from mechanically stretched skeletal muscle satellite cells and role of pH and nitric oxide. Mol Biol Cell. 2002;13(8):2909–18.
Thacher T, Gambillara V, da Silva RF, et al. Reduced cyclic stretch, endothelial dysfunction, and oxidative stress: an ex vivo model. Cardiovasc Pathol. 2010;19(4):e91–8.
Tidball JG, Lavergne E, Lau KS, et al. Mechanical loading regulates NOS expression and activity in developing and adult skeletal muscle. Am J Physiol. 1998;275(1 Pt 1):C260–6.
Casey DP, Madery BD, Curry TB, et al. Nitric oxide contributes to the augmented vasodilatation during hypoxic exercise. J Physiol. 2010;588(Pt 2):373–85.
Fontana L, Kennedy BK, Longo VD, et al. Medical research: treat ageing. Nature. 2014;511(7510):405–7.
Seals DR, Edward F. Adolph distinguished lecture: the remarkable anti-aging effects of aerobic exercise on systemic arteries. J Appl Physiol (1985). 2014;117(5):425–39.
Seals DR, Kaplon RE, Gioscia-Ryan RA, et al. You’re only as old as your arteries: translational strategies for preserving vascular endothelial function with aging. Physiology. 2014;29(4):250–64.
Tinken TM, Thijssen DHJ, Hopkins N, et al. Impact of shear rate modulation on vascular function in humans. Hypertens. 2009;54(2):278–85.
Chin APMJ, van Uffelen JG, Riphagen I. The functional effects of physical exercise training in frail older people: a systematic review. Sports Med. 2008;38(9):781–93.
Theou O, Stathokostas L, Roland KP, et al. The effectiveness of exercise interventions for the management of frailty: a systematic review. J Aging Res. 2011;2011:569194
Hotta K, Behnke BJ, Ghosh P, et al. Effects of muscle stretching on skeletal muscle microcirculation in old rats. FASEB J. 2016;30(1 Supplement):946-2.
Hotta K, Behnke BJ, Christou D, et al. Abstract 12490: effects of muscle stretching on endothelium-dependent vasodilation and skeletal muscle blood flow of aged rats. Circulation. 2014;130(Suppl 2):A12490-A.
Hotta K, Kamiya K, Shimizu R, et al. Stretching exercises enhance vascular endothelial function and improve peripheral circulation in patients with acute myocardial infarction. Int Heart J. 2013;54(2):59–63.
Gannon MX, Goldman M, Simms MH, et al. Transcutaneous oxygen tension monitoring during vascular reconstruction. J Cardiovasc Surg. 1986;27(4):450–3.
Shinno H, Kurose S, Yamanaka Y, et al. Evaluation of a static stretching intervention on vascular endothelial function and arterial stiffness. Eur J Sport Sci. 2017;17(5):586–92.
Kato M, Masuda T, Ogano M, et al. Stretching exercises improve vascular endothelial dysfunction through attenuation of oxidative stress in chronic heart failure patients with an implantable cardioverter defibrillator. J Cardiopulm Rehabil Prev. 2017;37(2):130–8.
Thijssen DHJ, Black MA, Pyke KE, et al. Assessment of flow-mediated dilation in humans: a methodological and physiological guideline. Am J Physiol Heart Circ Physiol. 2011;300(1):H2–12.
Rozanski A, Qureshi E, Bauman M, et al. Peripheral arterial responses to treadmill exercise among healthy subjects and atherosclerotic patients. Circulation. 2001;103(16):2084–9.
Hsieh H-J, Liu C-A, Huang B, et al. Shear-induced endothelial mechanotransduction: the interplay between reactive oxygen species (ROS) and nitric oxide (NO) and the pathophysiological implications. J Biomed Sci. 2014;21(1):3.
Giles TD. Aspects of nitric oxide in health and disease: a focus on hypertension and cardiovascular disease. J Clin Hypertens. 2006;8(12 Suppl 4):2–16.
Hahn C, Schwartz MA. Mechanotransduction in vascular physiology and atherogenesis. Nat Rev Mol Cell Biol. 2009;10(1):53–62.
Padilla J, Simmons GH, Bender SB, et al. Vascular effects of exercise: endothelial adaptations beyond active muscle beds. Physiol. 2011;26(3):132–45.
Dalager S, Paaske WP, Kristensen IB, et al. Artery-related differences in atherosclerosis expression: implications for atherogenesis and dynamics in intima-media thickness. Stroke. 2007;38(10):2698–705.
Green DJ, Hopman MT, Padilla J, et al. Vascular adaptation to exercise in humans: role of hemodynamic stimuli. Physiol Rev. 2017;97(2):495–528.
Marti CN, Gheorghiade M, Kalogeropoulos AP, et al. Endothelial dysfunction, arterial stiffness, and heart failure. J Am Coll Cardiol. 2012;60(16):1455–69.
Kim HK, Hwang CL, Yoo JK, et al. All-extremity exercise training improves arterial stiffness in older adults. Med Sci Sports Exerc. 2017;49(7):1404–11.
Tanaka H, Dinenno FA, Monahan KD, et al. Aging, habitual exercise, and dynamic arterial compliance. Circulation. 2000;102(11):1270–5.
Ashor AW, Lara J, Siervo M, et al. Effects of exercise modalities on arterial stiffness and wave reflection: a systematic review and meta-analysis of randomized controlled trials. PLoS One. 2014;9(10):e110034.
Yokoyama H, Emoto M, Fujiwara S, et al. Short-term aerobic exercise improves arterial stiffness in type 2 diabetes. Diabetes Res Clin Pract. 2004;65(2):85–93.
Phillips SA, Mahmoud AM, Brown MD, et al. Exercise interventions and peripheral arterial function: implications for cardio-metabolic disease. Prog Cardiovasc Dis. 2015;57(5):521–34.
Cortez-Cooper MY, Anton MM, Devan AE, et al. The effects of strength training on central arterial compliance in middle-aged and older adults. Eur J Cardiovasc Prev Rehabil. 2008;15(2):149–55.
Nishiwaki M, Yonemura H, Kurobe K, et al. Four weeks of regular static stretching reduces arterial stiffness in middle-aged men. Springerplus. 2015;4:555.
Yamato Y, Hasegawa N, Sato K, et al. Acute effect of static stretching exercise on arterial stiffness in healthy young adults. Am J Phys Med Rehabil. 2016;95(10):764–70.
Yamato Y, Hasegawa N, Fujie S, et al. Acute effect of stretching one leg on regional arterial stiffness in young men. Eur J Appl Physiol. 2017;117(6):1227–32.
Nishiwaki M, Kurobe K, Kiuchi A, et al. Sex differences in flexibility-arterial stiffness relationship and its application for diagnosis of arterial stiffening: a cross-sectional observational study. PLoS One. 2014;9(11):e113646.
Jackson ZS, Dajnowiec D, Gotlieb AI, et al. Partial off-loading of longitudinal tension induces arterial tortuosity. Arterioscler Thromb Vasc Biol. 2005;25(5):957–62.
Sun Z. Aging, arterial stiffness and hypertension. Hypertension. 2015;65(2):252–6.
Van Bortel LM, Spek JJ. Influence of aging on arterial compliance. J Hum Hypertens. 1998;12(9):583–6.
Joyner MJ, Charkoudian N, Wallin BG. The sympathetic nervous system and blood pressure in humans: individualized patterns of regulation and their implications. Hypertension. 2010;56(1):10–6.
Guissard N, Duchateau J. Effect of static stretch training on neural and mechanical properties of the human plantar-flexor muscles. Muscle Nerve. 2004;29(2):248–55.
Guissard N, Duchateau J. Neural aspects of muscle stretching. Exerc Sport Sci Rev. 2006;34(4):154–8.
Matthews EL, Brian MS, Coyle DE, et al. Peripheral venous distension elicits a blood pressure raising reflex in young and middle-aged adults. Am J Physiol Regul Integr Comp Physiol. 2016;310(11):R1128–33.
Cui J, McQuillan PM, Blaha C, et al. Limb venous distension evokes sympathetic activation via stimulation of the limb afferents in humans. Am J Physiol Heart Circ Physiol. 2012;303(4):H457–63.
Heffernan KS, Edwards DG, Rossow L, et al. External mechanical compression reduces regional arterial stiffness. Eur J Appl Physiol. 2007;101(6):735–41.
Heffernan KS, Collier SR, Kelly EE, et al. Arterial stiffness and baroreflex sensitivity following bouts of aerobic and resistance exercise. Int J Sports Med. 2007;28(3):197–203.
Jackson ZS, Gotlieb AI, Langille BL. Wall tissue remodeling regulates longitudinal tension in arteries. Circ Res. 2002;90(8):918–25.
Williams AD, Ahuja KD, Almond JB, et al. Progressive resistance training might improve vascular function in older women but not in older men. J Sci Med Sport. 2013;16(1):76–81.
Wong A, Sanchez-Gonzalez M, Kalfon R, et al. The effects of stretching training on cardiac autonomic function in obese postmenopausal women. Altern Ther Health Med. 2017;23(2):20–6.