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Notes
including pulmonary fibrosis, lung infiltration, pneumonitis, and alveolitis/allergic alveolitis (including fatal cases).
prednisone or methylprednisolone 1−2 mg/kg/day
including electrocardiogram, troponin assay and echocardiogram; additional testing (guided by cardiologist) may be warranted and include cardiac MRI.
References
1. Health Canada. Product monograph updates: Hydrea (hydroxyurea). Health Product InfoWatch : 4, Apr 2020. Available from: URL: https://www.canada.ca/content/dam/hc-sc/documents/services/drugs-health-products/medeffect-canada/health-product-infowatch/april-2020/hpiw-ivps_2020-04-eng.pdf
2. Health Canada. Product monograph updates: Opdivo (nivolumab). Health Product InfoWatch : 4, Apr 2020. Available from: URL: https://www.canada.ca/content/dam/hc-sc/documents/services/drugs-health-products/medeffect-canada/health-product-infowatch/april-2020/hpiw-ivps_2020-04-eng.pdf
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Recent CPM updates for hydroxycarbamide, nivolumab. Reactions Weekly 1804, 4 (2020). https://doi.org/10.1007/s40278-020-78433-3
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DOI: https://doi.org/10.1007/s40278-020-78433-3