Author Information

An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

A retrospective study of 16 women treated between 2015 and 2018 described one woman [age not stated], who developed neutropenia following treatment with palbociclib and radiotherapy for metastatic breast cancer [route, dosage, duration of treatment to reaction onset and outcome not stated].

Author comment: "Despite this potential benefit, clinicians seldom use this combination due to fear that RT may exacerbate palbociclib toxicity, particularly hematologic." "Following RT, 5 (31.3%), 1 (6.3%), and 3 (18.8%) patients were leukopenic, neutropenic, and thrombocytopenic, respectively."