Reactions Weekly

, Volume 1761, Issue 1, pp 196–196 | Cite as


Oropharyngeal histoplasmosis: 4 case reports
Case report
Author Information

An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

A retrospective study involving 10 patients (cases presented between 1995 and 2016) described four patients [one woman and three men aged 66−81 years] residing in USA, who developed oropharyngeal histoplasmosis during immunosuppression with prednisone, methotrexate, rituximab, fludarabine, bendamustine, etanercept or infliximab [routes, dosages and duration of treatments to reactions onsets not stated].

Case 1 (Patient 4): A 79-year-old woman, who had rheumatoid arthritis, was receiving immunosuppressive therapy with prednisone and methotrexate. She presented in 2009 with throat pain for 6 months and tongue pain/odynophagia for 9 months. She was found to have developed oropharyngeal histoplasmosis localised at epiglottis and tongue (positive cultures and fungal organisms on...


  1. Pincelli T, et al. Oropharyngeal histoplasmosis: a report of 10 cases. Clinical and Experimental Dermatology 44: e181-e188, No. 5, Jul 2019. Available from: URL: - USA

Copyright information

© Springer International Publishing AG 2019

Personalised recommendations