Notes
HLA = human leukocyte antigen; DRESS = drug reaction with eosinophilia and systemic symptoms.
BioVU contains nearly 250 000 unique, research-ready DNA samples linked to de-identified patient records.
HLA genes encode proteins that present antigens (i.e. foreign peptides) to T cells to stimulate an immune response.
References
Konvinse KC, et al. HLA-A*32:01 is strongly associated with vancomycin-induced drug reaction with eosinophilia and systemic symptoms. Journal of Allergy and Clinical Immunology : [10 pages], 16 Feb 2019. Available from: URL: https://doi.org/10.1016/j.jaci.2019.01.045
Pirmohamed M. HLA and immune-mediated adverse drug reactions: another hit with vancomycin. Journal of Allergy and Clinical Immunology : [7 pages], 25 Apr 2019. Available from: URL: https://dx.doi.org/10.1016/j.jaci.2019.04.009
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Specific HLA gene identified in vancomycin-induced DRESS. Reactions Weekly 1754, 12 (2019). https://doi.org/10.1007/s40278-019-62245-2
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DOI: https://doi.org/10.1007/s40278-019-62245-2