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An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
A 24-year-old woman developed anorexia nervosa (AN) while receiving immunosuppressant drug therapy with tacrolimus [not all routes stated].
The woman had no psychiatric history including an eating disorder. She was diagnosed with kidney hypoplasia at the age of 7 years. Continuous ambulatory peritoneal dialysis was started at the age of 23 years, and 5 months later, she underwent living kidney transplantation (LKT) from her mother with standard immunosuppressive regimen for immunologically low-risk patients. She satisfactorily recovered from LKT, and was discharged on tacrolimus 5 mg/day with concomitant mycophenolate mofetil and everolimus (ongoing unspecified steroids were completely tapered off prior to discharge). At the time of discharge, her weight was 40kg with BMI of...
- Kobayashi S, et al. New-Onset Anorexia Nervosa After Living Kidney Transplantation. Psychosomatics 60: 216-220, No. 2, Mar-Apr 2019. Available from: URL: http://doi.org/10.1016/j.psym.2018.05.013 - Japan