An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
In a retrospective case series, two men aged 61 and 69 years and two adult women [ages at the time of reactions onset not stated] were described, who developed various toxicities during treatment with methylprednisolone, prednisolone, azathioprine, ciclosporin, mycophenolate mofetil, triamcinolone or infliximab [not all routes, dosages and outcomes stated; duration of treatments to reactions onset not stated].
Case 1: A 61-year-old man presented with floaters and photopsiae in the right (R) eye. Further evaluation revealed panuveitis in the right eye with multifocal choroiditis in a pattern absolutely typical of sympathetic uveitis. He was treated with a pulsed IV methylprednisolone three doses of 1g each, prednisolone 1.5 mg/kg and azathioprine, which caused a significant...