An event is serious (based on the ICH definition) when the patient outcome is:Drug interaction
* congenital anomaly
* other medically important event
In a single-center retrospective cohort study of 132 paediatric patients, 8 children (4 girls and 4 boys; aged 2−9 years) were described, who developed acute kidney injury (AKI) following concomitant administration of vancomycin and piperacillin/tazobactam. Additionally, in two of these 8 children, the AKI was also attributed to gentamicin or ciclosporin [cyclosporine A] therapy [routes not stated].
Case 1: An 8-year-old girl, who had necrotising pneumonia with persistent fever, started receiving treatment with vancomycin 60 mg/kg/day and piperacillin/tazobactam 300 mg/kg/day. She had a baseline serum creatinine (SCr) level of 0.46 mg/dL and an estimated glomerular filtration rate (eGFR) of 115 mL/min/1.73m2. Subsequently, the dose of vancomycin was...