Reactions Weekly

, Volume 1695, Issue 1, pp 94–94 | Cite as

Carbamazepine/valproic acid

Hyperammonaemic encephalopathy: 2 case reports
Case report
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An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

In a case report, a 55-year-old woman and a 75 year old man were described, of which, the woman developed hyperammonaemic encephalopathy during treatment with valproic acid and carbamazepine while the man developed hyperammonaemic encephalopathy during treatment with valproic acid [not all routes stated].

Case 1: The 55-year-old woman was diagnosed with type I Sturge-Weber syndrome (encephalotrigeminal angiomatosis, with epilepsy and atrophy of the left cerebral hemisphere) and admitted for severe bilateral pneumonia and focal motor status epilepticus, which was associated with insufficient dosing of antiepileptic drugs. Her regular treatment included carbamazepine 800 mg/day, concurrently with pregabalin, clobazam, and retigabine. In order to control epilepsy, she started...


  1. Nava-Mateos JJ, et al. Treatment of encephalopathy by means of valproic acid with carglumic acid: Two case reports and a review of the literature. [Spanish]. Revista de Neurologia 65: 409-414, No. 9, Nov 2017 [Spanish; summarised from a translation] - SpainPubMedGoogle Scholar

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