An event is serious (based on the ICH definition) when the patient outcome is:
* congenital anomaly
* other medically important event
In a case series of 118 patients, 6 patients (3 males and 3 females, age ranged 42−67 years) were described, who developed cutaneous lupus erythematosus during treatment with immune globulin (Ig).
Case 1: A 62-year-old woman received IV immune globulin 65g, every 3 weeks for possible chronic inflammatory demyelinating polyneuropathy (CIDP). After the third course of immune-globulin, she developed solitary annular erythematous plaque on her cheek, and erythematous papules on her neck and chest. The lesions were itchy in nature. A skin biopsy showed a vacuolar interface-dermatitis with perivascular lymphocytic infiltrates. Thereafter, she was treated with topical steroids and her immune-globulin therapy was replaced with other brands. Subsequently, her skin lesions completely...
- Adrichem ME, et al. Drug-induced cutaneous lupus erythematosus after immunoglobulin treatment in chronic inflammatory demyelinating polyneuropathy: a case series. Journal of the Peripheral Nervous System 22: 213-218, No. 3, 05 Sep 2017. Available from: URL: http://doi.org/10.1111/jns.12218 - Netherlands