Advertisement

Reactions Weekly

, Volume 1673, Issue 1, pp 112–112 | Cite as

Carboplatin/oxaliplatin

Hypersensitivity reaction: 15 case reports
Case report
Author Information

An event is serious (based on the ICH definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * other medically important event

In a prospective study, 15 women aged 25−74 years were described, who developed hypersensitivity reaction during treatment with carboplatin or oxaliplatin [routes and dosages not stated; durations of treatments to reaction onsets and outcomes not stated ].

A 57-year-old woman, who had a history of ovarian cancer, started receiving treatment with carboplatin. During fourteenth cycle of carboplatin, she developed grade 3 hypersensitivity reaction. Tryptase level was 39.2 µg/L. She underwent rapid desensitisation which showed positive reaction. Basophil activation test was also positive.

A 59-year-old woman, who had a history of ovarian cancer, started receiving treatment with carboplatin. During eleventh cycle of carboplatin, she developed grade 2 hypersensitivity reaction....

Reference

  1. Giavina-Bianchi P, et al. Basophil Activation Test is a Relevant Biomarker of the Outcome of Rapid Desensitization in Platinum Compounds-Allergy. Journal of Allergy and Clinical Immunology: In Practice 5: 728-736, No. 3, May-Jun 2017. Available from: URL: http://doi.org/10.1016/j.jaip.2016.11.006 - USA

Copyright information

© Springer International Publishing AG 2017

Personalised recommendations