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, Volume 1626, Issue 1, pp 97–97 | Cite as

Influenza virus vaccine

Herpes simplex virus reactivation leading to Herpes simplex encephalitis and acute retinal necrosis: case report
Case report
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An event is serious (FDA MedWatch definition) when the patient outcome is:

  • * death

  • * life-threatening

  • * hospitalisation

  • * disability

  • * congenital anomaly

  • * requires intervention to prevent permanent impairment or damage

A 47-year-old man developed Herpes simplex virus reactivation leading to Herpes simplex encephalitis and acute retinal necrosis (ARN) following immunisation with influenza virus vaccine [routes and dosages not stated].

The man, who had a history of dyslipidaemia, hypertension and insulin dependent diabetes mellitus, presented to an outside hospital in November 2012 with aphasia, acute fever and dysnomia. He also had several days history of malaise, weakness and hiccups. His laboratory evaluations demonstrated leucocytosis, hyponatraemia, hyperglycaemia and hypochloraemia. He was tachycardic and was admitted to the ICU for dehydration and sepsis. His lumbar puncture showed clear fluid with elevated RBCs, WBCs and glucose. A brain MRI highlighted oedema...

Reference

  1. Hassman LM, et al. Immunologic factors may play a role in herpes simplex virus 1 reactivation in the brain and retina after influenza vaccination. IDCases 6: 47-51, Sep 2016. Available from: URL: http://doi.org/10.1016/j.idcr.2016.09.012 - USACrossRefPubMedPubMedCentralGoogle Scholar

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© Springer International Publishing Switzerland 2016

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