This is a preview of subscription content, log in via an institution to check access.
Notes
The updated Summary of Product Characteristics for Glucophage now states that "Metformin may be used in patients with moderate renal impairment, stage 3a (creatinine clearance [CrCl] 45-59 mL/min or estimated glomerular filtration rate [eGFR] 45-59 mL/min/1.73 m 2) only in the absence of other conditions that may increase the risk of lactic acidosis" and also that "If CrCl or eGFR fall <45 mL/min or <45 mL/min/1.73 m 2 respectively, metformin must be discontinued immedia tely".
Reference
Chowdhury TA, et al. Using metformin in the presence of renal disease. BMJ 350: [2 pages], 14 Apr 2015. Available from: URL: http://dx.doi.org/10.1136/bmj.h1758
Rights and permissions
About this article
Cite this article
Metformin in patients with renal disease: restrictive guidelines?. Reactions Weekly 1548, 7 (2015). https://doi.org/10.1007/s40278-015-9830-7
Published:
Issue Date:
DOI: https://doi.org/10.1007/s40278-015-9830-7