Notes
The ICE II (Investigational Chemotherapy for Elderly patients II) trial was planned as a sequential phase II/III study. However, the phase III portion of the trial was not initiated due to slow accrual and limited financial support (despite approval for continuation by the independent Data Monitoring Committee).
Reference
von Minckwitz G, et al. A randomized phase 2 study comparing EC or CMF versus nab-paclitaxel plus capecitabine as adjuvant chemotherapy for nonfrail elderly patients with moderate to high-risk early breast cancer (ICE II-GBG 52). Cancer : [10 pages], 25 Jun 2015. Available from: URL: http://dx.doi.org/10.1002/cncr.29506
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ICE II trial results in elderly patients with breast cancer. Reactions Weekly 1560, 12 (2015). https://doi.org/10.1007/s40278-015-3384-6
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DOI: https://doi.org/10.1007/s40278-015-3384-6