PharmacoEconomics & Outcomes News

, Volume 828, Issue 1, pp 33–33 | Cite as

Two-dose measles vaccination cost effective in Zhejiang, China

Clinical study

The two-dose measles vaccination programme currently used routinely in Zhejiang Province, China, provides substantial benefits and is cost effective, according to an economic evaluation conducted by researchers from China.

The researchers used a Markov model to evaluate the cost benefit and cost effectiveness of the current measles vaccination programme, compared with no vaccination, for a hypothetical birth cohort of 578 000 children born in Zhejiang Province in 2014. The analysis was conducted from a payer perspective.

The model predicted that 220 899 measles infections would occur over 40 years in the absence of the vaccination programme, resulting in 216 early deaths. The direct costs of these infections were estimated at $US85.9 million. The total costs of the vaccination programme were estimated at approximately $2.52 million, with $10 million illness costs due to immunisation failure. The benefit-cost ratio was 6.06, meaning the programme saves $6.06 for every dollar spent on immunisation. The net present value was $73.38 million. The model also showed that 195 165 measles cases and 191 early deaths would be prevented by the vaccination programme. The incremental cost-effectiveness ratio was $12.91 per case averted and $13 213 per death averted. These values are below the accepted cost-effectiveness threshold for Zhejiang Province (< 3 times GDP per capita), suggesting that the programme is cost effective.


  1. Zeng Y, et al. An economic evaluation of the current measles vaccination program: A case study in Zhejiang Province, east China. Vaccine : 27 Apr 2019. Available from: URL:

Copyright information

© Springer International Publishing AG 2019

Personalised recommendations