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Cost-Effectiveness of Tenofovir Alafenamide for Treatment of Chronic Hepatitis B in Canada

  • Feng Tian
  • Sherilyn K. D. Houle
  • Mhd. Wasem Alsabbagh
  • William W. L. WongEmail author
Original Research Article

Abstract

Background/Aim

Tenofovir alafenamide (TAF) has been approved for treating chronic hepatitis B (CHB) due to a proposed better safety profile in comparison with current therapies. We evaluated the cost effectiveness of TAF and other available treatment options for hepatitis B envelope antigen (HBeAg)-positive and HBeAg-negative CHB patients from a Canadian provincial Ministry of Health perspective.

Methods

A state-transition model based on the published literature was developed to compare treatment strategies involving entecavir (ETV), tenofovir disoproxil fumarate (TDF), and TAF. It adopted a lifetime time horizon. Outcomes measured were predicted number of liver-related deaths, costs, quality-adjusted life-years (QALYs), and incremental cost-effectiveness ratios (ICERs).

Results

For HBeAg-positive patients, TAF followed by ETV generated an additional 0.16 QALYs/person at an additional cost of Can$14,836.18 with an ICER of Can$94,142.71/QALY compared with TDF followed by ETV. Of the iterations, 28.7% showed that it is the optimal strategy with a Can$50,000 willingness-to-pay threshold. For HBeAg-negative patients, ETV followed by TAF would prevent an additional 13 liver-related deaths per 1000 CHB patients compared with TDF, followed by ETV. It generated an additional 0.13 QALYs/person at an additional cost of Can$59,776.53 with an ICER of Can$461,162.21/QALY compared with TDF, followed by ETV. TAF-containing strategies are unlikely to be a rational choice in either case. The results were sensitive to the HBeAg seroconversion rates and viral suppression rates of the treatments.

Conclusions

Our analysis suggests that TAF is not cost effective at its current cost. A 33.4% reduction in price would be required to make it cost effective for HBeAg-positive patients with a Can$50,000 willingness-to-pay threshold.

Notes

Acknowledgements

Dr Wong’s research program was supported by Canadian Institutes of Health Research (CIHR), Natural Sciences and Engineering Research Council (NSERC), and Ontario Ministry of Research, Innovation, and Science Early Researcher Award.

Author Contributions

FT implemented the model, collected and analyzed the data, and drafted the manuscript. SKH and WA contributed to analysis of the data and interpretation of the results. WW contributed to the design of the study, analysis, and interpretation of the data. All authors contributed in the revision of the manuscript and gave final approval for the version to be published.

Compliance with Ethical Standards

Funding/Grant Support

This work was supported by an Ontario Ministry of Research, Innovation, and Science Early Researcher Award that was awarded to WW.

Conflict of interest

WW received a research grant from the Canadian Liver Foundation. FT, SAK, and WA declared no conflicts of interest.

Supplementary material

40273_2019_852_MOESM1_ESM.docx (1 mb)
Supplementary material 1 (DOCX 1037 kb)

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.School of Pharmacy, Faculty of ScienceUniversity of WaterlooKitchenerCanada

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