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PharmacoEconomics

, Volume 33, Issue 7, pp 673–689 | Cite as

The Epidemiology of Obesity: A Big Picture

  • Adela HrubyEmail author
  • Frank B. Hu
Review Article

Abstract

The epidemic of overweight and obesity presents a major challenge to chronic disease prevention and health across the life course around the world. Fueled by economic growth, industrialization, mechanized transport, urbanization, an increasingly sedentary lifestyle, and a nutritional transition to processed foods and high-calorie diets over the last 30 years, many countries have witnessed the prevalence of obesity in its citizens double and even quadruple. A rising prevalence of childhood obesity, in particular, forebodes a staggering burden of disease in individuals and healthcare systems in the decades to come. A complex, multifactorial disease, with genetic, behavioral, socioeconomic, and environmental origins, obesity raises the risk of debilitating morbidity and mortality. Relying primarily on epidemiologic evidence published within the last decade, this non-exhaustive review discusses the extent of the obesity epidemic, its risk factors—known and novel—, sequelae, and economic impact across the globe.

Keywords

Obesity Childhood Obesity Excess Body Weight Fast Food Restaurant Obesity Risk 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

The authors declare no conflict of interest. AH is supported by an American Diabetes Association Mentor-Based Postdoctoral Fellowship award. FH is supported by NIH grants DK51158, HL60712, P30 DK46200, and U54CA155626. The authors broadly thank the researchers in this field for their consistent and tireless work in illuminating the etiology, sequelae, and solutions to this complex condition.

Author Contributions

AH wrote the first draft of the paper. AH and FH contributed to the writing and revised and edited the paper. AH is the final guarantor of this work and takes full responsibility for its contents. Both authors read and approved the final manuscript.

References

  1. 1.
    American Medical Association. AMA adopts new policies on second day of voting at annual meeting [Internet]. 2013 [cited 2014 Apr 7]. Available from: http://www.ama-assn.org/ama/pub/news/news/2013/2013-06-18-new-ama-policies-annual-meeting.page.
  2. 2.
    Ng M, Fleming T, Robinson M, Thomson B, Graetz N, Margono C, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. The Lancet [Internet]. (0). Available from: http://www.sciencedirect.com/science/article/pii/S0140673614604608.
  3. 3.
    Stevens GA, Singh GM, Lu Y, Danaei G, Lin JK, Finucane MM, et al. National, regional, and global trends in adult overweight and obesity prevalences. Popul Health Metr. 2012;10(1):22.PubMedCentralPubMedGoogle Scholar
  4. 4.
    Kelly T, Yang W, Chen C-S, Reynolds K, He J. Global burden of obesity in 2005 and projections to 2030. Int J Obes. 2008;32(9):1431–7.Google Scholar
  5. 5.
    Wang Y, Beydoun MA, Liang L, Caballero B, Kumanyika SK. Will all Americans become overweight or obese? Estimating the progression and cost of the US obesity epidemic. Obesity (Silver Spring). 2008;16(10):2323–30.Google Scholar
  6. 6.
    Hu FB. Obesity epidemiology. Oxford: Oxford University Press; 2008. p. 498.Google Scholar
  7. 7.
    Hu FB. Obesity and mortality: watch your waist, not just your weight. Arch Intern Med. 2007;167(9):875.PubMedGoogle Scholar
  8. 8.
    Alberti KGMM, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, et al. Harmonizing the Metabolic Syndrome: a Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009;120(16):1640–5.PubMedGoogle Scholar
  9. 9.
    Alberti KGM, Zimmet P, Shaw J. The metabolic syndrome—a new worldwide definition. Lancet. 2005;366(9491):1059–62.PubMedGoogle Scholar
  10. 10.
    WHO Multicentre Growth Reference Study Group. WHO Child Growth Standards based on length/height, weight and age. Acta Paediatr Suppl. 2006;450:76–85.Google Scholar
  11. 11.
    De Onis M, Onyango AW, Borghi E, Siyam A, Nishida C, Siekmann J. Development of a WHO growth reference for school-aged children and adolescents. Bull World Health Organ. 2007;85(9):660–7.PubMedCentralPubMedGoogle Scholar
  12. 12.
    Kuczmarski RJ, Ogden CL, Grummer-Strawn LM, Flegal KM, Guo SS, Wei R, et al. CDC growth charts: United States. Adv Data. 2000;314:1–27.PubMedGoogle Scholar
  13. 13.
    Barlow SE, The Expert Committee. Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Pediatrics. 2007;120(Supplement 4):S164–92.PubMedGoogle Scholar
  14. 14.
    Flegal KM, Wei R, Ogden CL, Freedman DS, Johnson CL, Curtin LR. Characterizing extreme values of body mass index-for-age by using the 2000 Centers for Disease Control and Prevention growth charts. Am J Clin Nutr. 2009;90(5):1314–20.PubMedGoogle Scholar
  15. 15.
    Grummer-Strawn LM, Reinold C, Krebs NF, Centers for Disease Control and Prevention (CDC). Use of World Health Organization and CDC growth charts for children aged 0–59 months in the United States. MMWR Recomm Rep. 2010;59(RR-9):1–15.PubMedGoogle Scholar
  16. 16.
    Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of childhood and adult obesity in the United States, 2011–2012. JAMA. 2014;311(8):806.PubMedGoogle Scholar
  17. 17.
    Flegal KM, Carroll MD, Kuczmarski RJ, Johnson CL. Overweight and obesity in the United States: prevalence and trends, 1960–1994. Int J Obes Relat Metab Disord. 1998;22(1):39–47.PubMedGoogle Scholar
  18. 18.
    Von Ruesten A, Steffen A, Floegel A, van der A DL, Masala G, Tjønneland A, et al. Trend in obesity prevalence in European adult cohort populations during follow-up since 1996 and their predictions to 2015. PloS One. 2011;6(11):e27455.Google Scholar
  19. 19.
    Berghöfer A, Pischon T, Reinhold T, Apovian CM, Sharma AM, Willich SN. Obesity prevalence from a European perspective: a systematic review. BMC Public Health. 2008;8(1):200.PubMedCentralPubMedGoogle Scholar
  20. 20.
    Skinner AC, Skelton JA. Prevalence and Trends in Obesity and Severe Obesity Among Children in the United States, 1999–2012. JAMA Pediatr [Internet]. 2014 Apr 7 [cited 2014 Apr 8]; Available from: http://archpedi.jamanetwork.com/article.aspx?doi=10.1001/jamapediatrics.2014.21.
  21. 21.
    Wijnhoven TMA, van Raaij JMA, Spinelli A, Rito AI, Hovengen R, Kunesova M, et al. WHO European Childhood Obesity Surveillance Initiative 2008: weight, height and body mass index in 6–9-year-old children. Pediatr Obes. 2013;8(2):79–97.PubMedGoogle Scholar
  22. 22.
    Barquera S, Campos-Nonato I, Hernández-Barrera L, Pedroza A, Rivera-Dommarco JA. Prevalence of obesity in Mexican adults 2000–2012. Salud Publica Mex. 2013;55(Suppl 2):S151–60.PubMedGoogle Scholar
  23. 23.
    Liang Y-J, Xi B, Song A-Q, Liu J-X, Mi J. Trends in general and abdominal obesity among Chinese children and adolescents 1993–2009: general and abdominal obesity in Chinese children. Pediatr Obes. 2012;7(5):355–64.PubMedCentralPubMedGoogle Scholar
  24. 24.
    Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet. 2010;42(11):937–48.PubMedCentralPubMedGoogle Scholar
  25. 25.
    Hindorff LA, Sethupathy P, Junkins HA, Ramos EM, Mehta JP, Collins FS, et al. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci. 2009;106(23):9362–7.PubMedCentralPubMedGoogle Scholar
  26. 26.
    Neel JV. Diabetes mellitus: a “thrifty” genotype rendered detrimental by “progress”? Am J Hum Genet. 1962;14:353–62.PubMedCentralPubMedGoogle Scholar
  27. 27.
    Kilpeläinen TO, Qi L, Brage S, Sharp SJ, Sonestedt E, Demerath E, et al. Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. Lewis C, editor. PLoS Med. 2011;8(11):e1001116.Google Scholar
  28. 28.
    Rankinen T, Rice T, Teran-Garcia M, Rao DC, Bouchard C. FTO genotype is associated with exercise training-induced changes in body composition. Obesity (Silver Spring). 2010;18(2):322–6.Google Scholar
  29. 29.
    Scott RA, Bailey MES, Moran CN, Wilson RH, Fuku N, Tanaka M, et al. FTO genotype and adiposity in children: physical activity levels influence the effect of the risk genotype in adolescent males. Eur J Hum Genet. 2010;18(12):1339–43.PubMedCentralPubMedGoogle Scholar
  30. 30.
    Ravelli AC, van der Meulen JH, Osmond C, Barker DJ, Bleker OP. Obesity at the age of 50 y in men and women exposed to famine prenatally. Am J Clin Nutr. 1999;70(5):811–6.PubMedGoogle Scholar
  31. 31.
    Drake AJ, Reynolds RM. Impact of maternal obesity on offspring obesity and cardiometabolic disease risk. Reproduction. 2010;140(3):387–98.PubMedGoogle Scholar
  32. 32.
    Gaillard R, Steegers EAP, Duijts L, Felix JF, Hofman A, Franco OH, et al. Childhood cardiometabolic outcomes of maternal obesity during pregnancy: the generation R Study. Hypertension. 2014;63(4):683–91.PubMedGoogle Scholar
  33. 33.
    Bammann K, Peplies J, De Henauw S, Hunsberger M, Molnar D, Moreno LA, et al. Early life course risk factors for childhood obesity: the IDEFICS Case-Control Study. Bruce A, editor. PLoS One. 2014;9(2):e86914.Google Scholar
  34. 34.
    Northstone K, Golding J, Davey Smith G, Miller LL, Pembrey M. Prepubertal start of father’s smoking and increased body fat in his sons: further characterisation of paternal transgenerational responses. Eur J Hum Genet. 2014;22(12):1382-6.Google Scholar
  35. 35.
    Janesick AS, Shioda T, Blumberg B. Transgenerational inheritance of prenatal obesogen exposure. Mol Cell Endocrinol. Epub 2014 Sep 15.Google Scholar
  36. 36.
    De Cock M, van de Bor M. Obesogenic effects of endocrine disruptors, what do we know from animal and human studies? Environ Int. 2014;70:15–24.PubMedGoogle Scholar
  37. 37.
    Dabelea D, Harrod CS. Role of developmental overnutrition in pediatric obesity and type 2 diabetes. Nutr Rev. 2013;71:S62–7.PubMedGoogle Scholar
  38. 38.
    Mokdad AH, Marks JS, Stroup DF, Gerberding JL. Actual causes of death in the United States, 2000. JAMA. 2004;291(10):1238–45.PubMedGoogle Scholar
  39. 39.
    Hill JO, Wyatt HR, Peters JC. Energy balance and obesity. Circulation. 2012;126(1):126–32.PubMedCentralPubMedGoogle Scholar
  40. 40.
    Wadden TA, Webb VL, Moran CH, Bailer BA. Lifestyle modification for obesity: new developments in diet, physical activity, and behavior therapy. Circulation. 2012;125(9):1157–70.PubMedCentralPubMedGoogle Scholar
  41. 41.
    Shai I, Schwarzfuchs D, Henkin Y, Shahar DR, Witkow S, Greenberg I, et al. Weight loss with a low-carbohydrate, mediterranean, or low-fat diet. N Engl J Med. 2008;359(3):229–41.PubMedGoogle Scholar
  42. 42.
    Gardner CD. Comparison of the Atkins, Zone, Ornish, and LEARN diets for change in weight and related risk factors among overweight premenopausal women: the A TO Z Weight Loss Study: a randomized trial. JAMA. 2007;297(9):969.PubMedGoogle Scholar
  43. 43.
    Sacks FM, Bray GA, Carey VJ, Smith SR, Ryan DH, Anton SD, et al. Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates. N Engl J Med. 2009;360(9):859–73.PubMedCentralPubMedGoogle Scholar
  44. 44.
    Mozaffarian D, Hao T, Rimm EB, Willett WC, Hu FB. Changes in diet and lifestyle and long-term weight gain in women and men. N Engl J Med. 2011;364(25):2392–404.PubMedCentralPubMedGoogle Scholar
  45. 45.
    Malik VS, Popkin BM, Bray GA, Despres J-P, Hu FB. Sugar-sweetened beverages, obesity, type 2 diabetes mellitus, and cardiovascular disease risk. Circulation. 2010;121(11):1356–64.PubMedCentralPubMedGoogle Scholar
  46. 46.
    Malik VS, Pan A, Willett WC, Hu FB. Sugar-sweetened beverages and weight gain in children and adults: a systematic review and meta-analysis. Am J Clin Nutr. 2013;98(4):1084–102.PubMedCentralPubMedGoogle Scholar
  47. 47.
    Hu FB. Resolved: there is sufficient scientific evidence that decreasing sugar-sweetened beverage consumption will reduce the prevalence of obesity and obesity-related diseases. Obes Rev. 2013;14(8):606–19.PubMedGoogle Scholar
  48. 48.
    Gallagher J. Mexico restricts soft drink TV ads to fight obesity [Internet]. BBC News. 2014 [cited 2014 Jul 16]. Available from: http://www.bbc.com/news/world-latin-america-28325105.
  49. 49.
    New York City bans supersize sodas [Internet]. BBC News. 2012 [cited 2014 Jul 21]. Available from: http://www.bbc.com/news/world-us-canada-19593012.
  50. 50.
    2008 Physical Activity Guidelines for Americans [Internet]. [cited 2014 Apr 21]. Available from: http://www.health.gov/paguidelines/guidelines/.
  51. 51.
    Donnelly JE, Blair SN, Jakicic JM, Manore MM, Rankin JW, Smith BK, et al. American College of Sports Medicine Position Stand. Appropriate physical activity intervention strategies for weight loss and prevention of weight regain for adults. Med Sci Sports Exerc. 2009;41(2):459–71.PubMedGoogle Scholar
  52. 52.
    Patel SR, Hu FB. Short sleep duration and weight gain: a systematic review. Obesity. 2008;16(3):643–53.PubMedCentralPubMedGoogle Scholar
  53. 53.
    Watanabe M, Kikuchi H, Tanaka K, Takahashi M. Association of short sleep duration with weight gain and obesity at 1-year follow-up: a large-scale prospective study. Sleep. 2010;33(2):161–7.PubMedCentralPubMedGoogle Scholar
  54. 54.
    Kobayashi D, Takahashi O, Deshpande GA, Shimbo T, Fukui T. Association between weight gain, obesity, and sleep duration: a large-scale 3-year cohort study. Sleep Breath. 2012;16(3):829–33.PubMedGoogle Scholar
  55. 55.
    Lyytikäinen P, Rahkonen O, Lahelma E, Lallukka T. Association of sleep duration with weight and weight gain: a prospective follow-up study. J Sleep Res. 2011;20(2):298–302.PubMedGoogle Scholar
  56. 56.
    Hu FB. Television watching and other sedentary behaviors in relation to risk of obesity and type 2 diabetes mellitus in women. JAMA. 2003;289(14):1785.PubMedGoogle Scholar
  57. 57.
    Boone JE, Gordon-Larsen P, Adair LS, Popkin BM. Screen time and physical activity during adolescence: longitudinal effects on obesity in young adulthood. Int J Behav Nutr Phys Act. 2007;4(1):26.PubMedCentralPubMedGoogle Scholar
  58. 58.
    Martínez-González MA, Martínez JA, Hu FB, Gibney MJ, Kearney J. Physical inactivity, sedentary lifestyle and obesity in the European Union. Int J Obes Relat Metab Disord. 1999;23(11):1192–201.PubMedGoogle Scholar
  59. 59.
    Levine JA. Poverty and obesity in the U.S. Diabetes. 2011;60(11):2667–8.PubMedCentralPubMedGoogle Scholar
  60. 60.
    Koh KA, Hoy JS, O’Connell JJ, Montgomery P. The hunger-obesity paradox: obesity in the homeless. J Urban Health. 2012;89(6):952–64.PubMedCentralPubMedGoogle Scholar
  61. 61.
    Tsai J, Rosenheck RA. Obesity among chronically homeless adults: is it a problem? Public Health Rep. 2013;128(1):29–36.PubMedCentralPubMedGoogle Scholar
  62. 62.
    Devaux M, Sassi F. Social inequalities in obesity and overweight in 11 OECD countries. Eur J Public Health. 2013;23(3):464–9.PubMedGoogle Scholar
  63. 63.
    Aitsi-Selmi A, Bell R, Shipley MJ, Marmot MG. Education modifies the association of wealth with obesity in women in middle-income but not low-income countries: an interaction study using seven national datasets, 2005–2010. PloS One. 2014;9(3):e90403.PubMedCentralPubMedGoogle Scholar
  64. 64.
    Malik VS, Willett WC, Hu FB. Global obesity: trends, risk factors and policy implications. Nat Rev Endocrinol. 2013;9(1):13–27.PubMedGoogle Scholar
  65. 65.
    Regnier SM, Sargis RM. Adipocytes under assault: environmental disruption of adipose physiology. Biochim Biophys Acta. 2014;1842(3):520–33.PubMedCentralPubMedGoogle Scholar
  66. 66.
    Papas MA, Alberg AJ, Ewing R, Helzlsouer KJ, Gary TL, Klassen AC. The built environment and obesity. Epidemiol Rev. 2007;29:129–43.PubMedGoogle Scholar
  67. 67.
    Larson NI, Story MT, Nelson MC. Neighborhood environments: disparities in access to healthy foods in the U.S. Am J Prev Med. 2009;36(1):74–81.PubMedGoogle Scholar
  68. 68.
    Holsten JE. Obesity and the community food environment: a systematic review. Public Health Nutr. 2009;12(3):397–405.PubMedGoogle Scholar
  69. 69.
    McCormack GR, Shiell A. In search of causality: a systematic review of the relationship between the built environment and physical activity among adults. Int J Behav Nutr Phys Act. 2011;8:125.PubMedCentralPubMedGoogle Scholar
  70. 70.
    Morland KB, Evenson KR. Obesity prevalence and the local food environment. Health Place. 2009;15(2):491–5.PubMedGoogle Scholar
  71. 71.
    Sallis JF, Floyd MF, Rodríguez DA, Saelens BE. Role of built environments in physical activity, obesity, and cardiovascular disease. Circulation. 2012;125(5):729–37.PubMedCentralPubMedGoogle Scholar
  72. 72.
    Durand CP, Andalib M, Dunton GF, Wolch J, Pentz MA. A systematic review of built environment factors related to physical activity and obesity risk: implications for smart growth urban planning. Obes Rev. 2011;12(5):e173–82.PubMedCentralPubMedGoogle Scholar
  73. 73.
    Berry TR, Spence JC, Blanchard CM, Cutumisu N, Edwards J, Selfridge G. A longitudinal and cross-sectional examination of the relationship between reasons for choosing a neighbourhood, physical activity and body mass index. Int J Behav Nutr Phys Act. 2010;7:57.PubMedCentralPubMedGoogle Scholar
  74. 74.
    Boone-Heinonen J, Diez-Roux AV, Goff DC, Loria CM, Kiefe CI, Popkin BM, et al. The neighborhood energy balance equation: does neighborhood food retail environment + physical activity environment = obesity? The CARDIA study. PloS One. 2013;8(12):e85141.PubMedCentralPubMedGoogle Scholar
  75. 75.
    Auchincloss AH, Mujahid MS, Shen M, Michos ED, Whitt-Glover MC, Diez Roux AV. Neighborhood health-promoting resources and obesity risk (the multi-ethnic study of atherosclerosis). Obesity (Silver Spring). 2013;21(3):621–8.Google Scholar
  76. 76.
    McAllister EJ, Dhurandhar NV, Keith SW, Aronne LJ, Barger J, Baskin M, et al. Ten putative contributors to the obesity epidemic. Crit Rev Food Sci Nutr. 2009;49(10):868–913.PubMedCentralPubMedGoogle Scholar
  77. 77.
    Parra-Rojas I, Del Moral-Hernández O, Salgado-Bernabé AB, Guzmán-Guzmán IP, Salgado-Goytia L, Muñoz-Valle JF. Adenovirus-36 seropositivity and its relation with obesity and metabolic profile in children. Int J Endocrinol. 2013;2013:463194.PubMedCentralPubMedGoogle Scholar
  78. 78.
    Atkinson RL, Dhurandhar NV, Allison DB, Bowen RL, Israel BA, Albu JB, et al. Human adenovirus-36 is associated with increased body weight and paradoxical reduction of serum lipids. Int J Obes. 2005;29(3):281–6.Google Scholar
  79. 79.
    Almgren M, Atkinson R, He J, Hilding A, Hagman E, Wolk A, et al. Adenovirus-36 is associated with obesity in children and adults in Sweden as determined by rapid ELISA. PloS One. 2012;7(7):e41652.PubMedCentralPubMedGoogle Scholar
  80. 80.
    Clarke SF, Murphy EF, Nilaweera K, Ross PR, Shanahan F, O’Toole PW, et al. The gut microbiota and its relationship to diet and obesity: new insights. Gut Microbes. 2012;3(3):186–202.PubMedCentralPubMedGoogle Scholar
  81. 81.
    Ley RE, Turnbaugh PJ, Klein S, Gordon JI. Microbial ecology: human gut microbes associated with obesity. Nature. 2006;444(7122):1022–3.PubMedGoogle Scholar
  82. 82.
    David LA, Maurice CF, Carmody RN, Gootenberg DB, Button JE, Wolfe BE, et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature. 2013;505(7484):559–63.PubMedCentralPubMedGoogle Scholar
  83. 83.
    Wu GD, Chen J, Hoffmann C, Bittinger K, Chen Y-Y, Keilbaugh SA, et al. Linking long-term dietary patterns with gut microbial enterotypes. Science. 2011;334(6052):105–8.PubMedCentralPubMedGoogle Scholar
  84. 84.
    Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006;444(7122):1027–131.PubMedGoogle Scholar
  85. 85.
    Shen J, Obin MS, Zhao L. The gut microbiota, obesity and insulin resistance. Obesity. 2013;34(1):39–58.Google Scholar
  86. 86.
    Christakis NA, Fowler JH. The spread of obesity in a large social network over 32 years. N Engl J Med. 2007;357(4):370–9.PubMedGoogle Scholar
  87. 87.
    Leroux JS, Moore S, Dubé L. Beyond the “I” in the obesity epidemic: a review of social relational and network interventions on obesity. J Obes. 2013;2013:1–10.Google Scholar
  88. 88.
    Peeters A, Barendregt JJ, Willekens F, Mackenbach JP, Al Mamun A, Bonneux L, et al. Obesity in adulthood and its consequences for life expectancy: a life-table analysis. Ann Intern Med. 2003;138(1):24–32.PubMedGoogle Scholar
  89. 89.
    Prospective Studies Collaboration, Whitlock G, Lewington S, Sherliker P, Clarke R, Emberson J, et al. Body-mass index and cause-specific mortality in 900,000 adults: collaborative analyses of 57 prospective studies. Lancet. 2009;373(9669):1083–96.PubMedCentralGoogle Scholar
  90. 90.
    Berrington de Gonzalez A, Hartge P, Cerhan JR, Flint AJ, Hannan L, MacInnis RJ, et al. Body-mass index and mortality among 1.46 million white adults. N Engl J Med. 2010;363(23):2211–9.PubMedGoogle Scholar
  91. 91.
    Chen Y, Copeland WK, Vedanthan R, Grant E, Lee JE, Gu D, et al. Association between body mass index and cardiovascular disease mortality in east Asians and south Asians: pooled analysis of prospective data from the Asia Cohort Consortium. BMJ. 2013;347:f5446.PubMedCentralPubMedGoogle Scholar
  92. 92.
    Tsai SP, Donnelly RP, Wendt JK. Obesity and mortality in a prospective study of a middle-aged industrial population. J Occup Environ Med. 2006;48(1):22–7.PubMedGoogle Scholar
  93. 93.
    Adams KF, Schatzkin A, Harris TB, Kipnis V, Mouw T, Ballard-Barbash R, et al. Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old. N Engl J Med. 2006;355(8):763–78.PubMedGoogle Scholar
  94. 94.
    Adams KF, Leitzmann MF, Ballard-Barbash R, Albanes D, Harris TB, Hollenbeck A, et al. Body mass and weight change in adults in relation to mortality risk. Am J Epidemiol. 2014;179(2):135–44.PubMedCentralPubMedGoogle Scholar
  95. 95.
    Calle EE, Thun MJ, Petrelli JM, Rodriguez C, Heath CW. Body-mass index and mortality in a prospective cohort of U.S. adults. N Engl J Med. 1999;341(15):1097–105.PubMedGoogle Scholar
  96. 96.
    Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med. 2003;348(17):1625–38.PubMedGoogle Scholar
  97. 97.
    Park Y, Wang S, Kitahara CM, Moore SC, Berrington de Gonzalez A, Bernstein L, et al. Body mass index and risk of death in Asian Americans. Am J Public Health. 2014;104(3):520–5.PubMedCentralPubMedGoogle Scholar
  98. 98.
    American Diabetes Association. Standards of medical care in diabetes—2012. Diabetes Care. 2012;35(Supplement 1):S11–63.Google Scholar
  99. 99.
    Abdullah A, Peeters A, de Courten M, Stoelwinder J. The magnitude of association between overweight and obesity and the risk of diabetes: a meta-analysis of prospective cohort studies. Diabetes Res Clin Pract. 2010;89(3):309–19.PubMedGoogle Scholar
  100. 100.
    Reilly JJ, Kelly J. Long-term impact of overweight and obesity in childhood and adolescence on morbidity and premature mortality in adulthood: systematic review. Int J Obes. 2011;35(7):891–8.Google Scholar
  101. 101.
    Kodama S, Horikawa C, Fujihara K, Yoshizawa S, Yachi Y, Tanaka S, et al. Quantitative relationship between body weight gain in adulthood and incident type 2 diabetes: a meta-analysis: body weight gain and type 2 diabetes. Obes Rev. 2014;15(3):202–14.PubMedGoogle Scholar
  102. 102.
    Narayan KMV, Boyle JP, Thompson TJ, Gregg EW, Williamson DF. Effect of BMI on lifetime risk for diabetes in the U.S. Diabetes Care. 2007;30(6):1562–6.PubMedGoogle Scholar
  103. 103.
    National Diabetes Information Clearinghouse, US Department of Health and Human Services. Diabetes Fact Sheet [Internet]. [cited 2014 Apr 24]. Available from: http://diabetes.niddk.nih.gov/dm/pubs/overview/.
  104. 104.
    Bell JA, Kivimaki M, Hamer M. Metabolically healthy obesity and risk of incident type 2 diabetes: a meta-analysis of prospective cohort studies. Obes Rev. 2014;15(6):504-15.Google Scholar
  105. 105.
    Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2095–128.PubMedGoogle Scholar
  106. 106.
    Flint AJ, Hu FB, Glynn RJ, Caspard H, Manson JE, Willett WC, et al. Excess weight and the risk of incident coronary heart disease among men and women. Obesity. 2010;18(2):377–83.PubMedCentralPubMedGoogle Scholar
  107. 107.
    Kramer CK, Zinman B, Retnakaran R. Are metabolically healthy overweight and obesity benign conditions?: a systematic review and meta-analysis. Ann Intern Med. 2013;159(11):758.PubMedGoogle Scholar
  108. 108.
    Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration (BMI Mediated Effects), Lu Y, Hajifathalian K, Ezzati M, Woodward M, Rimm EB, et al. Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1.8 million participants. Lancet. 2014;383(9921):970–83.Google Scholar
  109. 109.
    Juonala M, Magnussen CG, Berenson GS, Venn A, Burns TL, Sabin MA, et al. Childhood adiposity, adult adiposity, and cardiovascular risk factors. N Engl J Med. 2011;365(20):1876–85.PubMedGoogle Scholar
  110. 110.
    Polednak AP. Estimating the number of U.S. incident cancers attributable to obesity and the impact on temporal trends in incidence rates for obesity-related cancers. Cancer Detect Prev. 2008;32(3):190–9.PubMedGoogle Scholar
  111. 111.
    Vainio H, Bianchini F. Weight control and physical activity. Lyon: IARC Press; 2002.Google Scholar
  112. 112.
    Larsson SC, Wolk A. Obesity and the risk of gallbladder cancer: a meta-analysis. Br J Cancer [Internet]. 2007 Mar 20 [cited 2014 Apr 24]; Available from: http://www.nature.com/doifinder/10.1038/sj.bjc.6603703.
  113. 113.
    Larsson SC, Wolk A. Overweight, obesity and risk of liver cancer: a meta-analysis of cohort studies. Br J Cancer. 2007;97(7):1005–8.PubMedCentralPubMedGoogle Scholar
  114. 114.
    Olsen CM, Green AC, Sadeghi S, Kolahdooz F, Webb PM. Obesity and the risk of epithelial ovarian cancer: a systematic review and meta-analysis. Eur J Cancer. 2007;43(4):690–709.PubMedGoogle Scholar
  115. 115.
    Discacciati A, Orsini N, Wolk A. Body mass index and incidence of localized and advanced prostate cancer—a dose-response meta-analysis of prospective studies. Ann Oncol. 2012;23(7):1665–71.PubMedGoogle Scholar
  116. 116.
    Larsson SC, Wolk A. Overweight and obesity and incidence of leukemia: a meta-analysis of cohort studies. Int J Cancer. 2008;122(6):1418–21.PubMedGoogle Scholar
  117. 117.
    Glance LG, Li Y, Osler TM, Mukamel DB, Dick AW. Impact of obesity on mortality and complications in trauma patients. Ann Surg. 2014;259(3):576–81.PubMedGoogle Scholar
  118. 118.
    Liu T, Chen J, Bai X, Zheng G, Gao W. The effect of obesity on outcomes in trauma patients: a meta-analysis. Injury. 2013;44(9):1145–52.PubMedGoogle Scholar
  119. 119.
    Huttunen R, Syrjänen J. Obesity and the risk and outcome of infection. Int J Obes. 2013;37(3):333–40.Google Scholar
  120. 120.
    Young KM, Gray CM, Bekker L-G. Is obesity a risk factor for vaccine non-responsiveness? Ahuja SK, editor. PLoS One. 2013;8(12):e82779.Google Scholar
  121. 121.
    Raji CA, Ho AJ, Parikshak NN, Becker JT, Lopez OL, Kuller LH, et al. Brain structure and obesity. Hum Brain Mapp. 2010;31(3):353-64.Google Scholar
  122. 122.
    Reinert KRS, Po’e EK, Barkin SL. The relationship between executive function and obesity in children and adolescents: a systematic literature review. J Obes. 2013;2013:1–10.Google Scholar
  123. 123.
    Anstey KJ, Cherbuin N, Budge M, Young J. Body mass index in midlife and late-life as a risk factor for dementia: a meta-analysis of prospective studies. Obes Rev. 2011;12(5):e426–37.PubMedGoogle Scholar
  124. 124.
    Lindholm V, Lahti J, Rahkonen O, Lahelma E, Lallukka T. Joint association of physical activity and body weight with subsequent physical and mental functioning: a follow-up study. BMC Public Health. 2013;13(1):197.PubMedCentralGoogle Scholar
  125. 125.
    Cawley J, Meyerhoefer C. The medical care costs of obesity: an instrumental variables approach. J Health Econ. 2012;31(1):219–30.PubMedGoogle Scholar
  126. 126.
    Mason RJ, Moroney JR, Berne TV. The cost of obesity for nonbariatric inpatient operative procedures in the United States: national cost estimates obese versus nonobese patients. Ann Surg. 2013;258(4):541–51 (discussion 551–3).PubMedGoogle Scholar
  127. 127.
    Kleinman N, Abouzaid S, Andersen L, Wang Z, Powers A. Cohort analysis assessing medical and nonmedical cost associated with obesity in the workplace. J Occup Environ Med. 2014;56(2):161–70.PubMedGoogle Scholar
  128. 128.
    Finkelstein EA, Graham WCK, Malhotra R. Lifetime direct medical costs of childhood obesity. Pediatrics [Internet]. 2014 Apr 7 [cited 2014 Apr 22]; Available from: http://pediatrics.aappublications.org/cgi/doi/10.1542/peds.2014-0063.
  129. 129.
    Müller-Riemenschneider F, Reinhold T, Berghöfer A, Willich SN. Health-economic burden of obesity in Europe. Eur J Epidemiol. 2008;23(8):499–509.PubMedGoogle Scholar
  130. 130.
    Von Lengerke T, Krauth C. Economic costs of adult obesity: a review of recent European studies with a focus on subgroup-specific costs. Maturitas. 2011;69(3):220–9.Google Scholar
  131. 131.
    Bahia L, Coutinho ES, Barufaldi L, de Azevedo Abreu G, Malhão T, Ribeiro de Souza C, et al. The costs of overweight and obesity-related diseases in the Brazilian public health system: cross-sectional study. BMC Public Health. 2012;12(1):440.PubMedCentralPubMedGoogle Scholar
  132. 132.
    Rtveladze K, Marsh T, Webber L, Kilpi F, Levy D, Conde W, et al. Health and economic burden of obesity in Brazil. PloS One. 2013;8(7):e68785.PubMedCentralPubMedGoogle Scholar
  133. 133.
    Rtveladze K, Marsh T, Barquera S, Sanchez Romero LM, Levy D, Melendez G, et al. Obesity prevalence in Mexico: impact on health and economic burden. Public Health Nutr. 2014;17(01):233–9.PubMedGoogle Scholar
  134. 134.
    Marketdata Enterprises, Inc. The U.S. weight loss market: 2014 status report & market research [Internet]. 2014 [cited 2014 Apr 23]. Available from: http://www.marketresearch.com/Marketdata-Enterprises-Inc-v416/Weight-Loss-Status-Forecast-8016030/.
  135. 135.
    National Institutes of Health, National Heart, Lung, and Blood Institute. Obesity education initiative: clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: executive summary. Expert panel on the identification, evaluation, and treatment of overweight in adults. [Internet]. Bethesda: U.S. Department of Health and Human Services; 1998 Oct [cited 2014 Apr 1]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK2003/.
  136. 136.
    Huang TT, Drewnosksi A, Kumanyika S, Glass TA. A systems-oriented multilevel framework for addressing obesity in the 21st century. Prev Chronic Dis. 2009;6(3):A82.PubMedCentralPubMedGoogle Scholar
  137. 137.
    Cornelis MC, Hu FB. Systems epidemiology: a new direction in nutrition and metabolic disease research. Curr Nutr Rep. 2013;2(4).Google Scholar
  138. 138.
    U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health. The Health Consequences of Smoking —50 Years of Progress: a Report of the Surgeon General. [Internet]. Atlanta: U.S. Department of Health and Human Services; 2014 [cited 2014 Apr 1]. Available from: http://www.surgeongeneral.gov/library/reports/50-years-of-progress/.
  139. 139.
    World Health Organization. Obesity: preventing and managing the global epidemic: report of a WHO consultation. Geneva: World Health Organization; 2000. p. 253.Google Scholar
  140. 140.
    Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ. 2000;320(7244):1240.PubMedCentralPubMedGoogle Scholar
  141. 141.
    Fryar CD, Carroll MD, Ogden CL. NCHS Health E Stat—Overweight, Obesity, and Extreme Obesity Among Adults: United States, Trends 1960–1962 Through 2009–2010 [Internet]. [cited 2014 Feb 26]. Available from: http://www.cdc.gov/nchs/data/hestat/obesity_adult_09_10/obesity_adult_09_10.htm.

Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  1. 1.Department of NutritionHarvard School of Public HealthBostonUSA

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