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Attributes Used for Cancer Screening Discrete Choice Experiments: A Systematic Review

The Patient - Patient-Centered Outcomes Research volume 15, pages 269–285 (2022)Cite this article

A Correction to this article was published on 12 November 2021

This article has been updated

Abstract

Background

Evidence from discrete choice experiments can be used to enrich understanding of preferences, inform the (re)design of screening programmes and/or improve communication within public campaigns about the benefits and harms of screening. However, reviews of screening discrete choice experiments highlight significant discrepancies between stated choices and real choices, particularly regarding willingness to undergo cancer screening. The identification and selection of attributes and associated levels is a fundamental component of designing a discrete choice experiment. Misspecification or misinterpretation of attributes may lead to non-compensatory behaviours, attribute non-attendance and responses that lack external validity.

Objectives

We aimed to synthesise evidence on attribute development, alongside an in-depth review of included attributes and methodological challenges, to provide a resource for researchers undertaking future studies in cancer screening.

Methods

A systematic review was conducted to identify discrete choice experiments estimating preferences towards cancer screening, dated between 1990 and December 2020. Data were synthesised narratively. In-depth analysis of attributes led to classification into four categories: test specific, service delivery, outcomes and monetary. Attribute significance and relative importance were also analysed. The International Society for Pharmacoeconomics and Outcomes Research conjoint analysis checklist was used to assess the quality of reporting.

Results

Forty-nine studies were included at full text. They covered a range of cancer sites: over half (26/49) examined colorectal screening. Most studies elicited general public preferences (34/49). In total, 280 attributes were included, 90% (252/280) of which were significant. Overall, test sensitivity and mortality reduction were most frequently found to be the most important to respondents.

Conclusions

Improvements in reporting the identification, selection and construction of attributes used within cancer screening discrete choice experiments are needed. This review also highlights the importance of considering the complexity of choice tasks when considering risk information or compound attributes. Patient and public involvement and stakeholder engagement are recommended to optimise understanding of unavoidably complex choice tasks throughout the design process. To ensure quality and maximise comparability across studies, further research is needed to develop a risk-of-bias measure for discrete choice experiments.

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Fig 1:

adapted from Moher, et al.

Fig. 2
Fig. 3

Change history

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Acknowledgements

The authors thank Jenny Lowe, University of Exeter for helping to run the database searches that formed part of this review. We thank Nia Morrish for assisting in the initial screening of the search results.

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Authors and Affiliations

  1. College of Medicine and Health, University of Exeter, South Cloisters, St Luke’s Campus, Heavitree, Exeter, EX1 2LU, UK

    Rebekah Hall, Antonieta Medina-Lara, Willie Hamilton & Anne E. Spencer

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  1. Rebekah Hall
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  2. Antonieta Medina-Lara
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Correspondence to Rebekah Hall.

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This research arises from the CanTest Collaborative, which is funded by Cancer Research UK (reference number: C8640/A23385), of which Rebekah Hall is a funded PhD student, Willie Hamilton is a director and Anne E. Spencer is a senior faculty member.

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The authors have no conflicts of interest that are directly relevant to the content of this article.

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All authors contributed to the study conception and design. Searches, screening and data abstraction were performed by RH and AM-L. The first draft of the manuscript was written by RH and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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The original Online version of this article was revised: The data points In figure 2 were missed and published.

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Hall, R., Medina-Lara, A., Hamilton, W. et al. Attributes Used for Cancer Screening Discrete Choice Experiments: A Systematic Review. Patient 15, 269–285 (2022). https://doi.org/10.1007/s40271-021-00559-3

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