Psychometric Validation of the Heart Failure Caregiver Questionnaire (HF-CQ®)

Abstract

Background

The Heart Failure Caregiver Questionnaire (HF-CQ®) was developed to assess subjective outcomes of heart failure caregivers. The HF-CQ® comprises 21 questions on three domains, namely physical, emotional/psychological and lifestyle. The objective of this study was to evaluate the psychometric properties of the HF-CQ®.

Methods

Patients (n = 150) with heart failure and their primary caregivers (n = 150) were recruited from 11 sites in USA. Caregivers completed the HF-CQ® and additional questionnaires, namely Caregiver Reaction Assessment, Work Productivity and Activity Impairment questionnaire, EuroQol-5 domain, and the Hospital Anxiety and Depression Scale. Patient-completed Global Impression of Severity, construct validity, concurrent validity, reliability and responsiveness of the HF-CQ® were also assessed.

Results

In the physical and lifestyle domains, all items showed acceptable validity. No high correlations between HF-CQ® scores and other caregiver-completed instruments, including the Hospital Anxiety and Depression Scale, Work Productivity and Activity Impairment questionnaire, EuroQol-5 domain or Caregiver Reaction Assessment, were reported. The intra-class correlation coefficient exceeded the threshold for reliability (>0.7) across the physical well-being (0.785), emotional/psychological (0.797), lifestyle (0.787) and total scores (0.850), indicating acceptable reliability. Internal consistency results using Cronbach’s alpha showed the total aggregate score of 0.942 to be reliable. In the responsiveness analyses, each of the three scales and the total score showed responsiveness to changes defined by the Caregiver Global Impression of Severity. The overall caregiver burden score increased with increased severity of illness in the cared-for patients.

Conclusions

The study provides initial evidence for the acceptable validity of the HF-CQ® as an instrument to measure heart failure caregiver burden.

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Acknowledgements

The authors are grateful to Pelle Stolt from MagliaRotta for providing writing support for this article. All authors contributed to the study design, the protocol and the analysis and intrepretation of data. Nicola Bonner, Bryan Bennet, Laura Grant performed the statistical analysis.

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Corresponding author

Correspondence to Frederico Calado.

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Funding

This study was funded by Novartis Pharma AG, Basel, Switzerland.

Conflict of interest

Nicola Bonner, Bryan Bennett and Laura Grant work for Adelphi Values and were contracted by Novartis Pharma AG to design and run the validation study and conduct the analyses. Frederico Calado and Celine Deschaseaux are employees of Novartis Pharma AG. Anna Stromberg, Misook Chung, Marie-Louise Luttik, Tiny Jaarsma and Eldring Lewis received consulting fees as advisors on the study scientific design. There are no additional conflicts of interest.

Ethics approval

This study was reviewed and approved by the Copernicus Group Institutional Review Board (Approval Number ADE1-13-493).

Consent to participate

Informed consent was obtained from all individual participants included in the study.

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Strömberg, A., Bonner, N., Grant, L. et al. Psychometric Validation of the Heart Failure Caregiver Questionnaire (HF-CQ®). Patient 10, 579–592 (2017). https://doi.org/10.1007/s40271-017-0228-x

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Keywords

  • Heart Failure Patient
  • Informal Caregiver
  • Caregiver Burden
  • Standardise Effect Size
  • Caregiver Reaction Assessment