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Managing nocardiosis: a review and case series of its treatment with trimethoprim–sulfamethoxazole

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Abstract

Nocardiosis is clinically challenging because of its variable clinicopathologic features, the inherent difficulties in cultivating the pathogen, the lack of exact treatment regimen, and its high propensity to recur. We report a case series of nocardiosis with diverse clinical presentations (primary pulmonary, primary cutaneous, and disseminated) and successful treatment with trimethoprim–sulfamethoxazole (TMP–SMX). We briefly review the cases to assess the efficacy of treatment with TMP–SMX. The optimal therapy for nocardiosis has yet to be established. Our clinical experience, together with the clinical evidence in the literature, suggests that TMP–SMX should be considered as the therapeutic drug of choice for treating nocardiosis.

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Acknowledgements

The authors acknowledge their tremendous obligation to the laboratory staff of the Grande International Hospital.

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PK made the diagnosis, designed the manuscript, reviewed the literature and prepared the article for submission. DSS helped with the literature review, provided the concept for the research paper, and critically reviewed the manuscript. Both authors read and approved the final manuscript.

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Correspondence to Priyatam Khadka.

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Priyatam Khadka and Dibya Singh Shah have no conflicts of interest that are directly relevant to the content of this article.

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Khadka, P., Shah, D.S. Managing nocardiosis: a review and case series of its treatment with trimethoprim–sulfamethoxazole. Drugs Ther Perspect 35, 563–570 (2019). https://doi.org/10.1007/s40267-019-00661-5

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