Corticosteroid pulse therapy-associated aseptic humeral and femoral head necrosis: a case report

  • Dalia M. AminEmail author
Short Communication


Corticosteroid pulse therapy is the administration of suprapharmacologic doses of corticosteroids in an intermittent manner to enhance their therapeutic effects and reduce their adverse effects. This report describes the complications of pulse therapy and long-term use of corticosteroids in a male patient aged 37 years who has had multiple sclerosis since 2003. The patient was diagnosed with aseptic necrosis of the humerus and femur heads after a course of corticosteroid pulse therapy in May 2015. This case is interesting not only because the patient developed aseptic necrosis of the femoral, as well as humeral, heads, but also because the patient received stem-cell therapy after an intensive course of corticosteroids as a recommended up-to-date therapy to treat this complication of pulse therapy.



The author gratefully acknowledges the support and help provided by the staff of the neurology and radiology departments of Zagazig University Hospital.

Compliance with ethical standards

Conflict of interest

Dalia M. Amin declares no conflict of interests in relation to this article.


No financial support was received for this case report.

Ethical considerations

This case report was approved by the local ethics committee of the Faculty of Medicine, Zagazig University Hospital, Zagazig, Egypt.

Informed consent

The patient gave informed written consent regarding the publication of the case report.


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Forensic Medicine and Clinical Toxicology Department, Faculty of MedicineZagazig UniversityZagazigEgypt

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