Drugs & Therapy Perspectives

, Volume 34, Issue 5, pp 222–222 | Cite as

First reports of adverse drug reactions

Drug Reactions and Interactions
Table 1 contains an overview of first published case reports of adverse drug reactions identified in the international literature in recent weeks by Reactions Weekly, the Adis drug safety newsletter. Reactions Weekly provides summaries of adverse drug reaction news sourced from journals, scientific meetings, media releases, regulatory agency websites, and bulletins from the National Centers that participate in the WHO International Drug Monitoring Programme.
Table 1

First published reports of adverse drug reactions recently identified by Reactions Weekly

Drug and adverse reaction


Apixaban: delayed hypersensitivity reaction

Albalbissi A, Balagoni H, Treece J, et al. Cutaneous adverse drug reaction due to apixaban [abstract no. P033]. Ann Allergy Asthma Immunol. 2017;119(5 Suppl 1):S27. doi:10.1016/j.anai.2017.08.102

Bendamustine: acute liver failure and encephalopathy (serious)

Shah P, Sasson A, Iswara K, et al. A case report of acute liver failure due to use of a new alkylating agent bendamustine [abstract no Su1389]. Gastroenterology. 2017;152(5 Suppl 1):S1120. doi:10.1016/s0016-5085(17)33773-3

Botulinum toxin A: gastric necrosis and haemorrhagic gastritis leading to septic shock (serious)

Nimeri A, Zaman MB, Maasher A, et al. Endoscopic intra-gastric botulinum toxin injection for obesity leading to total gastrectomy and Roux en Y esophago-jejunostomy [abstract no. A5097]. Surg Obes Relat Dis. 2016;12(7 Suppl 1):S116. doi:10.1016/j.soard.2016.08.181

Cefalexin: acute pancreatitis (serious)

Alim H, Moustafa A, Youssef E, et al. Acute pancreatitis due to cephalexin: a case report and review of literature [abstract no. 2823]. Am J Gastroenterol. 2017;112(Suppl 1):S1518. doi:10.1038/ajg.2017.342

Ceftaroline fosamil: bronchospasm (serious)

Jansen JW, Moenster RP. Rate and incidence of adverse reactions associated with ceftaroline exposure: importance of cutaneous manifestations. Ann Pharmacother. 2018;52(3):235–9. doi:10.1177/1060028017735629

Chandraprabha vati + divya stri rasayan vati: pemphigus vulgaris (serious)

Gari M, Majhee L, Kumari K. Herbal drug-induced adverse drug reaction: a case report. Asian J Pharmaceut Clin Res. 2018;11(2):9–11. doi:10.22159/ajpcr.2018.v11i2.22208

Itraconazole + vindesine: syndrome of inappropriate antidiuretic hormone secretion (serious)

Zhou H, Li L, Zhou Y, et al. Syndrome of inappropriate antidiuretic hormone secretion from concomitant use of itraconazole and vindesine. J Clin Pharm Ther .2018;43(1):137–40. doi:10.1111/jcpt.12598

Nivolumab: renal tubular acidosis (serious)

El Bitar S, Weerasinghe C, El-Charabaty E, et al. Renal tubular acidosis an adverse effect of PD-1 inhibitor immunotherapy. Case Rep Oncol Med. 2018;2018. doi:10.1155/2018/8408015

Pemetrexed: cardiomyopathy (serious)

Oyakawa T, Iida K, Kusuhara M, et al. Chemotherapy-induced cardiomyopathy caused by pemetrexed. Invest New Drugs. 2018;36(1):147–50. doi:10.1007/s10637-017-0485-5

Sitagliptin: pemphigus vulgaris (serious)

Okauchi Y, Tomoda Y, Deguchi A, et al. Pemphigus vulgaris developing after 6-month treatment with a dipeptidyl peptidase-4 inhibitor: a case report. J Dermatol. 2018;45(2):e39–e40. doi:10.1111/1346-8138.14076

Tramadol: acute kidney failure secondary to granulomatous interstitial nephritis (serious)

Borrego Utiel FJ, Luque Barona R, Perez del Barrio P, et al. Acute kidney injury due to granulomatous interstitial nephritis induced by tramadol administration [in Spanish]. Nefrologia. 2018;38(2):227–8. doi:10.1016/j.nefro.2017.05.005

An event is serious (US FDA MedWatch definition) when the patient outcome is death, life threatening, hospitalization, disability, congenital anomaly or requires intervention to prevent permanent impairment or damage

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