Cellulite: no clear evidence that any type of treatment is effective


The treatment of cellulite, a major cosmetic concern for many women, remains challenging. Although a number of studies have investigated the effects of a wide range of products/procedures on cellulite-related endpoints, most of these studies have important methodological flaws. At present, there is no clear clinical evidence that any evaluated treatments have good efficacy in reducing cellulite, with the most promising results shown with acoustic wave therapy.

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  1. 1.

    Luebberding S, Krueger N, Sadick NS. Cellulite: an evidence-based review. Am J Clin Dermatol. 2015;16(4):243–56.

    Article  PubMed  Google Scholar 

  2. 2.

    Emanuele E. Cellulite: advances in treatment: facts and controversies. Clin Dermatol. 2013;31(6):725–30.

    Article  PubMed  Google Scholar 

  3. 3.

    Hexsel DM, Dal’forno T, Hexsel CL. A validated photonumeric cellulite severity scale. J Eur Acad Dermatol Venereol. 2009;23(5):523–8.

    CAS  Article  PubMed  Google Scholar 

  4. 4.

    Turati F, Pelucchi C, Marzatico F, et al. Efficacy of cosmetic products in cellulite reduction: systematic review and meta-analysis. J Eur Acad Dermatol Venereol. 2014;28(1):1–15.

    CAS  Article  PubMed  Google Scholar 

  5. 5.

    Adatto M, Adatto-Neilson R, Servant J-J, et al. Controlled, randomized study evaluating the effects of treating cellulite with AWT/EPAT. J Cosmet Laser Ther. 2010;12(4):176–82.

    Article  PubMed  Google Scholar 

  6. 6.

    Russe-Wilflingseder K, Russe-Wilfingsleder K, Russe E, et al. Placebo controlled, prospectively randomized, double-blinded study for the investigation of the effectiveness and safety of the acoustic wave therapy (AWT®) for cellulite treatment. J Cosmet Laser Ther. 2013;15(3):155–62.

    Article  PubMed  Google Scholar 

  7. 7.

    Knobloch K, Joest B, Krämer R, et al. Cellulite and focused extracorporeal shockwave therapy for non-invasive body contouring: a randomized trial. Dermatol Ther. 2013;3(2):143–55.

    Article  Google Scholar 

  8. 8.

    Bousquet-Rouaud R, Bazan M, Chaintreuil J, et al. High-frequency ultrasound evaluation of cellulite treated with the 1064 nm Nd:YAG laser. J Cosmet Laser Ther. 2009;11(1):34–44.

    Article  PubMed  Google Scholar 

  9. 9.

    Truitt A, Elkeeb L, Ortiz A, et al. Evaluation of a long pulsed 1064-nm Nd:YAG laser for improvement in appearance of cellulite. J Cosmet Laser Ther. 2012;14(3):139–44.

    Article  PubMed  Google Scholar 

  10. 10.

    Jackson RF, Roche GC, Shanks SC. A double-blind, placebo-controlled randomized trial evaluating the ability of low-level laser therapy to improve the appearance of cellulite. Lasers Surg Med. 2013;45(3):141–7.

    Article  PubMed  Google Scholar 

  11. 11.

    Smalls LK, Hicks M, Passeretti D, et al. Effect of weight loss on cellulite: gynoid lypodystrophy. Plast Reconstr Surg. 2006;118(2):510–6.

    CAS  Article  PubMed  Google Scholar 

  12. 12.

    Lis-Balchin M. Parallel placebo-controlled clinical study of a mixture of herbs sold as a remedy for cellulite. Phytother Res. 1999;13(7):627–9.

    CAS  Article  PubMed  Google Scholar 

  13. 13.

    Distante F, Bacci PA, Carrera M. Efficacy of a multifunctional plant complex in the treatment of the so-called “cellulite”: clinical and instrumental evaluation. Int J Cosmet Sci. 2006;28(3):191–206.

    CAS  Article  PubMed  Google Scholar 

  14. 14.

    Kligman A, Pagnoni A, Stoudemayer T. Topical retinol improves cellulite. J Dermatol Treat. 1999;10(2):119–25.

    CAS  Article  Google Scholar 

  15. 15.

    Lesser T, Ritvo E, Moy LS. Modification of subcutaneous adipose tissue by a methylxanthine formulation: a double-blind controlled study. Dermatol Surg. 1999;25(6):455–62.

    CAS  Article  PubMed  Google Scholar 

  16. 16.

    Al-Bader T, Byrne A, Gillbro J, et al. Effect of cosmetic ingredients as anticellulite agents: synergistic action of actives with in vitro and in vivo efficacy. J Cosmet Dermatol. 2012;11(1):17–26.

    Article  PubMed  Google Scholar 

  17. 17.

    Bertin C, Zunino H, Pittet JC, et al. A double-blind evaluation of the activity of an anti-cellulite product containing retinol, caffeine, and ruscogenine by a combination of several non-invasive methods. J Cosmet Sci. 2001;52(4):199–210.

    CAS  PubMed  Google Scholar 

  18. 18.

    Collis N, Elliot LA, Sharpe C, et al. Cellulite treatment: a myth or reality: a prospective randomized, controlled trial of two therapies, endermologie and aminophylline cream. Plast Reconstr Surg. 1999;104(4):1110–7.

    CAS  Article  PubMed  Google Scholar 

  19. 19.

    Dupont E, Journet M, Oula M-L, et al. An integral topical gel for cellulite reduction: results from a double-blind, randomized, placebo-controlled evaluation of efficacy. Clin Cosmet Investig Dermatol. 2014;7:73–88.

    PubMed Central  PubMed  Google Scholar 

  20. 20.

    Epstein E, Young VL, Schorr M, et al. Prospective and randomized determination of the efficacy of topical lipolytic agents. Aesthetic Surg J. 1997;17(5):304–7.

    CAS  Article  Google Scholar 

  21. 21.

    Mlosek RK, Dębowska RM, Lewandowski M, et al. Imaging of the skin and subcutaneous tissue using classical and high-frequency ultrasonographies in anti-cellulite therapy. Skin Res Technol. 2011;17(4):461–8.

    Article  PubMed  Google Scholar 

  22. 22.

    Roure R, Oddos T, Rossi A, et al. Evaluation of the efficacy of a topical cosmetic slimming product combining tetrahydroxypropyl ethylenediamine, caffeine, carnitine, forskolin and retinol, in vitro, ex vivo and in vivo studies. Int J Cosmet Sci. 2011;33(6):519–26.

    CAS  Article  PubMed  Google Scholar 

  23. 23.

    Sasaki GH, Oberg K, Tucker B, et al. The effectiveness and safety of topical PhotoActif phosphatidylcholine-based anti-cellulite gel and LED (red and near-infrared) light on Grade II-III thigh cellulite: a randomized, double-blinded study. J Cosmet Laser Ther. 2007;9(2):87–96.

    Article  PubMed  Google Scholar 

  24. 24.

    Sparavigna A, Guglielmini G, Togni S, et al. Evaluation of anti-cellulite efficacy: a topical cosmetic treatment for cellulite blemishes: a multifunctional formulation. J Cosmet Sci. 2011;62(3):305–16.

    CAS  PubMed  Google Scholar 

  25. 25.

    Vogelgesang B, Bonnet I, Godard N, et al. In vitro and in vivo efficacy of sulfo-carrabiose, a sugar-based cosmetic ingredient with anti-cellulite properties. Int J Cosmet Sci. 2011;33(2):120–5.

    CAS  Article  PubMed  Google Scholar 

  26. 26.

    Bagatin E, Miot HA, Soares JLM, et al. Long-wave infrared radiation reflected by compression stockings in the treatment of cellulite: a clinical double-blind, randomized and controlled study. Int J Cosmet Sci. 2013;35(5):502–9.

    CAS  Article  PubMed  Google Scholar 

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This article was adapted from the American Journal of Clinical Dermatology 2015;16(4):243–56 [1] by salaried employees of Adis/Springer, and was not supported by any external funding.

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Cellulite: no clear evidence that any type of treatment is effective. Drugs Ther Perspect 31, 437–440 (2015). https://doi.org/10.1007/s40267-015-0246-5

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