Buprenorphine/naloxone sublingual tablet (Zubsolv®): a guide to its use in the maintenance treatment of opioid dependence in the USA


Zubsolv® is a new sublingual formulation of buprenorphine/naloxone that is indicated for the maintenance treatment of opioid dependence in the USA. The effectiveness and tolerability of buprenorphine/naloxone in this indication is well established. Relative to other sublingual formulations of buprenorphine/naloxone, Zubsolv® dissolves more rapidly, has greater bioavailability, tastes better, and may be preferred by many patients.

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The manuscript was reviewed by: S. Helm, Pacific Coast Pain Management Center, Laguna Hills, CA, USA; M. Hillhouse, UCLA Integrated Substance Abuse Programs, Los Angeles, CA, USA, C.M. Renzelli, Gateway Rehabilitation Center, Moon Township, PA, USA.


The preparation of this review was not supported by any external funding. During the peer review process, the manufacturer of the agent under review was offered an opportunity to comment on the article. Changes resulting from comments received were made by the author on the basis of scientific and editorial merit.

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Correspondence to Katherine A. Lyseng-Williamson.

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Lyseng-Williamson, K.A. Buprenorphine/naloxone sublingual tablet (Zubsolv®): a guide to its use in the maintenance treatment of opioid dependence in the USA. Drugs Ther Perspect 29, 336–341 (2013). https://doi.org/10.1007/s40267-013-0079-z

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  • Naloxone
  • Buprenorphine
  • Atazanavir
  • Opioid Dependence
  • Opioid Withdrawal