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Interprofessional Interventions Involving Pharmacists and Targeting the Medicines Management Process Provided to Older People Residing in Nursing Homes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

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Abstract

Background

Nursing home residents are often prescribed multiple medications, which increases their susceptibility to drug-related problems. The medicines management process involves multiple stages, for example, assessing, prescribing, dispensing, delivering and storing, administering, reviewing and monitoring. The medicine management process aims to optimise medicine use and associated patient outcomes. Interprofessional interventions of healthcare professionals from different disciplines in many clinical settings, including the nursing home setting, have shown success in improving patients’ clinical outcomes. However, reporting of the pharmacist’s role and the impact of these interventions has been unclear.

Objectives

We aimed to systematically identify and describe interprofessional interventions involving pharmacists that target the medicine management process in nursing homes by (a) describing interprofessional interventions and the role of pharmacists within, (b) describing the impact of these interventions, (c) exploring which of the medicine management process stages were targeted and (d) identifying any reported theoretical underpinning.

Methods

EMBASE, MEDLINE, CINAHL, SCOPUS, PsycInfo, Cochrane library, Web of Science and clinical trial registers were searched from the inception date until August 2021. Randomised controlled trials reporting interprofessional interventions involving pharmacists, targeting at least one stage of the medicine management process and provided to nursing home residents with a mean age ≥ 65 years, were included. The search had no restriction on outcomes measured. Included randomised controlled trials were assessed for quality and risk of bias using the Jadad scale and Cochrane Collaboration tool, respectively. The overall certainty of outcomes was assessed using GRADEpro. If present, details about theoretical underpinning were extracted using the theory coding scheme. Fixed and random-effects models were used to calculate the pooled effect estimates to compare outcomes between intervention and control groups, where feasible, or a narrative description was reported.

Results

Eighteen manuscripts describing interprofessional interventions involving pharmacists were identified: medication review (n = 14), education (n = 3) and medication simplification (n = 1) based interventions. The pharmacists’ most frequent role was the provision of medicine-related recommendations, and they worked mostly with general practitioners and nurses. Residents/family members contributed in 44% of included interventions. A meta-analysis identified that interventions were significantly associated with significant improvements in prescribing appropriateness (standard mean difference − 0.20; 95% confidence interval − 0.33 to − 0.77; I2 = 27%) but not with hospitalisation and mortality. None of the included studies reported a theoretical underpinning to intervention development.

Conclusions

This systematic review provides a detailed description of the impact of interprofessional practice, involving pharmacists, which targets at least one stage of the medicine management process in the nursing home setting. The findings suggest that future research should prioritise improving prescribing inappropriateness rather than the number of long-term medications prescribed. It remains unknown if interventions are designed using theory and, therefore, it is not clear whether theory-derived interventions are more effective than those without a theoretical element.

Clinical Trial Registration

The protocol was published in the International Prospective Register of Systematic Reviews (PROSPERO) [Ref: CRD42020181744].

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References

  1. World Atlas. Countries with the largest aging population 2017. Available from: https://www.worldatlas.com/articles/countries-with-the-largest-aging-population-in-the-world.html. Accessed 16 Sep 2022.

  2. Canadian Institute for Health Information. Continuing care reporting system: data users guide. 2020. Available from: https://secure.cihi.ca/free_products/CCRS-external-data-users-guide-2017-2018-en-web.pdf. Accessed 16 Sep 2022.

  3. Rolland Y, Abellan Van Kan G, Hermabessiere S, Gérard S, Guyonnet-Gillette S, Vellas B. Descriptive study of nursing home residents from the REHPA network. J Nutr Health Aging. 2009;13(8):679.

    Article  CAS  Google Scholar 

  4. Mahlknecht A, Nestler N, Bauer U, Schüßler N, Schuler J, Scharer S, et al. Effect of training and structured medication review on medication appropriateness in nursing home residents and on cooperation between health care professionals: the InTherAKT study protocol. BMC Geriatric. 2017;17(1):24.

    Article  Google Scholar 

  5. Ivanova I, Wauters M, Vander Stichele R, Christiaens T, De Wolf J, Dilles T, Elseviers M. Medication use in a cohort of newly admitted nursing home residents (Ageing@ NH) in relation to evolving physical and mental health. Arch Gerontol Geriatric. 2018;75:202–8.

  6. Hill-Taylor B, Walsh KA, Stewart S, Hayden J, Byrne S, Sketris IS. Effectiveness of the STOPP/START (Screening Tool of Older Persons' potentially inappropriate Prescriptions/Screening Tool to Alert doctors to the Right Treatment) criteria: systematic review and meta‐analysis of randomized controlled studies. J Clin Pharm Ther. 2016;41(2):158–69.

  7. Theou O, Sluggett JK, Bell JS, Lalic S, Cooper T, Robson L, Morley JE, Rockwood K, Visvanathan R. Frailty, hospitalization, and mortality in residential aged care. J Gerontol Ser A. 2018;73(8):1090–6.

    Article  Google Scholar 

  8. National Institute for health and Care Excellence (NICE). Medicines optimisation: the safe and effective use of medicines to enable the best possible outcomes. Available from: https://www.nice.org.uk/guidance/ng5/chapter/introduction. Accessed 16 Sep 2022.

  9. Health Information and Quality Authority. Medicines management guidance policies and procedures for medicines management in Ireland. p. 9. https://www.hiqa.ie/sites/default/files/2017-01/Medicines-Management-Guidance.pdf

  10. Hicks RW, Sikirica V, Nelson W, Schein JR, Cousins DD. Medication errors involving patient-controlled analgesia. American J Health Syst Pharm. 2008;65(5):429–40.

  11. Davidsson M, Vibe OE, Ruths S, Blix HS. A multidisciplinary approach to improve drug therapy in nursing homes. J Multidiscip Healthc. 2011;4:9–13.

    PubMed  PubMed Central  Google Scholar 

  12. Mertens F, Debrulle Z, Lindskog E, Deliens L, Deveugele M, Pype P. Healthcare professionals’ experiences of inter-professional collaboration during patient’s transfers between care settings in palliative care: A focus group study. Palliat Med. 2021;35(2):355–66.

  13. Ozavci G, Bucknall T, Woodward-Kron R, Hughes C, Jorm C, Joseph K, Manias E. A systematic review of older patients’ experiences and perceptions of communication about managing medication across transitions of care. Res Soc Adm Pharm. 2021;17(2):273–91.

  14. Hsu J, Price M, Huang J, Brand R, Fung V, Hui R, Fireman B, Newhouse JP, Selby JV. Unintended consequences of caps on Medicare drug benefits. New Engl J Med. 2006;354(22):2349–59.

  15. Scarsi KK, Fotis MA, Noskin GA. Pharmacist participation in medical rounds reduces medication errors. Am J Health Syst Pharm. 2002;59(21):2089–92.

    Article  Google Scholar 

  16. Hasan Ibrahim AS, Barry HE, Hughes CM. A systematic review of general practice-based pharmacists’ services to optimize medicines management in older people with multimorbidity and polypharmacy. Fam Pract. 2021;38(4):509–23.

    Article  Google Scholar 

  17. Rahayu SA, Widianto S, Defi IR, Abdulah R. Role of pharmacists in the interprofessional care team for patients with chronic diseases. J Multidiscip Healthc. 2021;14:1701.

    Article  Google Scholar 

  18. Sadeq AA, Shamseddine JM, Babiker ZO, Nsutebu EF, Moukarzel MB, Conway BR, Hasan SS, Conlon-Bingham GM, Aldeyab MA. Impact of Multidisciplinary Team Escalating Approach on Antibiotic Stewardship in the United Arab Emirates. Antibiotics. 2021;10(11):1289.

  19. Spinewine A, Evrard P, Hughes C. Interventions to optimize medication use in nursing homes: a narrative review. European Geriatric Medicine. 2021;12(3):551–67.

  20. Verrue CL, Petrovic M, Mehuys E, Remon JP, Vander Stichele R. Pharmacists’ interventions for optimization of medication use in nursing homes. Drugs Aging. 2009;26(1):37–49.

    Article  Google Scholar 

  21. Craig P, Dieppe P, Macintyre S, Michie S, Nazareth I, Petticrew M. Developing and evaluating complex interventions: the new Medical Research Council guidance. Bmj. 2008;337.

  22. UK Research and Innovation. Medical Research Council guidance for applicants. 2022. Available from: https://www.ukri.org/publications/mrc-guidance-for-applicants/. Accessed 16 Sept 2022.

  23. Rimer BK, Glanz K. Theory at a glance: a guide for health promotion practice. US Department of Health and Human Services, National Institutes of Health, National Cancer Institute; 2005.

  24. Michie S, Prestwich A. Are interventions theory-based? Development of a theory coding scheme. Health Psychol. 2010;29(1):1.

  25. Page MJ, Moher D. Evaluations of the uptake and impact of the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) Statement and extensions: a scoping review. Syst Rev. 2017;6(1):1–4.

  26. Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA, editors. Cochrane handbook for systematic reviews of interventions. Wiley; 2019.

  27. Lefebvre C, Glanville J, Briscoe S, Featherstone R, Littlewood A, Marshall C, Metzendorf M-I, Noel-Storr A, Paynter R, Rader T, Thomas J, Wieland LS. Technical Supplement to Chapter 4: Searching for and selecting studies. In: Higgins JPT, Thomas J, Chandler J, Cumpston MS, Li T, Page MJ, Welch VA editors. Cochrane handbook for systematic reviews of interventions version 6.3 (updated February 2022). Cochrane, 2022. Available from: www.training.cochrane.org/handbook.

  28. Mowatt G, Grimshaw JM, Davis DA, Mazmanian PE. Getting evidence into practice: the work of the Cochrane Effective Practice and Organization of Care Group (EPOC). J Contin Educ Health Prof. 2001;21(1):55–60.

  29. Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, McQuay HJ. Assessing the quality of reports of randomized clinical trials: is blinding necessary?. Control Clin Trials. 1996;17(1):1-2.

    Article  CAS  Google Scholar 

  30. Higgins JP, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD, Savović J, Schulz KF, Weeks L, Sterne JA. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. Bmj. 2011;343.

  31. GRADEpro GDT: GRADEpro Guideline Development Tool [Software]. McMaster University and Evidence Prime, 2022. Available from gradepro.org.

  32. Crotty M, Halbert J, Rowett D, Giles L, Birks R, Williams H, Whitehead C. An outreach geriatric medication advisory service in residential aged care: a randomised controlled trial of case conferencing. Age Ageing. 2004;33(6):612–7.

    Article  Google Scholar 

  33. Crotty M, Whitehead C, Rowett D, Halbert J, Weller D, Finucane P, Esterman A. An outreach intervention to implement evidence based practice in residential care: a randomized controlled trial [ISRCTN67855475]. BMC Health Serv Res. 2004;4(1):1–6.

  34. Frankenthal D, Lerman Y, Kalendaryev E, Lerman Y. Intervention with the screening tool of older persons potentially inappropriate prescriptions/screening tool to alert doctors to right treatment criteria in elderly residents of a chronic geriatric facility: a randomized clinical trial. J Am Geriatr Soc. 2014;62(9):1658–65.

    Article  Google Scholar 

  35. Kennedy CC, Ioannidis G, Thabane L, Adachi JD, Marr S, Giangregorio LM, Morin SN, Crilly RG, Josse RG, Lohfeld L, Pickard LE. Successful knowledge translation intervention in long-term care: final results from the vitamin D and osteoporosis study (ViDOS) pilot cluster randomized controlled trial. Trials. 2015;16(1):1–1.

    Article  Google Scholar 

  36. Lapane KL, Hughes CM, Daiello LA, Cameron KA, Feinberg J. Effect of a pharmacist‐led multicomponent intervention focusing on the medication monitoring phase to prevent potential adverse drug events in nursing homes. J Am Geriatr Soc. 2011;59(7):1238–45.

    Article  Google Scholar 

  37. Patterson SM, Hughes CM, Crealey G, Cardwell C, Lapane KL. An evaluation of an adapted US model of pharmaceutical care to improve psychoactive prescribing for nursing home residents in Northern Ireland (Fleetwood Northern Ireland study). J Am Geriatr Soc. 2010;58(1):44–53.

    Article  Google Scholar 

  38. Roberts MS, Stokes JA, King MA, Lynne TA, Purdie DM, Glasziou PP, Wilson DA, McCarthy ST, Brooks GE, De Looze FJ, Del Mar CB. Outcomes of a randomized controlled trial of a clinical pharmacy intervention in 52 nursing homes. Br J Clin Pharmacol. 2001;51(3):257–65.

    Article  CAS  Google Scholar 

  39. Schmidt I, B. Claesson C, Westerholm B, Nilsson LG, Svarstad BL. The impact of regular multidisciplinary team interventions on psychotropic prescribing in Swedish nursing homes. J Am Geriatr Soc. 1998;46(1):77–82.

    Article  CAS  Google Scholar 

  40. van der Spek K, Koopmans RT, Smalbrugge M, Nelissen-Vrancken MH, Wetzels RB, Smeets CH, De Vries E, Teerenstra S, Zuidema SU, Gerritsen DL. The effect of biannual medication reviews on the appropriateness of psychotropic drug use for neuropsychiatric symptoms in patients with dementia: a randomised controlled trial. Age Ageing. 2018;47(3):430–7.

    Article  Google Scholar 

  41. Wouters H, Scheper J, Koning H, Brouwer C, Twisk JW, van der Meer H, Boersma F, Zuidema SU, Taxis K. Discontinuing inappropriate medication use in nursing home residents: a cluster randomized controlled trial. Ann Inter Med. 2017;167(9):609–17.

    Google Scholar 

  42. Zermansky AG, Alldred DP, Petty DR, Raynor DK, Freemantle N, Eastaugh J, Bowie P. Clinical medication review by a pharmacist of elderly people living in care homes—randomised controlled trial. Age Ageing. 2006;35(6):586–91.

    Article  Google Scholar 

  43. Desborough JA, Clark A, Houghton J, Sach T, Shaw V, Kirthisingha V, Holland RC, Wright DJ. Clinical and cost effectiveness of a multi-professional medication reviews in care homes (CAREMED). Int J Pharm Pract. 2020;28(6):626-34.

  44. Kua CH, Yeo CY, Tan PC, Char CW, Tan CW, Mak V, Leong IY, Lee SW. Association of deprescribing with reduction in mortality and hospitalization: a pragmatic stepped-wedge cluster-randomized controlled trial. J Am Med Dir Assoc. 2021;22(1):82-9.

  45. Sluggett JK, Chen EY, Ilomäki J, Corlis M, Van Emden J, Hogan M, Caporale T, Keen C, Hopkins R, Ooi CE, Hilmer SN. Reducing the burden of complex medication regimens: SImplification of Medications Prescribed to Long-tErm care Residents (SIMPLER) cluster randomized controlled trial. J Am Med Dir Assoc. 2020;21(8):1114–20.

    Article  Google Scholar 

  46. Smeets CH, Smalbrugge M, Koopmans RT, Nelissen-Vrancken MH, Van Der Spek K, Teerenstra S, Gerritsen DL, Zuidema SU. Can the PROPER intervention reduce psychotropic drug prescription in nursing home residents with dementia? Results of a cluster-randomized controlled trial. Int Psychogeriatr. 2021;33(6):577–86.

  47. Strauven G, Anrys P, Vandael E, Henrard S, De Lepeleire J, Spinewine A, Foulon V. Cluster-controlled trial of an intervention to improve prescribing in nursing homes study. J Am Med Dir Assoc. 2019;20(11):1404–11.

  48. Tadrous M, Fung K, Desveaux L, Gomes T, Taljaard M, Grimshaw JM, Bell CM, Ivers NM. Effect of academic detailing on promoting appropriate prescribing of antipsychotic medication in nursing homes: a cluster randomized clinical trial. JAMA Netw Open. 2020;3(5):e205724-.

  49. Cateau D, Ballabeni P, Niquille A. Effects of an interprofessional Quality Circle-Deprescribing Module (QC-DeMo) in Swiss nursing homes: a randomised controlled trial. BMC Geriatr. 2021;21(1):1–1.

    Article  Google Scholar 

  50. Sluggett JK, Hopkins RE, Chen EY, Ilomäki J, Corlis M, Van Emden J, Hogan M, Caporale T, Ooi CE, Hilmer SN, Bell JS. Impact of medication regimen simplification on medication administration times and health outcomes in residential aged care: 12 month follow up of the SIMPLER randomized controlled trial. J Clin Med. 2020;9(4):1053.

  51. Picton C, Wright H. Medicines optimisation: helping patients to make the most of medicines. Good practice guidance for healthcare professionals in England. Royal Pharmaceutical Society; 2013. Available from: https://www.rpharms.com/Portals/0/RPS%20document%20library/Open%20access/Policy/helping-patients-make-the-most-of-their-medicines.pdf. Accessed 16 Sept 2022.

  52. NICE. Medicines Optimisation: the safe and effective use of medicines to enable the best possible outcomes. National Institute for Health and Care Excellence; 2015. Available from: https://www.nice.org.uk/guidance/ng5. Accessed 16 Sept 2022.

  53. Storms H, Marquet K, Aertgeerts B, Claes N. Prevalence of inappropriate medication use in residential long-term care facilities for the elderly: a systematic review. Eur J Gen Pract. 2017;23(1):69–77.

  54. Freyche C, Zacarin A, Bagheri H. Potentially inappropriate psychotropic drug prescription in elderly people in West Occitanie area. Therapie. 2021.

  55. Baqir W, Hughes J, Jones T, Barrett S, Desai N, Copeland R, Campbell D, Laverty A. Impact of medication review, within a shared decision-making framework, on deprescribing in people living in care homes. Eur J Hosp Pharm. 2017;24(1):30-3.

  56. Westbrook JI, Woods A, Rob MI, Dunsmuir WT, Day RO. Association of interruptions with an increased risk and severity of medication administration errors. Arch Int Med. 2010;170(8):683–90.

  57. Young HM, Gray SL, McCormick WC, Sikma SK, Reinhard S, Johnson Trippett L, Christlieb C, Allen T. Types, prevalence, and potential clinical significance of medication administration errors in assisted living. J Am Geriatr Soc. 2008;56(7):1199–205.

  58. Cheung KC, Van Den Bemt PM, Bouvy ML, Wensing M, De Smet PA. Medication incidents related to automated dose dispensing in community pharmacies and hospitals-a reporting system study. PLoS One. 2014;9(7):e101686.

  59. Verrue CL, Mehuys E, Somers A, Van Maele G, Remon JP, Petrovic M. Medication administration in nursing homes: pharmacists' contribution to error prevention. J Am Med Direct Assoc. 2010;11(4):275–83.

  60. Prasanna SM, Cader TS, Sabalingam S, Shanika LG, Samaranayake NR. Are medications safely used by residents in elderly care homes?–A multi-centre observational study from Sri Lanka. PloS one. 2020;15(6):e0233486.

  61. Lee SW, Mak VS, Tang YW. Pharmacist services in nursing homes: a systematic review and meta‐analysis. Br J Clin Pharmacol. 2019;85(12):2668–88.

    Article  Google Scholar 

  62. Alldred DP, Kennedy MC, Hughes C, Chen TF, Miller P. Interventions to optimise prescribing for older people in care homes. Cochrane Database Syst Rev. 2016(2).

    PubMed  Google Scholar 

  63. Verrue CL, Petrovic M, Mehuys E, Remon JP, Vander Stichele R. Pharmacists’ interventions for optimization of medication use in nursing homes. Drugs Aging. 2009;26(1):37–49.

    Article  Google Scholar 

  64. Kolanowski AM, Litaker MS, Baumann MA. Theory-based intervention for dementia behaviors: A within-person analysis over time. Appl Nurs Res. 2002;15(2):87–96.

  65. Kolanowski AM, Litaker M, Buettner L. Efficacy of theory-based activities for behavioral symptoms of dementia. Nurs Res. 2005;54(4):219–28.

  66. Glasgow RE, Linnan LA. Evaluation of theory-based interventions. Health Behav. 2008:487.

  67. Cotter S, McKee M, Barber N. Pharmacists and prescribing: an unrecorded influence. Qual Health Care. 1993;2(2):75.

    Article  CAS  Google Scholar 

  68. Michie S, Van Stralen MM, West R. The behaviour change wheel: a new method for characterising and designing behaviour change interventions. Implement Sci. 2011;6(1):1–2.

  69. Holden RJ, Carayon P, Gurses AP, Hoonakker P, Hundt AS, Ozok AA, Rivera-Rodriguez AJ. SEIPS 2.0: a human factors framework for studying and improving the work of healthcare professionals and patients. Ergonomics. 2013;56(11):1669–86.

  70. Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, Shekelle P, Stewart LA. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015;4(1):1–9.

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Acknowledgements

The authors acknowledge Catriona Honohan (subject librarian in Trinity College Dublin) for helping with the development of the search terms and strategy; Greg Sheaf (subject librarian in Trinity College Dublin) in further assisting with finding full-text articles; Connie Brennan for helping in the title and abstract screening stage of the study; and Micheal Doody (Pharmacist in Median Healthcare pharmacy group) for supporting the concept and development of the study.

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Authors and Affiliations

  1. The School of Pharmacy and Pharmaceutical Sciences, Panoz Institute, Trinity College Dublin, The University of Dublin, Dublin 2, D02PN40, Ireland

    Asil Sadeq

  2. Trinity College Dublin, Dublin, Ireland

    Monica Strugaru, Maryam Almutairi, Cristin Ryan & Tamasine Grimes

  3. College of Pharmacy, QU Health, Qatar University, Doha, Qatar

    Derek Stewart

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Correspondence to Asil Sadeq.

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There was no funding source for this study.

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Asil Sadeq, Monica Strugaru, Maryam AlMutairi, Derek Stewart, Cristin Ryan and Tamasine Grimes have no conflicts of interest that are directly relevant to the content of this article.

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All data generated or analysed during this study are included in this published article (and its supplementary information files).

Author contributions

Study conception and design: AS, CR, TG. Screened references for eligibility: AS, MS, CR, TG, MA. Data extraction and assessment for quality: AS, MS, TG, MA. Drafted manuscript: AS. Critically reviewed and revised manuscript and approved final version: AS, CR, TG, DS, MS, MA. All authors have read and approved the final version of the manuscript and agree to be accountable for the work.

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Sadeq, A., Strugaru, M., Almutairi, M. et al. Interprofessional Interventions Involving Pharmacists and Targeting the Medicines Management Process Provided to Older People Residing in Nursing Homes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. Drugs Aging 39, 773–794 (2022). https://doi.org/10.1007/s40266-022-00978-3

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