Abstract
Background
There is strong evidence that potentially inappropriate prescribing is associated with falls in older adults. Fall-related hospitalizations should trigger medication review.
Objectives
The aim of this before-and-after cohort study was to explore patterns of relevant potentially inappropriate prescribing in older people with fall-related hospitalizations.
Methods
Data on older adults with hospitalizations for falls, fractures and syncope between 2012 and 2016 were collected from 44 general practices in Ireland. Fall-related prescribing was defined from the Screening Tool for Older Persons’ Prescriptions (sedatives and vasodilators) and the Screening Tool to Alert doctors to Right Treatment (vitamin D). Prevalence of prescriptions were estimated from general practice and hospital discharge records. Mixed-effects logistic regression was conducted to compare the 12-month pre- and post-hospitalization periods.
Results
Overall, 927 individuals (68% female, average age 81.2 years; standard deviation 8.6) were included, 45% of whom had a diagnosis of fracture, 28% had syncope, and 27% had a fall without fracture/syncope. After adjustment for covariates and practice clustering effects, both vitamin D and sedatives had higher odds of prescription post-hospitalization (adjusted odds ratio [aOR] 4.47, 95% confidence interval [CI] 2.09–9.54, and aOR 1.75, 95% CI 1.29–2.39, respectively). With adjustments for age and sex, having a fracture was associated with new initiation of vitamin D (aOR 2.81, 95% CI 1.76–4.46) and having syncope was associated with continuing on vasodilators (aOR 1.99, 95% CI 1.06–3.74). No factors were associated with new sedative initiation.
Conclusion
Fall-related potentially inappropriate prescribing is prevalent in older adults who have a history of falls, and continues after discharge from hospital. Future studies should investigate why such prescribing is initiated after a fall-related hospitalization, and explore interventions that could reduce such hazardous prescribing.
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Acknowledgements
The authors gratefully acknowledge the contributions of all participating general practitioners and patients.
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Funding
This study was funded by the Health Research Board (HRB) in Ireland through Grant no. HRC/2014/1 (TF).
Conflicts of interest
Mary E. Walsh, Fiona Boland, Frank Moriarty and Tom Fahey declare that they have no conflicts of interest.
Ethical approval
All procedures performed in this study were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required.
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Walsh, M.E., Boland, F., Moriarty, F. et al. Modification of Potentially Inappropriate Prescribing Following Fall-Related Hospitalizations in Older Adults. Drugs Aging 36, 461–470 (2019). https://doi.org/10.1007/s40266-019-00646-z
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DOI: https://doi.org/10.1007/s40266-019-00646-z