Interest in the medicinal use of cannabis and cannabinoids is mounting worldwide. Fueled by enthusiastic media coverage, patients perceive cannabinoids as a natural remedy for many symptoms. Cannabinoid use is of particular interest for older individuals who may experience symptoms such as chronic pain, sleep disturbance, cancer-related symptoms and mood disorders, all of which are often poorly controlled by current drug treatments that may also incur medication-induced side effects. This review provides a summary of the evidence for use of cannabinoids, and medical cannabis in particular, for this age group, with attention to efficacy and harms. Evidence of efficacy for relief of an array of symptoms is overall scanty, and almost all study participants are aged < 60 years. The risk of known and potential adverse effects is considerable, with concerns for cognitive, cardiovascular and gait and stability effects in older adults. Finally, in light of the paucity of clinical evidence and increasing patient requests for information or use, we propose a pragmatic clinical approach to a rational dialogue with older patients, highlighting the importance of individual benefit–risk assessment and shared patient–clinician decision making.
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Conflict of interest
AM and WH have no conflicts of interest. MAF has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, UCB Canada, Palladin Labs, and Pfizer in the last 3 years.
No sources of funding were used in the preparation of this manuscript.
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Minerbi, A., Häuser, W. & Fitzcharles, MA. Medical Cannabis for Older Patients. Drugs Aging 36, 39–51 (2019). https://doi.org/10.1007/s40266-018-0616-5