Drugs & Aging

, Volume 35, Issue 5, pp 399–408 | Cite as

A Glimpse into Uveitis in the Aging Eye: Pathophysiology, Clinical Presentation and Treatment Considerations

  • Elizabeth Akinsoji
  • Raquel Goldhardt
  • Anat Galor
Review Article


Uveitis describes a group of inflammatory conditions of the eye that have various underlying causes and clinical presentations. Susceptibilities to uveitis in the elderly may be attributed to age-related risk factors such as immunosenescence, increased immunological inflammatory mediators, and autoimmunity. Overall, anterior uveitis is more common than posterior and panuveitis in the general population and also in the elderly. Some causes of uveitis in the elderly are herpes simplex virus, ocular ischemic syndrome, sarcoidosis, and central nervous system lymphoma, and these will be discussed in detail herein. Eye care professionals need to consider the wide differential for uveitis, obtain the appropriate history, conduct a detailed clinical examination, and tailor management to the clinical presentation and underlying cause of disease. The challenges of polypharmacy and nonadherence in the elderly impact patient outcomes and must be taken into consideration when considering treatment.


Compliance with Ethical Standards

Conflict of interest

No conflicting relationship exists for any author.

Financial support

Supported by the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Clinical Sciences Research EPID-006-15S (Dr. Galor), R01EY026174 (Dr. Galor), NIH Center Core Grant P30EY014801 and Research to Prevent Blindness Unrestricted Grant.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Elizabeth Akinsoji
    • 1
  • Raquel Goldhardt
    • 1
    • 2
    • 3
  • Anat Galor
    • 1
    • 2
    • 3
  1. 1.University of Miami Miller School of MedicineMiamiUSA
  2. 2.Miami Veterans Administration Medical CenterMiamiUSA
  3. 3.Bascom Palmer Eye Institute, University of Miami Miller School of MedicineMiamiUSA

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