Skip to main content

Advertisement

Log in

Leukotriene Receptor Antagonists for the Treatment of Asthma in Elderly Patients

  • Review Article
  • Published:
Drugs & Aging Aims and scope Submit manuscript

Abstract

Elderly asthma (EA) is regarded as a distinct phenotype of asthma and is associated with age-related changes in airway structure and alterations in lung function and immune responses. EA is difficult to diagnose because of aging and co-morbidities, and overlaps with fixed airway obstructive disease. Novel modalities to differentiate between EA and chronic obstructive pulmonary disease (COPD) are necessary. A multifaceted approach, including clinical history, smoking habits, atopy, and measurement of lung function, is mandatory to differentiate asthma from COPD. There are a variety of co-morbidities with EA, of which COPD, upper airway diseases, depression, obesity, and hypertension are the most common, and these co-morbidities can affect the control status of EA. However, leukotriene receptor antagonists (LTRAs) can facilitate the management of EA, and thus addition of an LTRA to inhaled corticosteroid (ICS) monotherapy or ICS plus long-acting β2-agonist therapy improves symptoms in EA patients. LTRA treatment is safe and beneficial in patients who are unable to use inhalation devices properly or who have co-morbid diseases. Therefore, clinical studies targeting a specific population of EA patients are warranted to help achieve a better therapeutic strategy in EA patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Yáñez A, Cho S-H, Soriano JB, Rosenwasser LJ, Rodrigo GJ, Rabe KF, et al. Asthma in the elderly: what we know and what we have yet to know. World Allergy Organ J. 2014;7:8.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  2. Song WJ, Jee YK. More effective strategies are needed for elderly asthmatics in real-world practice. Allergy Asthma Immunol Res. 2015;7:419–20.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Wolff JL, Starfield B, Anderson G. Prevalence, expenditures, and complications of multiple chronic conditions in the elderly. Arch Intern Med. 2002;162:2269–76.

    Article  PubMed  Google Scholar 

  4. Tsai CL, Lee WY, Hanania NA, Camargo CA Jr. Age-related differences in clinical outcomes for acute asthma in the United States, 2006–2008. J Allergy Clin Immunol. 2012;129(1252–8):e1.

    PubMed  Google Scholar 

  5. Bellia V, Pedone C, Catalano F, Zito A, Davì E, Palange S, et al. Asthma in the elderly: mortality rate and associated risk factors for mortality. Chest. 2007;132:1175–82.

    Article  PubMed  Google Scholar 

  6. Park HW, Kim TW, Song WJ, Kim SH, Park HK, Kim SH, et al. Prediction of asthma exacerbations in elderly adults: results of a 1-year prospective study. J Am Geriatr Soc. 2013;61:1631–2.

    Article  PubMed  Google Scholar 

  7. Ban GY, Ye YM, Lee Y, Kim JE, Nam YH, Lee SK, et al. Predictors of asthma control by stepwise treatment in elderly asthmatic patients. J Korean Med Sci. 2015;30:1042–7.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Hwang EK, Jin HJ, Nam YH, Shin YS, Ye YM, Nahm DH, et al. The predictors of poorly controlled asthma in elderly. Allergy Asthma Immunol Res. 2012;4:270–6.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Hanania NA, King MJ, Braman SS, Saltoun C, Wise RA, Enright P, et al. Asthma in the elderly: current understanding and future research needs—a report of a National Institute on Aging (NIA) workshop. J Allergy Clin Immunol. 2011;128:S4–24.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Battaglia S, Basile M, Spatafora M, Scichilone N. Are asthmatics enrolled in randomized trials representative of real-life outpatients. Respiration. 2015;89:383–9.

    Article  CAS  PubMed  Google Scholar 

  11. Ban GY, Trinh TH, Ye YM, Park HS. Predictors of asthma control in elderly patients. Curr Opin Allergy Clin Immunol. 2016;16:237–43.

    Article  CAS  PubMed  Google Scholar 

  12. Abramson MJ, Perret JL, Dharmage SC, McDonald VM, McDonald CF. Distinguishing adult-onset asthma from COPD: a review and a new approach. Int J Chron Obstruct Pulmon Dis. 2014;9:945.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Ross JA, Yang Y, Song PX, Clark NM, Baptist AP. Quality of life, health care utilization, and control in older adults with asthma. J Allergy Clin Immunol Pract. 2013;1:157–62.

    Article  PubMed  Google Scholar 

  14. Lee SM, Chang YS, Kim CW, Kim TB, Kim SH, Kwon YE, et al. Skills in handling turbuhaler, diskus, and pressurized metered-dose inhaler in Korean asthmatic patients. Allergy Asthma Immunol Res. 2011;3:46–52.

    Article  PubMed  Google Scholar 

  15. Kanaoka Y, Boyce JA. Cysteinyl leukotrienes and their receptors; emerging concepts. Allergy Asthma Immunol Res. 2014;6:288–95.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Chauhan BF, Ducharme FM. Anti-leukotriene agents compared to inhaled corticosteroids in the management of recurrent and/or chronic asthma in adults and children. Cochrane Database Syst Rev. 2012;(5):CD002314.

  17. Boulet L-P. Asthma in the elderly patient. Asthma Res Pract. 2016;2:3. doi:10.1186/s40733-015-0015-1.

    Article  Google Scholar 

  18. Battaglia S, Benfante A, Spatafora M, Scichilone N. Asthma in the elderly: a different disease? Breathe. 2016;12:18.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Song WJ, Cho SH. Challenges in the management of asthma in the elderly. Allergy Asthma Immunol Res. 2015;7:431–9.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Larj M, Georas S, Smith SM, Khurana S, Bhaskar J. Differences between early-and late-onset asthma; data from an asthma registry. B14. Asthma phenotyping: understanding of pathogenesis and rationale for new therapies. Am Thoracic Soc; 2013. p. A2325-A.

  21. de Nijs SB, Venekamp LN, Bel EH. Adult-onset asthma: is it really different? Eur Respir Rev. 2013;22:44–52.

    Article  PubMed  Google Scholar 

  22. Rönmark E, Lindberg A, Watson L, Lundbäck B. Outcome and severity of adult onset asthma—report from the obstructive lung disease in northern Sweden studies (OLIN). Respir Med. 2007;101:2370–7.

    Article  PubMed  Google Scholar 

  23. Park J, Kim TB, Joo H, Lee JS, Lee SD, Oh YM. Diseases concomitant with asthma in middle-aged and elderly subjects in Korea: a population-based study. Allergy Asthma Immunol Res. 2013;5:16–25.

    Article  PubMed  Google Scholar 

  24. Lindner K, Panaszek B, Machaj Z. Asthma in the elderly. Pol Arch Med Wewn. 2007;117:350–4.

    PubMed  Google Scholar 

  25. Zureik M, Orehek J. Diagnosis and severity of asthma in the elderly: results of a large survey in 1485 asthmatics recruited by lung specialists. Respiration. 2002;69:223–8.

    Article  PubMed  Google Scholar 

  26. Gibson PG, McDonald VM, Marks GB. Asthma in older adults. Lancet. 2010;376:803–13.

    Article  PubMed  Google Scholar 

  27. Mathur SK, Nyenhuis SM. Changes in immune function in asthma in the elderly. Aging Health. 2009;5:551–9.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Benfante A, Scichilone N. The geriatric asthma: pitfalls and challenges. Asthma Res Pract. 2016;2:1–4.

    Article  Google Scholar 

  29. Ding DJ, Martin J, Macklem P. Effects of lung volume on maximal methacholine-induced bronchoconstriction in normal humans. J Appl Physiol. 1987;62:1324–30.

    Article  CAS  PubMed  Google Scholar 

  30. Sharma G, Goodwin J. Effect of aging on respiratory system physiology and immunology. Clin Interv Aging. 2006;1:253.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Murray MA, Chotirmall SH. The impact of immunosenescence on pulmonary disease. Mediat Inflamm. 2015;2015:692546.

    Article  CAS  Google Scholar 

  32. Agarwal S, Busse PJ. Innate and adaptive immunosenescence. Ann Allergy Asthma Immunol. 2010;104:183–90 (quiz 90-2, 210).

  33. Tzortzaki EG, Proklou A, Siafakas NM. Asthma in the elderly: can we distinguish it from COPD? J Allergy. 2011;2011:843543. doi:10.1155/2011/843543.

    Article  Google Scholar 

  34. Ducharme ME, Prince P, Hassan N, Nair P, Boulet LP. Expiratory flows and airway inflammation in elderly asthmatic patients. Respir Med. 2011;105:1284–9.

    Article  PubMed  Google Scholar 

  35. Porsbjerg CM, Gibson PG, Pretto JJ, Salome CM, Brown NJ, Berend N, et al. Relationship between airway pathophysiology and airway inflammation in older asthmatics. Respirology. 2013;18:1128–34.

    PubMed  Google Scholar 

  36. Meyer KC, Rosenthal NS, Soergel P, Peterson K. Neutrophils and low-grade inflammation in the seemingly normal aging human lung. Mech Ageing Dev. 1998;104:169–81.

    Article  CAS  PubMed  Google Scholar 

  37. Chotirmall SH, Burke CM. Aging and the microbiome: implications for asthma in the elderly? Expert Rev Respir Med. 2015;9:125–8.

    Article  CAS  PubMed  Google Scholar 

  38. Gollwitzer ES, Saglani S, Trompette A, Yadava K, Sherburn R, McCoy KD, et al. Lung microbiota promotes tolerance to allergens in neonates via PD-L1. Nat Med. 2014;20:642–7.

    Article  CAS  PubMed  Google Scholar 

  39. Global Initiative for Asthma. Global strategy for asthma management and prevention (updated 2015). http://www.ginasthma.org. Accessed 15 Mar 2016.

  40. Demoly P, Paggiaro P, Plaza V, Bolge S, Kannan H, Sohier B, et al. Prevalence of asthma control among adults in France, Germany, Italy, Spain and the UK. Eur Respir Rev. 2009;18:105–12.

    Article  CAS  PubMed  Google Scholar 

  41. Bozek A, Filipowski M, Fischer A, Jarzab J. Characteristics of atopic bronchial asthma in seniors over 80 years of age. Biomed Res Int. 2013;2013:689782.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Chotirmall SH, Watts M, Branagan P, Donegan CF, Moore A, McElvaney NG. Diagnosis and management of asthma in older adults. J Am Geriatr Soc. 2009;57:901–9.

    Article  PubMed  Google Scholar 

  43. Bellia V, Pistelli R, Catalano F, Antonelli-Incalzi R, Grassi V, Melillo G, et al. Quality control of spirometry in the elderly: the SA.RA study. Am J Respir Crit Care Med. 2000;161:1094–100.

    Article  CAS  PubMed  Google Scholar 

  44. Haynes JM. Pulmonary function test quality in the elderly: a comparison with younger adults. Respir Care. 2014;59:16–21.

    Article  PubMed  Google Scholar 

  45. Allen SC, Baxter M. A comparison of four tests of cognition as predictors of inability to perform spirometry in old age. Age Ageing. 2009;38(5):537–41.

    Article  PubMed  Google Scholar 

  46. Enright PL, Kronmal RA, Higgins M, Schenker M, Haponik EF. Spirometry reference values for women and men 65 to 85 years of age. Am Rev Respir Dis. 1993;147:e133.

    Article  Google Scholar 

  47. Sorino C, Sherrill D, Guerra S, Enright P, Pedone C, Augugliaro G, et al. Prognostic value of FEV1/FEV6 in elderly people. Clin Physiol Funct Imaging. 2011;31:101–7.

    PubMed  Google Scholar 

  48. Cuttitta G, Cibella F, Bellia V, Grassi V, Cossi S, Bucchieri S, et al. Changes in FVC during methacholine-induced bronchoconstriction in elderly patients with asthma: bronchial hyperresponsiveness and aging. Chest. 2001;119:1685–90.

    Article  CAS  PubMed  Google Scholar 

  49. Gergen PJ, Arbes SJ Jr, Calatroni A, Mitchell HE, Zeldin DC. Total IgE levels and asthma prevalence in the US population: results from the National Health and Nutrition Examination Survey 2005-2006. J Allergy Clin Immunol. 2009;124:447–53.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Litonjua AA, Sparrow D, Weiss ST, O’Connor GT, Long AA, Ohman JL Jr. Sensitization to cat allergen is associated with asthma in older men and predicts new-onset airway hyperresponsiveness: the Normative Aging Study. Am J Respir Crit Care Med. 1997;156:23–7.

    Article  CAS  PubMed  Google Scholar 

  51. King MJ, Bukantz SC, Phillips S, Mohapatra SS, Tamulis T, Lockey RF. Serum total IgE and specific IgE to Dermatophagoides pteronyssinus, but not eosinophil cationic protein, are more likely to be elevated in elderly asthmatic patients. Allergy Asthma Proc. 2004;25(5):321–5.

    CAS  PubMed  Google Scholar 

  52. Bellia V, Battaglia S, Catalano F, Scichilone N, Incalzi RA, Imperiale C, et al. Aging and disability affect misdiagnosis of COPD in elderly asthmatics: the SARA study. Chest. 2003;123:1066–72.

    Article  PubMed  Google Scholar 

  53. Sin B, Akkoca O, Saryal S, Oner F, Misirligil Z. Differences between asthma and COPD in the elderly. J Investig Allergol Clin Immunol. 2006;16:44–50.

    CAS  PubMed  Google Scholar 

  54. Tamada T, Sugiura H, Takahashi T, Matsunaga K, Kimura K, Katsumata U, et al. Biomarker-based detection of asthma-COPD overlap syndrome in COPD populations. Int J Chron Obstruct Pulmon Dis. 2015;10:2169–76.

    Article  PubMed  PubMed Central  Google Scholar 

  55. Columbo M, Wong B, Panettieri RA, Rohr AS. Asthma in the elderly: the role of exhaled nitric oxide measurements. Respir Med. 2013;107:785–7.

    Article  PubMed  PubMed Central  Google Scholar 

  56. Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease (updated 2015). http://www.goldcopd.org. Accessed 15 Mar 2016.

  57. Di Lorenzo G, Mansueto P, Ditta V, Esposito-Pellitteri M, Bianco CL, Leto-Barone MS, et al. Similarity and differences in elderly patients with fixed airflow obstruction by asthma and by chronic obstructive pulmonary disease. Respir Med. 2008;102:232–8.

    Article  PubMed  Google Scholar 

  58. Gelb AF, Yamamoto A, Mauad T, Kollin J, Schein MJ, Nadel JA. Unsuspected mild emphysema in nonsmoking patients with chronic asthma with persistent airway obstruction. J Allergy Clin Immunol. 2014;133:263–5.e1–3.

  59. de Marco R, Cappa V, Accordini S, Rava M, Antonicelli L, Bortolami O, et al. Trends in the prevalence of asthma and allergic rhinitis in Italy between 1991 and 2010. Eur Respir J. 2012;39:883–92.

    Article  PubMed  Google Scholar 

  60. Simpson JL, Scott R, Boyle MJ, Gibson PG. Inflammatory subtypes in asthma: assessment and identification using induced sputum. Respirology. 2006;11:54–61.

    Article  PubMed  Google Scholar 

  61. D’silva L, Hassan N, Wang H-Y, Kjarsgaard M, Efthimiadis A, Hargreave FE, et al. Heterogeneity of bronchitis in airway diseases in tertiary care clinical practice. Can Respir J. 2011;18:144–8.

  62. Wardzynska A, Kubsik B, Kowalski ML. Comorbidities in elderly patients with asthma: association with control of the disease and concomitant treatment. Geriatr Gerontol Int. 2015;15:902–9.

    Article  PubMed  Google Scholar 

  63. Haselkorn T, Chen H, Miller DP, Fish JE, Peters SP, Weiss ST, et al. Asthma control and activity limitations: insights from the Real-world Evaluation of Asthma Control and Treatment (REACT) study. Ann Allergy Asthma Immunol. 2010;104:471–7.

    Article  PubMed  Google Scholar 

  64. Adams RJ, Wilson DH, Taylor AW, Daly A, Tursan d’Espaignet E, Dal Grande E, et al. Coexistent chronic conditions and asthma quality of life: a population-based study. Chest. 2006;129:285–91.

    Article  PubMed  Google Scholar 

  65. Agusta F, Battaglia S, Benfante A, Spatafora M, Scichilone N. Challenges in the pharmacological treatment of geriatric asthma. Expert Rev Clin Pharmacol. 2016;9(7):917–26.

    Article  CAS  PubMed  Google Scholar 

  66. Patel MR, Janevic MR, Heeringa SG, Baptist AP, Clark NM. An examination of adverse asthma outcomes in U.S. adults with multiple morbidities. Ann Am Thorac Soc. 2013;10:426–31.

  67. Zeki AA, Schivo M, Chan A, Albertson TE, Louie S. The asthma-COPD overlap syndrome: a common clinical problem in the elderly. J Allergy (Cairo). 2011;2011:861926.

    PubMed Central  Google Scholar 

  68. Garin N, Koyanagi A, Chatterji S, Tyrovolas S, Olaya B, Leonardi M, et al. Global multimorbidity patterns: a cross-sectional, population-based, multi-country study. J Gerontol A Biol Sci Med Sci. 2016;71:205–14.

    Article  PubMed  Google Scholar 

  69. Milanese M, Di Marco F, Corsico AG, Rolla G, Sposato B, Chieco-Bianchi F, ELSA Study Group, et al. Asthma control in elderly asthmatics. An Italian observational study. Respir Med. 2014;108:1091–9.

    Article  CAS  PubMed  Google Scholar 

  70. Kauppi P, Kupiainen H, Lindqvist A, Tammilehto L, Kilpeläinen M, Kinnula VL, et al. Overlap syndrome of asthma and COPD predicts low quality of life. J Asthma. 2011;48:279–85.

    Article  PubMed  Google Scholar 

  71. Gerhardsson de Verdier M, Andersson M, Kern DM, Zhou S, Tunceli O. Asthma and chronic obstructive pulmonary disease overlap syndrome: doubled costs compared with patients with asthma alone. Value Health. 2015;18:759–66.

    Article  PubMed  Google Scholar 

  72. Menezes AM, Montes de Oca M, Perez-Padilla R, Nadeau G, Wehrmeister FC, Lopez-Varela MV, et al. Increased risk of exacerbation and hospitalization in subjects with an overlap phenotype: COPD-asthma. Chest. 2014;145:297–304.

    Article  PubMed  Google Scholar 

  73. Lee JH, Chung JW, Kong KA, Lee S, Ryu YJ, Chang JH. Characteristics and self-rated health of overlap syndrome. Int J Chron Obstruct Pulmon Dis. 2014;9:795–804.

    Article  PubMed  PubMed Central  Google Scholar 

  74. van den Berge M, Aalbers R. The asthma-COPD overlap syndrome: how is it defined and what are its clinical implications? J Asthma Allergy. 2016;9:27–35.

    PubMed  PubMed Central  Google Scholar 

  75. Alvarado-Gonzalez A, Arce I. Tiotropium bromide in chronic obstructive pulmonary disease and bronchial asthma. J Clin Med Res. 2015;7:831–9.

    Article  PubMed  PubMed Central  Google Scholar 

  76. Barrecheguren M, Monteagudo M, Ferrer J, Borrell E, Llor C, Esquinas C, et al. Treatment patterns in COPD patients newly diagnosed in primary care. A population-based study. Respir Med. 2016;111:47–53.

    Article  PubMed  Google Scholar 

  77. Postma DS, Rabe KF. The asthma-COPD overlap syndrome. N Engl J Med. 2015;373:1241–9.

    Article  CAS  PubMed  Google Scholar 

  78. Wuthrich B, Schmid-Grendelmeier P, Schindler C, Imboden M, Bircher A, Zemp E, et al. Prevalence of atopy and respiratory allergic diseases in the elderly SAPALDIA population. Int Arch Allergy Immunol. 2013;162:143–8.

    Article  PubMed  Google Scholar 

  79. Jarvis D, Newson R, Lotvall J, Hastan D, Tomassen P, Keil T, et al. Asthma in adults and its association with chronic rhinosinusitis: the GA(2)LEN survey in Europe. Allergy. 2012;67:91–8.

    Article  CAS  PubMed  Google Scholar 

  80. Ek A, Middelveld RJ, Bertilsson H, Bjerg A, Ekerljung L, Malinovschi A, et al. Chronic rhinosinusitis in asthma is a negative predictor of quality of life: results from the Swedish GA(2)LEN survey. Allergy. 2013;68:1314–21.

    Article  CAS  PubMed  Google Scholar 

  81. Song WJ, Sintobin I, Sohn KH, Kang MG, Park HK, Jo EJ, et al. Staphylococcal enterotoxin IgE sensitization in late-onset severe eosinophilic asthma in the elderly. Clin Exp Allergy. 2016;46(3):411–21.

    Article  CAS  PubMed  Google Scholar 

  82. Lombardi C, Raffetti E, Caminati M, Liccardi G, Passalacqua G, Reccardini F, et al. Phenotyping asthma in the elderly: allergic sensitization profile and upper airways comorbidity in patients older than 65 years. Ann Allergy Asthma Immunol. 2016;116(3):206–11.

    Article  PubMed  Google Scholar 

  83. Pite H, Pereira AM, Morais-Almeida M, Nunes C, Bousquet J, Fonseca JA. Prevalence of asthma and its association with rhinitis in the elderly. Respir Med. 2014;108:1117–26.

    Article  CAS  PubMed  Google Scholar 

  84. Kvamme J-M, Wilsgaard T, Florholmen J, Jacobsen BK. Body mass index and disease burden in elderly men and women: the Tromsø Study. Eur J Epidemiol. 2010;25:183–93.

    Article  PubMed  Google Scholar 

  85. Leone N, Courbon D, Berr C, Barberger-Gateau P, Tzourio C, Alperovitch A, et al. Abdominal obesity and late-onset asthma: cross-sectional and longitudinal results: the 3C study. Obesity (Silver Spring). 2012;20:628–35.

    Article  PubMed  Google Scholar 

  86. Song WJ, Kim SH, Lim S, Park YJ, Kim MH, Lee SM, et al. Association between obesity and asthma in the elderly population: potential roles of abdominal subcutaneous adiposity and sarcopenia. Ann Allergy Asthma Immunol. 2012;109:243–8.

    Article  PubMed  Google Scholar 

  87. Peters MC, Fahy JV. Metabolic consequences of obesity as an “outside in” mechanism of disease severity in asthma. Eur Respir J. 2016;48:291–3.

    Article  PubMed  Google Scholar 

  88. Celebi Sozener Z, Aydin O, Mungan D, Misirligil Z. Obesity-asthma phenotype: effect of weight gain on asthma control in adults. Allergy Asthma Proc. 2016;37:311–7.

  89. Kim SH, Sutherland ER, Gelfand EW. Is there a link between obesity and asthma? Allergy Asthma Immunol Res. 2014;6:189–95.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  90. Sutherland ER. Linking obesity and asthma. Ann N Y Acad Sci. 2014;1311:31–41.

    Article  CAS  PubMed  Google Scholar 

  91. Boulet LP. Influence of comorbid conditions on asthma. Eur Respir J. 2009;33:897–906.

    Article  PubMed  Google Scholar 

  92. Park HW, Song WJ, Kim SH, Park HK, Kwon YE, Kwon HS, et al. Classification and implementation of asthma phenotypes in elderly patients. Ann Allergy Asthma Immunol. 2015;114:18–22.

    Article  PubMed  Google Scholar 

  93. Choi GS, Shin YS, Kim JH, Choi SY, Lee SK, Nam YH, et al. Prevalence and risk factors for depression in Korean adult patients with asthma: is there a difference between elderly and non-elderly patients? J Korean Med Sci. 2014;29:1626–31.

    Article  PubMed  PubMed Central  Google Scholar 

  94. Gao YH, Zhao HS, Zhang FR, Gao Y, Shen P, Chen RC, et al. The relationship between depression and asthma: a meta-analysis of prospective studies. PLoS One. 2015;10:e0132424.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  95. Hutter N, Knecht A, Baumeister H. Health care costs in persons with asthma and comorbid mental disorders: a systematic review. Gen Hosp Psychiatry. 2011;33:443–53.

    Article  PubMed  Google Scholar 

  96. Krauskopf KA, Sofianou A, Goel MS, Wolf MS, Wilson EA, Martynenko ME, et al. Depressive symptoms, low adherence, and poor asthma outcomes in the elderly. J Asthma. 2013;50:260–6.

    Article  PubMed  Google Scholar 

  97. Han YY, Forno E, Marsland AL, Miller GE, Celedon JC. Depression, asthma, and bronchodilator response in a nationwide study of US Adults. J Allergy Clin Immunol Pract. 2016;4(68–73):e1.

    PubMed  Google Scholar 

  98. Gerald JK, Moreno FA. Asthma and depression: it’s complicated. J Allergy Clin Immunol Pract. 2016;4:74–5.

    Article  PubMed  Google Scholar 

  99. Christiansen SC, Schatz M, Yang SJ, Ngor E, Chen W, Zuraw BL. Hypertension and asthma: a comorbid relationship. J Allergy Clin Immunol Pract. 2016;4:76–81.

    Article  PubMed  Google Scholar 

  100. Christiansen CF, Christensen S, Mehnert F, Cummings SR, Chapurlat RD, Sorensen HT. Glucocorticoid use and risk of atrial fibrillation or flutter: a population-based, case-control study. Arch Intern Med. 2009;169:1677–83.

    Article  PubMed  Google Scholar 

  101. Dogra S, Ardern CI, Baker J. The relationship between age of asthma onset and cardiovascular disease in Canadians. J Asthma. 2007;44:849–54.

    Article  PubMed  Google Scholar 

  102. Lee HM, Truong ST, Wong ND. Association of adult-onset asthma with specific cardiovascular conditions. Respir Med. 2012;106:948–53.

    Article  PubMed  Google Scholar 

  103. Ferguson S, Teodorescu MC, Gangnon RE, Peterson AG, Consens FB, Chervin RD, et al. Factors associated with systemic hypertension in asthma. Lung. 2014;192:675–83.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  104. Vaquerizo M, Casan P, Castillo J, Perpina M, Sanchis J, Sobradillo V, et al. Effect of montelukast added to inhaled budesonide on control of mild to moderate asthma. Thorax. 2003;58:204–10.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  105. Storms W, Michele T, Knorr B, Noonan G, Shapiro G, Zhang J, et al. Clinical safety and tolerability of montelukast, a leukotriene receptor antagonist, in controlled clinical trials in patients aged ≥6 years. Clin Exp Allergy. 2001;31:77–87.

    Article  CAS  PubMed  Google Scholar 

  106. Williams B, Noonan G, Reiss T, Knorr B, Guerra J, White R, et al. Long-term asthma control with oral montelukast and inhaled beclomethasone for adults and children 6 years and older. Clin Exp Allergy. 2001;31:845–54.

    Article  CAS  PubMed  Google Scholar 

  107. Rand C, Bilderback A, Schiller K, Edelman JM, Hustad CM, Zeiger RS, et al. Adherence with montelukast or fluticasone in a long-term clinical trial: results from the mild asthma montelukast versus inhaled corticosteroid trial. J Allergy Clin Immunol. 2007;119:916–23.

    Article  CAS  PubMed  Google Scholar 

  108. Pearlman DS, White MV, Lieberman AK, Pepsin PJ, Kalberg C, Emmett A, et al. Fluticasone propionate/salmeterol combination compared with montelukast for the treatment of persistent asthma. Ann Allergy Asthma Immunol. 2002;88:227–35.

    Article  CAS  PubMed  Google Scholar 

  109. Bozek A, Warkocka-Szoltysek B, Filipowska-Gronska A, Jarzab J. Montelukast as an add-on therapy to inhaled corticosteroids in the treatment of severe asthma in elderly patients. J Asthma. 2012;49:530–4.

    Article  CAS  PubMed  Google Scholar 

  110. Korenblat PE, Kemp JP, Scherger JE, Minkwitz MC, Mezzanotte W. Effect of age on response to zafirlukast in patients with asthma in the Accolate Clinical Experience and Pharmacoepidemiology Trial (ACCEPT). Ann Allergy Asthma Immunol. 2000;84:217–25.

    Article  CAS  PubMed  Google Scholar 

  111. Horiguchi T, Tachikawa S, Kondo R, Miyazaki J, Shiga M, Hirose M, et al. Comparative evaluation of the leukotriene receptor antagonist pranlukast versus the steroid inhalant fluticasone in the therapy of aged patients with mild bronchial asthma. Arzneimittelforschung. 2006;57:87–91.

    Google Scholar 

  112. Ye YM, Kim SH, Hur GY, Kim JH, Park JW, Shim JJ, et al. Addition of montelukast to low-dose inhaled corticosteroid leads to fewer exacerbations in older patients than medium-dose inhaled corticosteroid monotherapy. Allergy Asthma Immunol Res. 2015;7:440–8.

    Article  PubMed  PubMed Central  Google Scholar 

  113. Health Products Regulatory Authority. Summary of product characteristics. 2016. https://www.hpra.ie/img/uploaded/swedocuments/LicenseSPC_PA1390-030-003_19062015140038.pdf. Accessed 17 June 2016.

  114. Federman AD, Wolf MS, Sofianou A, Martynenko M, O’Connor R, Halm EA, et al. Self-management behaviors in older adults with asthma: associations with health literacy. J Am Geriatr Soc. 2014;62:872–9.

    Article  PubMed  PubMed Central  Google Scholar 

  115. Scichilone N, Battaglia S, Benfante A, Bellia V. Safety and efficacy of montelukast as adjunctive therapy for treatment of asthma in elderly patients. Clin Interv Aging. 2013;8:1329–37.

    PubMed  PubMed Central  Google Scholar 

  116. Fabbri LM, Romagnoli M, Corbetta L, Casoni G, Busljetic K, Turato G, et al. Differences in airway inflammation in patients with fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2003;167:418–24.

    Article  PubMed  Google Scholar 

  117. Gangemi S, Pescara L, D’Urbano E, Basile G, Nicita-Mauro V, Davì G, et al. Aging is characterized by a profound reduction in anti-inflammatory lipoxin A4 levels. Exp Gerontol. 2005;40:612–4.

    Article  CAS  PubMed  Google Scholar 

  118. Ingelsson E, Yin L, Bäck M. Nationwide cohort study of the leukotriene receptor antagonist montelukast and incident or recurrent cardiovascular disease. J Allergy Clin Immunol. 2012;129(702–7):e2.

    PubMed  Google Scholar 

  119. Barnes N, Thomas M, Price D, Tate H. The national montelukast survey. J Allergy Clin Immunol. 2005;115:47–54.

    Article  PubMed  Google Scholar 

  120. Weinreich UM, Thomsen LP, Brock C, Karbing DS, Rees SE. Diffusion capacity of the lung for carbon monoxide—a potential marker of impaired gas exchange or of systemic deconditioning in chronic obstructive lung disease? Chron Respir Dis. 2015;12:357–64.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Hae-Sim Park.

Ethics declarations

Funding

This research was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health & Welfare, Republic of Korea (HI16C0992)

Conflict of interest

HKT Trinh, GY Ban, JH Lee, HS Park declare no conflicts of interest in relation to the contents of this review.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Trinh, H.K.T., Ban, GY., Lee, JH. et al. Leukotriene Receptor Antagonists for the Treatment of Asthma in Elderly Patients. Drugs Aging 33, 699–710 (2016). https://doi.org/10.1007/s40266-016-0401-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40266-016-0401-2

Keywords

Navigation