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Drugs & Aging

, Volume 33, Issue 2, pp 159–160 | Cite as

Comment on: Pharmacokinetics of Tramadol and O-Desmethyltramadol Enantiomers Following Administration of Extended-Release Tablets to Elderly and Young Subjects

  • Karel Allegaert
Letter to the Editor

Keywords

Tramadol Renal Clearance Early Infancy Hepatic Clearance Hepatic Drug Metabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Compliance with ethical standards

Conflict of interest

KA has no conflicts of interest or funding related to the compound to report.

Funding

KA is supported by the Fund for Scientific Research, Flanders (Fundamental Clinical Investigatorship 1800214N) and the research activities are further facilitated by the Agency for Innovation by Science and Technology in Flanders (SAFEPEDRUG project, IWT/SBO 130033).

References

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    Skinner-Robertson S, Fradette C, Bouchard S, Mouksassi MS, Varin F. Pharmacokinetics of tramadol and O-desmethyltramadol enantiomers following administration of extended-release tablets to elderly and young subjects. Drugs Aging. 2015;32:1029–43.CrossRefPubMedGoogle Scholar
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    Samant TS, Mangal N, Lukacova V, Schmidt S. Quantitative clinical pharmacology for size and age scaling in pediatric drug development: a systematic review. J Clin Pharmacol. 2015;55:1207–17.CrossRefPubMedGoogle Scholar
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    Allegaert K, Rochette A, Veyckemans F. Developmental pharmacology of tramadol during infancy: ontogeny, pharmacogenetics and elimination clearance. Pediatr Anesth. 2011;21:266–73.CrossRefGoogle Scholar
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    Allegaert K, Holford N, Anderson BJ, Holford S, Stuber F, Rochette A, Troconiz IF, Beier H, de Hoon JN, Pedersen RQS, Stamer U. Tramadol and O-desmethyl tramadol clearance maturation and disposition in humans: a pooled pharmacokinetic study. Clin Pharmacokinet. 2015;54:167–78.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Neonatal Intensive Care UnitUniversity Hospitals LeuvenLouvainBelgium
  2. 2.Department of Development and RegenerationKU LeuvenLouvainBelgium

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