Drugs & Aging

, Volume 32, Issue 7, pp 505–513 | Cite as

Therapeutic Strategies to Treat Dry Eye in an Aging Population

  • Nisreen S. Ezuddin
  • Karam A. Alawa
  • Anat GalorEmail author
Leading Article


Dry eye (DE) is a prevalent ocular disease that primarily affects the elderly. Affecting up to 30 % of adults aged 50 years and older, DE affects both visual function and quality of life. Symptoms of DE, including ocular pain (aching, burning), visual disturbances, and tearing, can be addressed with therapeutic agents that target dysfunction of the meibomian glands, lacrimal glands, goblet cells, ocular surface, and/or neural network. This review provides an overview of the efficacy, use, and limitations of current therapeutic interventions being used to treat DE.


Ocular Surface Lacrimal Gland Tofacitinib Intense Pulse Light Meibomian Gland 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Clinical Sciences Research and Development’s Career Development Award CDA-2-024-10S (Dr. Galor), National Institutes of Health Center Core Grant P30EY014801, and Research to Prevent Blindness unrestricted grant.

Conflicts of interest

Nisreen S. Ezuddin, Karam A. Alawa, and Anat Galor declare no conflicts of interest.


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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Nisreen S. Ezuddin
    • 1
  • Karam A. Alawa
    • 1
  • Anat Galor
    • 1
    • 2
    Email author
  1. 1.Bascom Palmer Eye InstituteUniversity of MiamiMiamiUSA
  2. 2.Miami Veterans Administration Medical CenterMiamiUSA

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