Drugs & Aging

, Volume 31, Issue 6, pp 441–451 | Cite as

Optimal Dosages for Melatonin Supplementation Therapy in Older Adults: A Systematic Review of Current Literature

  • Esmée M. S. VuralEmail author
  • Barbara C. van Munster
  • Sophia E. de Rooij
Review Article



Melatonin is a hormone that regulates circadian rhythm, and its levels decline with age. As melatonin levels decrease, older adults are prone to develop disorders related to an altered circadian rhythm. The effective dose of melatonin supplementation in these disorders remains unclear.


Our objective was to define the optimal dosage of exogenous melatonin administration in disorders related to altered melatonin levels in older adults aged 55 years and above by determining the dose-response effect of exogenous administered melatonin on endogenous levels.


We conducted a systematic review through PubMed/MEDLINE and Embase, both from 1980 until November 2013. Included articles studied the effect of exogenous melatonin administration on endogenous melatonin levels in either serum, urine, or saliva in humans aged 55 years and above.


We included 16 articles, nine of which were randomized controlled trials (RCTs). The mean age varied from 55.3 to 77.6 years. Melatonin dosage varied from 0.1 mg to 50 mg/kg and was administered orally in all studies. Pre- and post-intervention levels revealed a significant elevation of the post-intervention melatonin levels in a dose-dependent fashion. The maximum concentrations measured in serum and urine were all elevated compared with placebo, and a higher elevation in older adults than in younger adults was demonstrated. Even though there were no differences between times to reach maximum concentration in serum and urine, melatonin levels with higher doses were maintained longer above a certain threshold than were lower doses.


In older adults, we advise the use of the lowest possible dose of immediate-release formulation melatonin to best mimic the normal physiological circadian rhythm of melatonin and to avoid prolonged, supra-physiological blood levels.


Melatonin MeSH Core Body Temperature Melatonin Level Agomelatine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



No sources of funding were used to assist in the preparation of this review. The authors have no potential conflicts of interest that are directly relevant to the content of this review.


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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • Esmée M. S. Vural
    • 1
    • 3
    Email author
  • Barbara C. van Munster
    • 1
    • 2
  • Sophia E. de Rooij
    • 1
  1. 1.Department of Internal Medicine, Section of Geriatric Medicine, Academic Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands
  2. 2.Department of Geriatric MedicineGelre HospitalsApeldoornThe Netherlands
  3. 3.Vu Medical Center; 4A-35AmsterdamThe Netherlands

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