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Table 1 Characteristics of the RE-DUAL PCI population: proton pump inhibitor (PPI) vs no PPI at baseline

From: Dabigatran Dual Therapy vs Warfarin Triple Therapy Post-Percutaneous Coronary Intervention in Patients with Atrial Fibrillation With/Without a Proton Pump Inhibitor: A Pre-Specified Analysis of the RE-DUAL PCI Trial

  PPI at baseline, yes PPI at baseline, no
Total (n = 1641) Total (n = 1037)
Demographic data
 Age, mean (SD), years 71.0 (8.7) 70.4 (8.6)
 Male sex, n (%) 1220 (74.3) 813 (78.4)
 CrCl, mL/min, mean (SD)a 76.5 (29.5) 80.5 (29.3)
Medical and surgical history
 Prior MI, n (%) 458 (27.9) 229 (22.1)
 Prior CAD, n (%) 1096 (66.8) 701 (67.6)
 Prior PCI, n (%) 585 (35.6) 311 (30)
 LV ejection fraction,b mean (SD), % 50.6 (12.3) 51.7 (12.8)
 Heart failure, n (%) 570 (34.7) 350 (33.8)
 Diabetes mellitus, n (%) 615 (37.5) 358 (34.5)
 Hypertension, n (%) 912 (55.6) 479 (46.2)
 Currently smoking,cn (%) 214 (13.0) 120 (11.6)
 Previous GI bleeding, ulcerative GI disease, or gastritis, n (%) 135 (8.2) 44 (4.2)
 Prior major bleeding or predisposition to bleeding, n (%) 18 (1.1) 13 (1.3)
 CHA2DS2-VASc score, mean (SD) 3.7 (1.6) 3.5 (1.6)
 Modified HAS-BLED score, mean (SD) 2.7 (0.7) 2.7 (0.7)
In-hospital approach
 Indication for PCI: ACS, n (%) 875 (53.3) 478 (46.1)
 Radial access,dn (%) 1054 (64.2) 649 (62.6)
 Only one coronary stent,en (%) 1326 (80.8) 816 (78.7)
 Use of DES only,fn (%) 1367 (83.3) 843 (81.3)
 UFH use in index procedure, n (%) 1396 (85.1) 859 (82.8)
Baseline medications
 Clopidogrel, n (%) 1451 (88.4) 880 (84.9)
 Statins 1455 (88.7) 879 (84.8)
 Oral hypoglycemic drugs 430 (26.2) 255 (24.6)
 ACE inhibitors 912 (55.6) 497 (47.9)
 Angiotensin receptor blockers 535 (32.6) 334 (32.2)
 β-blockers 1387 (84.5) 844 (81.4)
  1. Note, 47 patients with missing information on PPI use at baseline are excluded
  2. ACE angiotensin converting enzyme, ACS acute coronary syndrome, CAD coronary artery disease, CrCl creatinine clearance, DES drug-eluting stent, GI gastrointestinal, LV left ventricular, MI myocardial infarction, PCI percutaneous coronary intervention, SD standard deviation, UFH unfractionated heparin
  3. aMissing in 221 patients
  4. bMissing in 183 patients
  5. cMissing in one patient
  6. dMissing in 20 patients
  7. eMissing in 50 patients
  8. fMissing in seven patients