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Drugs

, Volume 78, Issue 6, pp 643–673 | Cite as

Herbal Dietary Supplements for Erectile Dysfunction: A Systematic Review and Meta-Analysis

  • Francesca Borrelli
  • Cristiano Colalto
  • Domenico V. Delfino
  • Marcello Iriti
  • Angelo A. Izzo
Systematic Review

Abstract

Purpose

Erectile dysfunction (ED) is a common condition that significantly affects quality of life and interpersonal relationships.

Objective

Our objective was to perform a systematic review and meta-analysis to evaluate the efficacy of herbal dietary supplements in the treatment of ED.

Materials and Methods

We searched five databases to identify randomized controlled trials (RCTs) that evaluated the clinical efficacy of herbal medicines in ED. Quality was assessed and risk of bias was estimated using the Jadad score and the Cochrane risk-of-bias tool.

Results

In total, 24 RCTs, including 2080 patients with ED, were identified. Among these, 12 evaluated monopreparations (five ginseng [n = 399], three saffron [n = 397], two Tribulus terrestris [n = 202], and one each Pinus pinaster [n = 21] and Lepidium meyenii [n = 50]), seven evaluated formulations (n = 544), and five investigated dietary supplements in combination with pure compounds (n = 410). Ginseng significantly improved erectile function (International Index of Erectile Function [IIEF]-5 score: 140 ginseng, 96 placebo; standardized mean difference [SMD] 0.43; 95% confidence interval [CI] 0.15–0.70; P < 0.01; I2 = 0), P. pinaster and L. meyenii showed very preliminary positive results, and saffron and T. terrestris treatment produced mixed results. Several herbal formulations were associated with a decrease of IIEF-5 or IIEF-15, although the results were preliminary. The quality of the included studies varied, with only seven having a prevalent low risk of bias. The median methodological quality Jadad score was three out of a maximum of five. Adverse events were recorded in 19 of 24 trials, with no significant differences between placebo and verum in placebo-controlled studies.

Conclusions

Encouraging evidence suggests that ginseng may be an effective herbal treatment for ED. However, further, larger, and high-quality studies are required before firm conclusions can be drawn. Promising (although very preliminary) results have also been generated for some herbal formulations. Overall, more research in the field, adhering to the CONSORT statement extension for reporting trials, is justified before the use of herbal products in ED can be recommended.

Notes

Author Contributions

All authors collectively planned the study. FB and AAI drafted the systematic review manuscript. FB and AAI assessed the eligibility of included articles and extracted data. DD, MI, and CC assessed the quality of the studies. All authors served as adjudicators for disagreements. CC performed the meta-analysis. All authors reviewed the manuscript for intellectual content and approved the final version.

Compliance with Ethical Standards

Conflict of interest

Francesca Borrelli, Cristiano Colalto, Domenico V. Delfino, Marcello Iriti, and Angelo A. Izzo have no conflicts of interest that are directly relevant to the content of this manuscript.

Funding

No funding was received in the preparation of this systematic review.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Pharmacy, School of Medicine and SurgeryUniversity of Napes Federico IINaplesItaly
  2. 2.Farmacia San Paolo dr ColaltoSan Giovanni IlarioneItaly
  3. 3.Section of Pharmacology, Department of MedicineUniversity of PerugiaS. Andrea delle Fratte, PerugiaItaly
  4. 4.Department of Agricultural and Environmental SciencesMilan State UniversityMilanItaly
  5. 5.Working Group “Pharmacognosy and Phytotherapy” of the Italian Pharmacological SocietyMilanItaly

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