Drugs

, Volume 76, Issue 13, pp 1257–1270 | Cite as

Therapeutic Monoclonal Antibodies for the Treatment of Chronic Obstructive Pulmonary Disease

  • Maria Gabriella Matera
  • Clive Page
  • Paola Rogliani
  • Luigino Calzetta
  • Mario Cazzola
Review Article

Abstract

Chronic obstructive pulmonary disease (COPD) is a disorder characterized by a complex chronic inflammatory response that is largely poorly responsive to treatment with corticosteroids. Consequently, there is a huge need to find effective anti-inflammatory agents for the treatment of patients with this disease. Inhibition of cytokines and chemokines or their receptors using monoclonal antibodies (mAbs) could be a potential strategy to treat the inflammatory component of COPD. In this article, we review the therapeutic potential of some of these mAbs; however, to date there has been little or no therapeutic effect of any mAb directed against cytokines or chemokines in patients with COPD. This may reflect the complexity of COPD in which there is no dominant role for any single cytokine or chemokine. It is also likely that since the umbrella term COPD covers many endotypes having different underlying mechanisms, mAbs directed towards specific cytokines or chemokines should be tested in restricted and focused populations.

Notes

Compliance with Ethical Standards

Conflict of interest

Maria Gabriella Matera, Clive Page, Paola Rogliani, Luigino Calzetta and Mario Cazzola have no relevant affiliations or financial involvement with any organization or entity with a financial interest in, or financial conflict with, the subject matter or materials discussed in the manuscript, including employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Funding

This manuscript was not funded/sponsored, and no writing assistance was utilized in its production.

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Maria Gabriella Matera
    • 1
  • Clive Page
    • 2
  • Paola Rogliani
    • 3
  • Luigino Calzetta
    • 3
  • Mario Cazzola
    • 3
  1. 1.Department of Experimental MedicineSecond University of NaplesNaplesItaly
  2. 2.Sackler Institute of Pulmonary Pharmacology, King’s College LondonLondonUK
  3. 3.Department of Systems MedicineUniversity of Rome Tor VergataRomeItaly

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