, Volume 76, Issue 6, pp 639–646 | Cite as

The Emerging Role of PI3K Inhibitors in the Treatment of Hematological Malignancies: Preclinical Data and Clinical Progress to Date

  • Till Seiler
  • Grit Hutter
  • Martin Dreyling
Leading Article


The phosphoinositide 3-kinase (PI3K)/Akt/mTOR pathway is implicated in the pathogenesis of lymphoma. Deeper understanding of the diversity and biological impact of this pathway has led to the development of specific inhibitors to this pathway. Preclinical data in cell lines, patient samples and disease models have broadened our understanding of PI3K inhibition. Several PI3K inhibitors are currently in advanced stages of clinical development. Idelalisib is the first agent of this new substance class to be approved in chronic lymphocytic leukemia and follicular lymphoma. Other agents specifically target different PI3K isoforms and show promising clinical efficacy.


Chronic Lymphocytic Leukemia Follicular Lymphoma Mantle Cell Lymphoma Overall Response Rate PI3K Inhibitor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Compliance with Ethical Standards


No funding was provided to Till Seiler, Grit Hutter and Martin Dreyling for the preparation of this review.

Conflict of interest

Till Seiler, Grit Hutter and Martin Dreyling declare no conflict of interests with regard to this article.


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Department of Internal Medicine III, University Hospital GrosshadernLudwig Maximilians University (LMU)MunichGermany

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