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Optimizing the Use of Aspirin for Cardiovascular Prevention

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Abstract

This article describes the mechanism of action, pharmacokinetics, and pharmacodynamics of aspirin at doses used for cardiovascular prevention and provides specific management recommendations for optimal use in clinical practice. The paper highlights practical aspects related to antiplatelet therapy, including the optimal dose of aspirin, concomitant treatment with other NSAIDs, and strategies for the prevention of gastrointestinal toxicity. Specifically, we revise the benefits and hazards in different clinical settings to help the clinician in the decision-making process for individuals who have different risks for cardiovascular and gastrointestinal bleeding events.

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Acknowledgments

This study was funded by a grant for international research post-residency, Spanish Society of Cardiology (RC); B01 from the Regional Government of Aragón in Spain (AL).

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Authors and Affiliations

  1. Service of Digestive Diseases, University Hospital Lozano Blesa, University of Zaragoza, IIS Aragón, CIBERehd, Zaragoza, Spain

    Carlos Sostres & Angel Lanas

  2. Heart Rhythm Management Center, Cardiovascular Division, Cardiovascular Center, Free University of Brussels (UZ Brussels) VUB, Laarbeeklaan 101, Brussels, Belgium

    Rubén Casado-Arroyo

  3. Service of Cardiology, University Hospital Lozano Blesa, University of Zaragoza, IIS Aragon, CIBERehd, Zaragoza, Spain

    Rubén Casado-Arroyo

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  1. Rubén Casado-Arroyo
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  2. Carlos Sostres
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Correspondence to Rubén Casado-Arroyo.

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Casado-Arroyo, R., Sostres, C. & Lanas, A. Optimizing the Use of Aspirin for Cardiovascular Prevention. Drugs 73, 803–814 (2013). https://doi.org/10.1007/s40265-013-0061-z

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