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Comment on: "Should Antidepressants be Avoided in Pregnancy?"

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A Correction to this article was published on 16 May 2023

A Letter to the Editor to this article was published on 27 April 2023

The Original Article was published on 20 December 2022

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References

  1. Besag FMC, Vasey MJ. Should antidepressants be avoided in pregnancy? Drug Saf. 2023;46:1–17.

    Article  CAS  PubMed  Google Scholar 

  2. Anderson KN, Lind JN, Simeone RM, et al. Maternal use of specific antidepressant medications during early pregnancy and the risk of selected birth defects. JAMA Psychiatry. 2020;77:1246–55.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Kolding L, Ehrenstein V, Pedersen L, et al. Antidepressant use in pregnancy and severe cardiac malformations: Danish register-based study. BJOG. 2021;128:1949–57.

    Article  CAS  PubMed  Google Scholar 

  4. Palmsten K, Chambers CD, Wells A, Bandoli G. Patterns of prenatal antidepressant exposure and risk of preeclampsia and postpartum haemorrhage. Paediatr Perinat Epidemiol. 2020;34:597–606.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Bandoli G, Chambers CD, Wells A, Palmsten K. Prenatal antidepressant use and risk of adverse neonatal outcomes. Pediatrics. 2020;146: e20192493.

    Article  PubMed  Google Scholar 

  6. Hoyer D. Targeting the 5-HT system: potential side effects. Neuropharmacology. 2020;179: 108233.

    Article  CAS  PubMed  Google Scholar 

  7. Cabrera RM, Linda Lin Y, Law E, Kim J, Wlodarczyk BJ. The teratogenic effects of sertraline in mice. Birth Defects Res. 2020;112:1014–24.

    Article  CAS  PubMed  Google Scholar 

  8. Warkus ELL, Marikawa Y. Fluoxetine inhibits canonical Wnt signaling to impair embryoid body morphogenesis: potential teratogenic mechanisms of a commonly used antidepressant. Toxicol Sci. 2018;165:372–88.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Liao CC, Lee LJ. Neonatal fluoxetine exposure affects the action potential properties and dendritic development in cortical subplate neurons of rats. Toxicol Lett. 2011;207:314–21.

    Article  CAS  PubMed  Google Scholar 

  10. Lugo-Candelas C, Cha J, Hong S, et al. Associations between brain structure and connectivity in infants and exposure to selective serotonin reuptake inhibitors during pregnancy. JAMA Pediatr. 2018;172:525–33.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Christensen J, Trabjerg BB, Sun Y, Dreier JW. Association of maternal antidepressant prescription during pregnancy with standardized test scores of Danish school-aged children. JAMA. 2021;326:1725–35.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Braillon A. Association of maternal antidepressant prescription during pregnancy and Danish school-aged children’s standardized test scores. JAMA. 2022;327:781–2.

    Article  PubMed  Google Scholar 

  13. Amick HR, Gartlehner G, Gaynes BN, et al. Comparative benefits and harms of second generation antidepressants and cognitive behavioral therapies in initial treatment of major depressive disorder: systematic review and meta-analysis. BMJ. 2015;351: h6019.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Munkholm K, Paludan-Müller AS, Boesen K. Considering the methodological limitations in the evidence base of antidepressants for depression: a reanalysis of a network meta-analysis. BMJ Open. 2019;9: e024886.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Leichsenring F, Steinert C, Rabung S, Ioannidis JPA. The efficacy of psychotherapies and pharmacotherapies for mental disorders in adults: an umbrella review and meta-analytic evaluation of recent meta-analyses. World Psychiatry. 2022;21:133–45. https://doi.org/10.1002/wps.2094.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Kolovos S, Kleiboer A, Cuijpers P. Effect of psychotherapy for depression on quality of life: meta-analysis. Br J Psychiatry. 2016;209:460–8.

    Article  PubMed  Google Scholar 

  17. Stone MB, Yaseen ZS, Miller BJ, Richardville K, Kalaria SN, Kirsch I. Response to acute monotherapy for major depressive disorder in randomized, placebo controlled trials submitted to the US Food and Drug Administration: individual participant data analysis. BMJ. 2022;378: e067606.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Besag FM, Dodd S. When can a drug be declared “safe”? Curr Drug Saf. 2010;5:112–3.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

Authors

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Correspondence to Alain Braillon.

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Conflict of interest

Alain Braillon, Susan Bewley and Florian Naudet are among in industry-independent experts from Jeanne Lenzer’s list (https://jeannelenzer.com/list-independent-experts). SB’s declaration of interests can be found at whopaysthisdoctor.

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Availability of data and material

Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.

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Authors’ contribution

Alain Braillon, Susan Bewley, Aubrey Blumsohn, and Florian Naudet have been exchanging about this topic. Alain Braillon wrote a first draft. All authors have reviewed and approved the final version.

Additional information

The original online version of this article was revised. Author affiliation and consent for publication are corrected in the original article.

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Braillon, A., Bewley, S., Blumsohn, A. et al. Comment on: "Should Antidepressants be Avoided in Pregnancy?". Drug Saf 46, 615–616 (2023). https://doi.org/10.1007/s40264-023-01308-1

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  • DOI: https://doi.org/10.1007/s40264-023-01308-1

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