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Fluoroquinolone-Induced Photosensitivity: A Chemical Fragment-Based Approach by a Case/Non-case Study in VigiBase®

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Abstract

Introduction

Fluoroquinolones are widely used to treat bacterial infections. Many in vitro and in vivo studies have established a chemical relationship between fluoroquinolones’ particular chemical structure and photosensitivity. The aim of this study was to establish a relationship between the chemical structure of fluoroquinolones and the risk of photosensitivity adverse effects from real-world data.

Methods

All the Individual Case Safety Reports (ICSRs) related to fluoroquinolones and registered in the World Health Organization global database (VigiBase®) up to December 31, 2017 were collected. A disproportionality analysis was performed in order to quantify the photosensitivity risk for each fluoroquinolone by calculating their reporting odds ratio (ROR).

Results

Up to December 31, 2017, 282,805 ICSRs related to fluoroquinolones were selected, of which 1647 were photosensitivity adverse event cases. Sparfloxacin had the highest adjusted ROR of 161.10 (95% confidence interval [CI] 133.66–194.02) followed by grepafloxacin (40.30 [26.30–59.60]) closely followed by lomefloxacin (32.61 [28.61–37.07]), then enoxacin (11.04 [8.33–14.32]) and fleroxacin (8.22 [5.06–12.56]).

Conclusion

This study confirms the high reporting rate of photosensitivity adverse effects for sparfloxacin from real-world data. Moreover, our data suggest more photosensitivity adverse effects reporting for fluoroquinolones with a halogen at their 8th position.

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Authors and Affiliations

  1. Service de Pharmacologie Médicale et Clinique, Centre Régional de Pharmacovigilance, Centre Hospitalier Universitaire de Toulouse, Toulouse, France

    Yoann Zelmat, Vanessa Rousseau, Leila Chebane, Jean-Louis Montastruc, Haleh Bagheri & Agnès Sommet

  2. Centre d’Investigation Clinique 1436, Centre Hospitalier Universitaire de Toulouse, Toulouse, France

    Vanessa Rousseau, Jean-Louis Montastruc, Haleh Bagheri & Agnès Sommet

  3. UMR 1027, INSERM, Faculté de Médecine, Université Paul Sabatier, Toulouse, France

    Jean-Louis Montastruc, Haleh Bagheri & Agnès Sommet

Authors
  1. Yoann Zelmat
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  2. Vanessa Rousseau
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  3. Leila Chebane
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  4. Jean-Louis Montastruc
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  5. Haleh Bagheri
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  6. Agnès Sommet
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Corresponding author

Correspondence to Yoann Zelmat.

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Conflict of interest

Yoann Zelmat, Vanessa Rousseau, Leila Chebane, Jean-Louis Montastruc, Haleh Bagheri, and Agnès Sommet have no conflicts of interest that are directly relevant to the content of this study.

Funding

No sources of funding were used to assist in the preparation of this study.

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Zelmat, Y., Rousseau, V., Chebane, L. et al. Fluoroquinolone-Induced Photosensitivity: A Chemical Fragment-Based Approach by a Case/Non-case Study in VigiBase®. Drug Saf 43, 561–566 (2020). https://doi.org/10.1007/s40264-020-00917-4

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  • DOI: https://doi.org/10.1007/s40264-020-00917-4

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