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Table 4 Effects of specific nonantibiotic drugs on rates of multiple drug intolerance

From: Multiple Drug Intolerance Syndrome: A Large-Scale Retrospective Study

Drug class Multiple drug intolerance p value
No Yes
ACEi <0.001*
 No (N = 25,277) 24,133 (95.5 %) 1,144 (4.5 %)  
 Yes (N = 418) 312 (74.6 %) 106 (25.4 %)  
Antihistamines <0.001*
 No (N = 25,296) 24,125 (95.4 %) 1,171 (4.6 %)  
 Yes (N = 399) 320 (80.2 %) 79 (19.8 %)  
Aspirin <0.001*
 No (N = 23,198) 22,210 (95.7 %) 988 (4.3 %)  
 Yes (N = 2,497) 2,235 (89.5 %) 262 (10.5 %)  
Latex <0.001*
 No (N = 25,203) 24,013 (95.3 %) 1,190 (4.7 %)  
 Yes (N = 492) 432 (87.8 %) 60 (12.2 %)  
Lipid regulators <0.001*
 No (N = 25,356) 24,180 (95.4 %) 1,176 (4.6 %)  
 Yes (N = 339) 265 (78.2 %) 74 (21.8 %)  
NSAIDs <0.001*
 No (N = 24,143) 23,177 (96 %) 966 (4 %)  
 Yes (N = 1,552) 1,268 (81.7 %) 284 (18.3 %)  
Opioids <0.001*
 No (N = 22,531) 21,719 (96.4 %) 812 (3.6 %)  
 Yes (N = 3,164) 2,726 (86.2 %) 438 (13.8 %)  
Paracetamol <0.001*
 No (N = 25,424) 24,225 (95.3 %) 1,199 (4.7 %)  
 Yes (N = 271) 220 (81.2 %) 51 (18.8 %)  
Peanuts <0.001*
 No (N = 25,427) 24,205 (95.2 %) 1,222 (4.8 %)  
 Yes (N = 268) 240 (89.6 %) 28 (10.4 %)  
Shellfish <0.001*
 No (N = 25,404) 24,184 (95.2 %) 1,220 (4.8 %)  
 Yes (N = 291) 261 (89.7 %) 30 (10.3 %)  
Other nonantibiotics <0.001*
 No (N = 22,106) 21,504 (97.3 %) 602 (2.7 %)  
 Yes (N = 3,589) 2,941 (81.9 %) 648 (18.1 %)  
  1. Categorical data reported as: n (%), with p value from Fisher’s exact test
  2. * Significant at p < 0.05