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Table 3 Effects of selected drugs and comorbidities on rates of multiple drug intolerance

From: Multiple Drug Intolerance Syndrome: A Large-Scale Retrospective Study

Factor Multiple drug intolerance p value Multivariable odds ratioa (95 % CI) p value
No Yes
Antihistamine prescribed <0.001*   <0.001*
 No (N = 21,846) 20,945 (95.9 %) 901 (4.1 %)  
 Yes (N = 3,849) 3,500 (90.9 %) 349 (9.1 %)   1.86 (1.59–2.17) <0.001*
EpiPen prescribed 0.002*   0.046*
 No (N = 25,647) 24,405 (95.2 %) 1,242 (4.8 %)  
 Yes (N = 48) 40 (83.3 %) 8 (16.7 %)   2.36 (1.02–5.46) 0.046*
Prednisolone prescribed <0.001*   0.014*
 No (N = 22,461) 21,464 (95.6 %) 997 (4.4 %)  
 Yes (N = 3,234) 2,981 (92.2 %) 253 (7.8 %)   1.25 (1.05–1.49) 0.014*
Hydrocortisone prescribed <0.001*   0.628
 No (N = 23,691) 22,609 (95.4 %) 1,082 (4.6 %)  
 Yes (N = 2,004) 1,836 (91.6 %) 168 (8.4 %)   1.05 (0.85–1.31) 0.628
Psychological comorbidity 0.951   0.589
 No (N = 24,594) 23,398 (95.1 %) 1,196 (4.9 %)  
 Yes (N = 1,101) 1,047 (95.1 %) 54 (4.9 %)   0.91 (0.65–1.28) 0.589
Atopic comorbidity 0.444   0.903
 No (N = 23,050) 21,920 (95.1 %) 1,130 (4.9 %)  
 Yes (N = 2,645) 2,525 (95.5 %) 120 (4.5 %)   1.01 (0.81–1.26) 0.903
  1. Categorical data reported as: n (%), with p value from Fisher’s exact test
  2. * Significant at p < 0.05
  3. aFrom multivariable binary logistic regression, adjusting for all factors in Tables 1 and 2