Fig. 5

Prediction-corrected and variability-corrected visual predictive checks in a pediatric B-cell precursor acute lymphoblastic leukemia population. Black circles represent the observed data. The black lines show the median (solid) and the 10th and 90th percentiles (dash) of the observed data. The shaded regions show the 95% confidence interval of the median (red) and the 10th and 90th percentiles (blue) of the simulated concentration (N = 1000). hrs hours