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Fig. 1 | Clinical Pharmacokinetics

Fig. 1

From: Population Pharmacokinetics of Inotuzumab Ozogamicin in Pediatric Relapsed/Refractory B-Cell Precursor Acute Lymphoblastic Leukemia: Results of Study ITCC-059

Fig. 1

Inotuzumab ozogamicin pharmacokinetic model structure. Total clearance (CLtotal) is the sum of linear clearance (CL1) and time-dependent clearance (CLt). CL2 initial value of time-dependent clearance, IV intravenous, kdes decay coefficient, Q intercompartment clearance, V1 volume of distribution in the central compartment, V2 volume of distribution in the peripheral compartment

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