Skip to main content
Log in

Comment on “Pharmacology, Pharmacokinetics and Pharmacodynamics of Eculizumab, and Possibilities for an Individualized Approach to Eculizumab”

  • Letter to the Editor
  • Published:
Clinical Pharmacokinetics Aims and scope Submit manuscript

A Letter to the Editor to this article was published on 28 October 2020

The Original Article was published on 13 February 2019

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  1. Wijnsma KL, Ter Heine R, Moes DJAR, et al. Pharmacology, pharmacokinetics and pharmacodynamics of eculizumab, and possibilities for an individualized approach to eculizumab. Clin Pharmacokinet. 2019;58(7):859–74. https://doi.org/10.1007/s40262-019-00742-8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Soliris® (eculizumab) US Prescribing Information. October 2017. Reference ID 4171013. Available online from https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/125166s422lbl.pdf. Accessed 21 Oct 2020.

  3. Duval A, Olagne J, Cognard N, et al. Pregnancy in a kidney transplant woman under treatment with eculizumab for atypical hemolytic uremic syndrome: is it safe? Kidney Int Rep. 2019;4(5):733–9. https://doi.org/10.1016/j.ekir.2018.12.014.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Sharma R, Keyzner A, Liu J, Bradley T, Allen SL. Successful pregnancy outcome in paroxysmal nocturnal hemoglobinuria (PNH) following escalated eculizumab dosing to control breakthrough hemolysis. Leuk Res Rep. 2015;4(1):36–8. https://doi.org/10.1016/j.lrr.2015.05.001.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Ricklin D, Barratt-Due A, Mollnes TE. Complement in clinical medicine: clinical trials, case reports and therapy monitoring. Mol Immunol. 2017;89:10–21. https://doi.org/10.1016/j.molimm.2017.05.013.

    Article  CAS  PubMed  Google Scholar 

  6. Kelly RJ, Höchsmann B, Szer J, et al. Eculizumab in pregnant patients with paroxysmal nocturnal hemoglobinuria. N Engl J Med. 2015;373(11):1032–9. https://doi.org/10.1056/NEJMoa1502950.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Andrew Siedlecki.

Ethics declarations

Conflict of Interest

There are no conflicts of interest reported for any of the co-authors.

Funding

There was no funding source associated with this study.

Ethics Approval

The study was approved by Mass General Brigham Institutional Review Board (IRB).

Consent to Participate

Subjects were enrolled after an informed consent form (ICF) was explained and signed by them at their free will. The ICF was approved by the Mass General Brigham IRB.

Consent for Publication

All authors have consented to the publication of data.

Availability of Data and Material

Data is available on request.

Code Availability

There is no computer code associated with this study.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (PDF 308 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Liu, J., Memon, A.A., Lyu, L. et al. Comment on “Pharmacology, Pharmacokinetics and Pharmacodynamics of Eculizumab, and Possibilities for an Individualized Approach to Eculizumab”. Clin Pharmacokinet 59, 1641–1643 (2020). https://doi.org/10.1007/s40262-020-00950-7

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40262-020-00950-7

Navigation