Dear Reader,

As we reach the final issue of Clinical Pharmacokinetics for 2019, we wish to reflect on another successful year’s achievements, and to thank all those who have contributed their time and effort to guarantee the high quality of our content.


2019 was a successful year for Clinical Pharmacokinetics. A total 119 articles have been published; the most popular of these, in terms of downloads from SpringerLink, have been:

  • Concordet D, Gandia P, Montastruc JL, Bousquet-Mélou A, Lees P, Ferran A, Toutain PL. Levothyrox® New and Old Formulations: Are they Switchable for Millions of Patients? Clin Pharmacokinet. 2019 Jul;58(7):827–833. https://doi.org/10.1007/S40262-019-00747-3

  • Miller NA, Reddy MB, Heikkinen AT, Lukacova V, Parrott N. Physiologically Based Pharmacokinetic Modelling for First-In-Human Predictions: An Updated Model Building Strategy Illustrated with Challenging Industry Case Studies. Clin Pharmacokinet. 2019 Jun;58(6):727–746. https://doi.org/10.1007/S40262-019-00741-9

  • Centanni M, Moes DJAR, Trocóniz IF, Ciccolini J, van Hasselt JGC. Clinical Pharmacokinetics and Pharmacodynamics of Immune Checkpoint Inhibitors. Clin Pharmacokinet. 2019 Jul;58(7):835–857. https://doi.org/10.1007/S40262-019-00748-2

  • Kinnunen M, Piirainen P, Kokki H, Lammi P, Kokki M. Updated Clinical Pharmacokinetics and Pharmacodynamics of Oxycodone. Clin Pharmacokinet. 2019 Jun;58(6):705–725. https://doi.org/10.1007/S40262-018-00731-3

  • Granhall C, Donsmark M, Blicher TM, Golor G, Søndergaard FL, Thomsen M, Bækdal TA. Safety and Pharmacokinetics of Single and Multiple Ascending Doses of the Novel Oral Human GLP-1 Analogue, Oral Semaglutide, in Healthy Subjects and Subjects with Type 2 Diabetes. Clin Pharmacokinet. 2019 Jun;58(6):781–791. https://doi.org/10.1007/S40262-018-0728-4

  • Smolders EJ, Ter Horst PJG, Wolters S, Burger DM. Cardiovascular Risk Management and Hepatitis C: Combining Drugs. Clin Pharmacokinet. 2019 May;58(5):565-592. https://doi.org/10.1007/S40262-018-0710-1

  • Byon W, Garonzik S, Boyd RA, Frost CE. Apixaban: A Clinical Pharmacokinetic and Pharmacodynamic Review. Clin Pharmacokinet. 2019 Oct;58(10):1265–1279. https://doi.org/10.1007/S40262-019-00775-Z

  • Colin PJ, Allegaert K, Thomson AH, Touw DJ, Dolton M, de Hoog M, Roberts JA, Adane ED, Yamamoto M, Santos-Buelga D, Martín-Suarez A, Simon N, Taccone FS, Lo YL, Barcia E, Struys MMRF, Eleveld DJ. Vancomycin Pharmacokinetics Throughout Life: Results from a Pooled Population Analysis and Evaluation of Current Dosing Recommendations. Clin Pharmacokinet. 2019 Jun;58(6):767–780. https://doi.org/10.1007/S40262-018-0727-5

  • Wijnsma KL, Ter Heine R, Moes DJAR, Langemeijer S, Schols SEM, Volokhina EB, van den Heuvel LP, Wetzels JFM, van de Kar NCAJ, Brüggemann RJ. Pharmacology, Pharmacokinetics and Pharmacodynamics of Eculizumab, and Possibilities for an Individualized Approach to Eculizumab. Clin Pharmacokinet. 2019 Jul;58(7):859–874. https://doi.org/10.1007/S40262-019-00742-8

  • Bækdal TA, Borregaard J, Hansen CW, Thomsen M, Anderson TW. Effect of Oral Semaglutide on the Pharmacokinetics of Lisinopril, Warfarin, Digoxin, and Metformin in Healthy Subjects. Clin Pharmacokinet. 2019 Sep;58(9):1193–1203. https://doi.org/10.1007/S40262-019-00756-2

Social media sharing of information has become important and is another metric with which to measure the reach of articles. This year the following articles published in Clinical Pharmacokinetics scored highly on the Altmetric system:

  • Concordet D, Gandia P, Montastruc JL, Bousquet-Mélou A, Lees P, Ferran A, Toutain PL. Levothyrox® New and Old Formulations: Are they Switchable for Millions of Patients? Clin Pharmacokinet. 2019 Jul;58(7):827–833. https://doi.org/10.1007/S40262-019-00747-3

  • Hauser RA, Pahwa R, Wargin WA, Souza-Prien CJ, McClure N, Johnson R, Nguyen JT, Patni R, Went GT. Pharmacokinetics of ADS-5102 (Amantadine) Extended Release Capsules Administered Once Daily at Bedtime for the Treatment of Dyskinesia. Clin Pharmacokinet. 2019 Jan;58(1):77–88. https://doi.org/10.1007/s40262-018-0663-4

  • Groenland SL, van Nuland M, Verheijen RB, Schellens JHM, Beijnen JH, Huitema ADR, Steeghs N. Therapeutic Drug Monitoring of Oral Anti-Hormonal Drugs in Oncology. Clin Pharmacokinet. 2019 Mar;58(3):299-308. https://doi.org/10.1007/s40262-018-0683-0

  • Daskapan A, Idrus LR, Postma MJ, Wilffert B, Kosterink JGW, Stienstra Y, Touw DJ, Andersen AB, Bekker A, Denti P, Hemanth Kumar AK, Jeremiah K, Kwara A, McIlleron H, Meintjes G, van Oosterhout JJ, Ramachandran G, Rockwood N, Wilkinson RJ, van der Werf TS, Alffenaar JC. A Systematic Review on the Effect of HIV Infection on the Pharmacokinetics of First-Line Tuberculosis Drugs. Clin Pharmacokinet. 2019 Jun;58(6):747–766. https://doi.org/10.1007/s40262-018-0716-8

  • Ternant D, Azzopardi N, Raoul W, Bejan-Angoulvant T, Paintaud G. Influence of Antigen Mass on the Pharmacokinetics of Therapeutic Antibodies in Humans. Clin Pharmacokinet. 2019 Feb;58(2):169-187. https://doi.org/10.1007/s40262-018-0680-3

  • Tan CRC, Abdul-Majeed S, Cael B, Barta SK. Clinical Pharmacokinetics and Pharmacodynamics of Bortezomib. Clin Pharmacokinet. 2019 Feb;58(2):157-168. https://doi.org/10.1007/s40262-018-0679-9

  • Centanni M, Moes DJAR, Trocóniz IF, Ciccolini J, van Hasselt JGC. Clinical Pharmacokinetics and Pharmacodynamics of Immune Checkpoint Inhibitors. Clin Pharmacokinet. 2019 Jul;58(7):835–857. https://doi.org/10.1007/s40262-019-00748-2

  • Bulitta JB, Jiao Y, Drescher SK, Oliver A, Louie A, Moya B, Tao X, Wittau M, Tsuji BT, Zavascki AP, Shin BS, Drusano GL, Sörgel F, Landersdorfer CB. Four Decades of β-Lactam Antibiotic Pharmacokinetics in Cystic Fibrosis. Clin Pharmacokinet. 2019 Feb;58(2):143–156. https://doi.org/10.1007/s40262-018-0678-x

  • Salem AH, Dave N, Marbury T, Hu B, Miles D, Agarwal SK, Bueno OF, Menon RM. Pharmacokinetics of the BCL-2 Inhibitor Venetoclax in Subjects with Hepatic Impairment. Clin Pharmacokinet. 2019 Aug;58(8):1091–1100. https://doi.org/10.1007/s40262-019-00746-4

  • Hermann R, Karlsson MO, Novakovic AM, Terranova N, Fluck M, Munafo A. The Clinical Pharmacology of Cladribine Tablets for the Treatment of Relapsing Multiple Sclerosis. Clin Pharmacokinet. 2019 Mar;58(3):283–297. https://doi.org/10.1007/s40262-018-0695-9

The quality of articles published in the journal is also reflected in its most recent impact factor of 4.680. Clinical Pharmacokinetics is now ranked 30/267 journals in the ‘Pharmacology & Pharmacy’ category [Clarivate Analytics]. The Journal’s 2018 CiteScore is 4.33, with a ranking of 18/232 journals in the ‘Pharmacology [Medical]’ category [Scopus].


We thank the authors who have contributed articles to Clinical Pharmacokinetics over the course of 2019. The skill and dedication of all authors are critical to the continued publication of the journal. The quality of published articles is also testament to the significant efforts of the peer reviewers, whose commitment ensures that the journal’s content is held to the highest possible standard. We would like to thank the following individuals who acted as reviewers for Clinical Pharmacokinetics in the last 12 months:


Francisco Abad-Santos, Spain

Nurul Azrin Abd Rahman, Australia

Chiara Adembri, Italy

Jan-Willem C. Alffenaar, Australia

Hesham S. Al-Sallami, New Zealand

Wataru Ando, Japan

Anders Åsberg, Norway

Kyun S. Bae, Republic of Korea

Jacquelyn L. Bainbridge, USA

Matthew Barth, USA

Agnieszka Bienert, Poland

Sander Bins, The Netherlands

Geremia B. Bolli, Italy

Jeannet Bos, The Netherlands

Prithviraj Bose, USA

John Bradely, USA

William Bradley, USA

Elizabeth Burgener, USA

Howard A. Burris, USA

Yoseph Caraco, Israel

Dario Cattaneo, Italy

Di Chen, China

Manoranjenni Chetty, UK

Leena Choi, USA

Jeffrey J. Cies, USA

Marjon Cnossen, The Netherlands

Pier G. Cojutti, Italy

Angela P.H. Colbers, The Netherlands

Pieter Colin, The Netherlands

Jonathan Constance, USA

Camille Couffignal, France

Perrine Courlet, Switzerland

Stacy Croteau, USA

Muriel Cuendet, Switzerland

Burke Cunha, USA

Youssef Daali, Switzerland

Dorota Danielak, Poland

Kim Dao, Switzerland

Adam Darwich, Sweden

Dinesh de Alwis, USA

Wilfried de Backer, Belgium

Luc De Baerdemaeker, Belgium

Amparo de la Peña, USA

Rafael de la Torre, Spain

Jose de Leon, USA

Aurelia H. de Vries Schultink, The Netherlands

Jeroen Diepstraten, The Netherlands

Jasper Dingemanse, Switzerland

Zoubir Djerada, France

Tan N. Doan, Australia

Kevin J. Downes, USA

Julie B. Dumond, USA

Jeroen Elassaiss-Schaap, The Netherlands

Douglas J. Eleveld, The Netherlands

Maurizio Elia, Italy

Mats Enlund, Sweden

Steven R. Feldman, USA

Veronique Fremeaux, France

Freddy Frost, UK

Ken I. Fujita, Japan

Tsuyoshi Fukuda, USA

Masahide Fukudo, Japan

Eva Germovsek, Sweden

Paul Glue, New Zealand

Daniel Gonzalez, USA

Verena Gotta, Switzerland

Sylvain Goutelle, France

David J. Greenblatt, USA

Rick Greupink, The Netherlands

Morag Griffin, UK

Jeremie Guedj, France

Neeraj Gupta, USA

Andrea Hahn, USA

David M. G. Halpin, UK

R. Donald Harvey, USA

Hiddo J. L. Heerspink, The Netherlands

Nina Heldring, Sweden

James V. Hennessey, USA

Dennis A. Hesselink, The Netherlands

Akihiro Hisaka, Japan

Christoph P. Hornik, USA

Chuanpu Hu, USA

Marilyn A. Huestis, USA

Alwin D. R. Huitema, The Netherlands

Paul R. Hutson, USA

Margarita Inavova, USA

Diana Isaacs, USA

Masoud Jamei, UK

Zheng Jiao, China

Markus Joerger, Switzerland

Cecilie Johannessen Landmark, Norway

Siv Jonsson, Sweden

Vincent Jullien, France

Amal Kaddoumi, USA

Ron Keizer, Sweden

Edward Kerwin, USA

Peter J. Kilford, UK

Mark Kirstein, USA

Tomoo Kishaba, Japan

Frank Kloprogge, UK

Franziska Kluwe, Germany

Birgit Koch, The Netherlands

Gilbert Koch, Switzerland

Jean Koff, USA

Jill Kolesar, USA

Stephan Kraehenbuehl, Switzerland

Lisanne L. Krens, The Netherlands

Sriram Krishnaswami, USA

Jacek Kubica, Poland

José M. Lanao, Spain

Félicien Le Louedec, France

Chooi Y. Lee, Malaysia

Benedicte Lelièvre, France

Hendrikus J. M. Lemmens, USA

Linzhong Li, USA

Rafael Linden, Brazil

Zhijia Liu, China

Célia Lloret-Linares, France

Janel Long-Boyle, USA

Rubin Lubomirov, Spain

Cecile Magis-Escurra, The Netherlands

Anil R. Maharaj, USA

Iftekhar Mahmood, USA

Sherif H. Mahmoud, Canada

Michael Malfatti, USA

Rebecca Marsh, USA

Amélie Marsot, Canada

Joanna C. Masters, USA

Maria G. Matera, Italy

Ron A. A. Mathot, The Netherlands

Kazuaki Matsumoto, Japan

Calvin J. Meaney, USA

Sven Mensing, Germany

Robin Michelet, Germany

Neil A. Miller, UK

Iris Minichmayr, Sweden

Tomoyuki Mizuno, USA

Brady S. Moffett, USA

Massimo Morfini, Italy

Sunder Mudaliar, USA

Hussain Mulla, UK

Barbara Mulloy, UK

Mwila Mulubwa, South Africa

Ahmed Nader, USA

Florence Namour, France

Christa E. Nath, Australia

Michael N. Neely, USA

Salin Nhean, USA

Silpa Nuthalapati, USA

Shinju Obara, Japan

Marek Ochowiak, Poland

Eziafa I. Oduah, USA

Kayode Ogungbenro, UK

Melih Onay, Turkey

Ahmed A. Othman, USA

Mehdi Oualha, France

Daniele Ouellet, USA

Roberto Padrini, Italy

Amit Pai, USA

Amy B. Pai, USA

Manjunath P. Pai, USA

Hitesh Pandya, UK

John C. Panetta, USA

Sarah Parker, USA

Zinnia P. Parra-Guillén, Spain

Jignesh P. Patel, UK

Michael Paulzen, Germany

Sarah Perelli, Italy

Sheila A. Peters, Germany

Antoine Petitcollin, France

Mitch A. Phelps, USA

Italo Poggesi, Belgium

Thomas M. Polasek, Australia

Akshanth R. Polepally, USA

Richard A. Preston, USA

Alessio Provenzani, Italy

Indranil R. Rao, UK

Florence Raynaud, UK

Venkatesh Pilla Reddy, UK

Suzanne Reeves, UK

Brad Reisfeld, USA

David M. Reith, New Zealand

Lutz Renders, Germany

Ida Robertsen, Norway

Alicia Rodriguez-Gascon, Spain

Claire Roger, France

Michał Romański, Poland

Christopher M. Rubino, USA

Rovina Ruslami, Indonesia

Teijo I. Saari, Finland

Marko Sahinovic, The Netherlands

Mohammad Saleh, Jordan

Carlos G. Santos-Gallego, USA

Antonin Schmitt, France

Georgios Schoretsanitis, Switzerland

Josefine Schulz, Germany

Ute I. Schwarz, Canada

Naveed Shaik, USA

Marco Siccardi, UK

Werner Siegmund, Germany

Juergen Siekmann, Austria

Virginie Siguret, France

Alena Simalatsar, Switzerland

Fekade Sime, Australia

Ian Sinha, UK

Erik Sjogren, Sweden

Judith Smith, USA

Joanna Sobiak, Poland

Jin Woo Song, Republic of Korea

Ofer Spiegelstein, Israel

Edoardo Spina, Italy

Anand Srinivasan, India

Christine E. Staatz, Australia

Joseph F. Standing, UK

David Stepensky, Israel

Christophe P. Stove, Belgium

Michel M. R. F. Struys, The Netherlands

Albert Suttle, USA

Veronica Swystun, Canada

Mariko Takeda-Morishita, Japan

Rob ter Heine, The Netherlands

David Ternant, France

Torbjörn Tomson, Sweden

Aleksi Tornio, Finland

Pierre L. Toutain, France

Iñaki F. Troconiz, Spain

Alice Tseng, Canada

Nielka van Erp, The Netherlands

Anne van Rongen, The Netherlands

Jurgen Venitz, USA

Alexander A. Vinks, USA

Mark S. Wainwright, USA

Madeline Waldron, USA

Xinting Wang, China

Larissa Wenning, USA

Sebastian G. Wicha, Germany

Brian A. Willis, USA

Jean B. Woillard, France

Harvey Wong, Canada

Christine Xu, USA

Xinning Yang, USA

Ikuko Yano, Japan

Yanke Yu, USA

Markus Zeitlinger, Austria

Liang Zhao, USA

Songmao Zheng, USA

Tong Zhu, USA

Victoria C. Ziesenitz, Switzerland


In addition, we would like to thank the members of the journal’s Honorary Editorial Board, who have acted as peer reviewers and authors, and have provided guidance on journal content, policy and processes:


Fatemeh Akhlaghi, University of Rhode Island, Kingston, RI, USA

Karel M. Allegaert, University of Leuven, Leuven, Belgium

Gail D. Anderson, University of Washington, Seattle, WA, USA

Jos H. Beijnen, Utrecht University, Amsterdam, The Netherlands

Hans R. Brunner, University of Lausanne, Lausanne, Switzerland

Etienne Chatelut, Institut Universitaire du Cancer Toulouse, Toulouse, France

Mei-Ling Chen, Food and Drug Administration, Silver Spring, MD, USA

Stephen J. Clarke, Royal North Shore Hospital, Sydney, NSW, Australia

Jennifer L. Clements, Presbyterian College School of Pharmacy, Clinton, SC, USA

Maria L. Dahl, Karolinska Institutet, Uppsala, Sweden

Neal M. Davies, University of Alberta, Edmonton, AB, Canada

Hartmut Derendorf, University of Florida, Gainesville, FL, USA

C. Lindsay DeVane, Medical University of South Carolina, Charleston, SC, USA

Saskia N. de Wildt, Radboud University, Nijmegen, The Netherlands

Thomas C. Dowling, Ferris State University, Grand Rapids, MI, USA

Stephen B. Dufull, University of Otago, Dunedin, New Zealand

Chin B. Eap, Hopital de Cery, Lausanne, Switzerland

Hitoshi Echizen, Meiji Pharmaceutical University, Tokyo, Japan

Andrea N. Edginton, University of Waterloo, Waterloo, ON, Canada

Erik Eliasson, Karolinska University Hospital, Stockholm, Sweden

Albert Ferro, King’s College London, London, UK

Bruce Green, University of Queensland, Brisbane, QLD, Australia

Sam Harirforoosh, East Tennessee State University, Johnson City, TN, USA

Georg Hempel, Wilhelms-Universität Munster, Muster, Germany

Roger W. Jellife, University of Southern California, Los Angeles, CA, USA

Charlotte Kloft, Freie Universitaet Berlin, Berlin, Germany

Catherijne A. J. Knibbe, Leiden University, Leiden, The Netherlands

Jörn Lötsch, Johann Wolfgang Goethe-University, Frankfurt, Germany

Bernd Meibohm, University of Tennessee, Memphis, TN, USA

France Mentré, Universite Paris Diderot, Paris, France

Gerd Mikus, University of Heidelberg, Heidelberg, Germany

Gene D. Morse, University of Buffalo, Buffalo, NY, USA

Pertti J. Neuvonen, University of Helsinki, Helsinki, Finland

Federico Pea, University of Udine, Udine, Italy

Emilio Perucca, University of Pavia, Pavia, Italy

Johannes H. Proost, University of Groningen, Groningen, The Netherlands

MichaelS. Roberts, University of Queensland, Brisbane, QLD, Australia

Amparo Sánchez Navarro, Universidad de Salamanca, Salamanca, Spain

Catherine M. T. Sherwin, University of Utah, Salt Lake City, UT, USA

Susan Tett, University of Queensland, Brisbane, QLD, Australia

Michel Tod, Université Lyon, Paris, France

Daniel J. Touw, University Medical Center Groningen, Groningen, The Netherlands

Vijay V. Upreti, Amgen, Thousand Oaks, CA, USA

John N. van den Anker, Children’s National Health System, Washington, DC, USA

Teun van Gelder, Erasmus Medical Center, Rotterdam, The Netherlands


We do hope that you have found the articles published throughout the year in Clinical Pharmacokinetics to be interesting and informative. The editorial schedule for 2020 is well under way, and we are looking forward to bringing you many high-quality and authoritative articles over the coming year.


With best wishes,


Amitabh Prakash & Anton van Rensburg